Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Rita Maria Concetta Di Martino"'
Autor:
Francesca Seghetti, Rita Maria Concetta Di Martino, Elena Catanzaro, Alessandra Bisi, Silvia Gobbi, Angela Rampa, Barbara Canonico, Mariele Montanari, Dmitri V. Krysko, Stefano Papa, Carmela Fimognari, Federica Belluti
Publikováno v:
Molecules, Vol 25, Iss 13, p 3066 (2020)
The burden of neoplastic diseases is widely recognized as a severe cause of mortality. The clinical inadequacy of most anticancer therapeutics urgently prompted intense drug discovery efforts toward the identification of new chemical entities endowed
Externí odkaz:
https://doaj.org/article/9a79b61846734e9dbe01cea2a04d770b
Autor:
Angela Rampa, Andrea Tarozzi, Francesca Mancini, Letizia Pruccoli, Rita Maria Concetta Di Martino, Silvia Gobbi, Alessandra Bisi, Angela De Simone, Francesco Palomba, Nelsi Zaccheroni, Federica Belluti
Publikováno v:
Molecules, Vol 21, Iss 5, p 643 (2016)
Alzheimer’s disease (AD) has been defined as a multi-factorial disorder resulting from a complex array of networked cellular and molecular mechanisms. In particular, elevated levels of Aβ protein and its aggregation products in the presence of met
Externí odkaz:
https://doaj.org/article/0795ad3632c24f23b2925ddaf1ddfe62
Autor:
Irene Preet Bhela, Alice Ranza, Federica Carolina Balestrero, Marta Serafini, Silvio Aprile, Rita Maria Concetta Di Martino, Fabrizio Condorelli, Tracey Pirali
Publikováno v:
Journal of Medicinal Chemistry. 65:15282-15299
The use of small molecules to induce targeted protein degradation is increasingly growing in the drug discovery landscape, and protein degraders have progressed rapidly through the pipelines. Despite the advances made so far, their synthesis still re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9aef542bea5c4cb1c7b6e6bea55caa2
https://doi.org/10.1021/acs.jmedchem.2c01218
https://doi.org/10.1021/acs.jmedchem.2c01218
Publikováno v:
Expert Opinion on Therapeutic Patents. 32:605-627
Compelling evidence identified D3 dopamine receptor (D3R) as a suitable target for therapeutic intervention on CNS-associated disorders, cancer, and other conditions. Several efforts have been made toward developing potent and selective ligands for m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f455e2bcb7dee7c8d2e106b539252c92
https://doi.org/10.1080/13543776.2022.2049240
https://doi.org/10.1080/13543776.2022.2049240
Autor:
Federica Belluti, Andrea Tarozzi, Alessandra Bisi, Angela Rampa, Maria Paglione, Francesca Seghetti, Elia Di Schiavi, Loreto Martínez-González, Silvia Gobbi, Concepción Pérez, Rita Maria Concetta Di Martino, Ana Martínez, Letizia Pruccoli
Publikováno v:
ACS Chemical Neuroscience
ACS chemical neuroscience 11 (2020): 2728–2740. doi:10.1021/acschemneuro.0c00363
info:cnr-pdr/source/autori:Di Martino, Rita Maria Concetta; Pruccoli, Letizia; Bisi, Alessandra; Gobbi, Silvia; Rampa, Angela; Martinez, Ana; Pérez, Concepción; Martinez-Gonzalez, Loreto; Paglione, Maria; Di Schiavi, Elia; Seghetti, Francesca; Tarozzi, Andrea; Belluti, Federica/titolo:Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3? Inhibitor%2FNrf2 Inducer for the Treatment of Parkinson's Disease/doi:10.1021%2Facschemneuro.0c00363/rivista:ACS chemical neuroscience/anno:2020/pagina_da:2728/pagina_a:2740/intervallo_pagine:2728–2740/volume:11
Digital.CSIC. Repositorio Institucional del CSIC
instname
ACS chemical neuroscience 11 (2020): 2728–2740. doi:10.1021/acschemneuro.0c00363
info:cnr-pdr/source/autori:Di Martino, Rita Maria Concetta; Pruccoli, Letizia; Bisi, Alessandra; Gobbi, Silvia; Rampa, Angela; Martinez, Ana; Pérez, Concepción; Martinez-Gonzalez, Loreto; Paglione, Maria; Di Schiavi, Elia; Seghetti, Francesca; Tarozzi, Andrea; Belluti, Federica/titolo:Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3? Inhibitor%2FNrf2 Inducer for the Treatment of Parkinson's Disease/doi:10.1021%2Facschemneuro.0c00363/rivista:ACS chemical neuroscience/anno:2020/pagina_da:2728/pagina_a:2740/intervallo_pagine:2728–2740/volume:11
Digital.CSIC. Repositorio Institucional del CSIC
instname
26 p.-8 fig.-2 tab.-1 graph. abst.-+9 p. mat. supl.-10 fig.-2 tab.
Common copathogenic factors, including oxidative stress and neuroinflammation, are found to play a vital role in the development of neurodegenerative disorders, including Alzheim
Common copathogenic factors, including oxidative stress and neuroinflammation, are found to play a vital role in the development of neurodegenerative disorders, including Alzheim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525990dff3a74d6eb41933f0a0d8c1ff
https://doi.org/10.1021/acschemneuro.0c00363
https://doi.org/10.1021/acschemneuro.0c00363
Autor:
Ersilia De Lorenzi, Francesca Seghetti, Andrea Tarozzi, Letizia Pruccoli, Cecilia Contardi, Massimo Serra, Alessandra Bisi, Silvia Gobbi, Giulio Vistoli, Silvia Gervasoni, Carla Argentini, Giulia Ghirardo, Giulia Guarato, Genny Orso, Federica Belluti, Rita Maria Concetta Di Martino, Morena Zusso
Publikováno v:
European Journal of Medicinal Chemistry. 252:115297
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bdebe0b1ccc96c68ed0c736e5d3a3b
https://doi.org/10.1016/j.ejmech.2023.115297
https://doi.org/10.1016/j.ejmech.2023.115297
Autor:
Veronica Lunerti, Hongwu Li, Federica Benvenuti, Qianwei Shen, Ana Domi, Laura Soverchia, Rita Maria Concetta Di Martino, Giovanni Bottegoni, Carolina L. Haass-Koffler, Nazzareno Cannella
Publikováno v:
European journal of pharmacology. 928
Tobacco use disorder is a worldwide health problem for which available medications show limited efficacy. Nicotine is the psychoactive component of tobacco responsible for its addictive liability. Similar to other addictive drugs, nicotine enhances m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fbd78007cfdcc954cc8eb42508bbca
https://pubmed.ncbi.nlm.nih.gov/35690082
https://pubmed.ncbi.nlm.nih.gov/35690082
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9098, p 9098 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 9098, p 9098 (2021)
Protein kinases (PKs) have been recognized as central nervous system (CNS)-disease-relevant targets due to their master regulatory role in different signal transduction cascades in the neuroscience space. Among them, GSK-3β, FYN, and DYRK1A play a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02dae5812319f6ef1c2efe8f2bde410
http://europepmc.org/articles/PMC8396491
http://europepmc.org/articles/PMC8396491
Autor:
Dorothea Gobbo, Valentina Piretti, Rita Maria Concetta Di Martino, Shailesh Kumar Tripathi, Barbara Giabbai, Paola Storici, Nicola Demitri, Stefania Girotto, Sergio Decherchi, Andrea Cavalli
Publikováno v:
Journal of Chemical Theory and Computation. 15:4646-4659
It is widely accepted that drug-target association and dissociation rates directly affect drug efficacy and safety. To rationally optimize drug binding kinetics, one must know the atomic arrangement of the protein-ligand complex during the binding/un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037ab2decdb5de7ca0352c228c67b8fc
https://doi.org/10.1021/acs.jctc.9b00104
https://doi.org/10.1021/acs.jctc.9b00104