Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Rita M. Ramalho"'
Autor:
Sara R. Tanqueiro, Rita M. Ramalho, Tiago M. Rodrigues, Luísa V. Lopes, Ana M. Sebastião, Maria J. Diógenes
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Brain-derived neurotrophic factor (BDNF) plays important functions in cell survival and differentiation, neuronal outgrowth and plasticity. In Alzheimer’s disease (AD), BDNF signaling is known to be impaired, partially because amyloid β (Aβ) indu
Externí odkaz:
https://doaj.org/article/9825c12b389b45e5bdf16705ffc339de
Autor:
Joana D. Amaral, Ricardo J.S. Viana, Rita M. Ramalho, Clifford J. Steer, Cecília M.P. Rodrigues
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 9, Pp 1721-1734 (2009)
Bile acids are a group of molecular species of acidic steroids with peculiar physical-chemical and biological characteristics. At high concentrations they become toxic to mammalian cells, and their presence is pertinent in the pathogenesis of several
Externí odkaz:
https://doaj.org/article/74b78e9f01d243969354f043629798fe
Autor:
Ana Cristina Guerra Souza, Cecília M. P. Rodrigues, Rita M. Ramalho, Simone Pinton, Cristina W. Nogueira, Marcel Henrique Marcondes Sari
Publikováno v:
Behavioural Brain Research. 247:241-247
Behavioral evidence suggests that the organoselenium compound p , p ′-methoxyl-diphenyl diselenide [(MeOPhSe) 2 ] ameliorates memory and learning performance in rodents. Here, we investigated the molecular mechanism of (MeOPhSe) 2 neuroprotection i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::984b054e7ed8eaed0b1ab528f8037dd7
https://doi.org/10.1016/j.bbr.2013.03.034
https://doi.org/10.1016/j.bbr.2013.03.034
Autor:
Joana D. Amaral, Raquel B. Dias, Adrian C. Lo, Rita M. Ramalho, Ana Nunes, Rudi D'Hooge, Ana M. Sebastião, Cecília M. P. Rodrigues
Publikováno v:
Neurobiology of Aging
Synapses are considered the earliest site of Alzheimer's disease (AD) pathology, where synapse density is reduced, and synaptic loss is highly correlated with cognitive impairment. Tauroursodeoxycholic acid (TUDCA) has been shown to be neuroprotectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6400ff1c66de890e6836234f450cbd7e
https://doi.org/10.1016/j.neurobiolaging.2012.04.018
https://doi.org/10.1016/j.neurobiolaging.2012.04.018
Publikováno v:
Phytotherapy Research. 26:692-696
Seven lignans, previously isolated from Pycnanthus angolensis or obtained by derivatization, namely the dibenzylbutane-type lignans threo-4,4’-dihydroxy-3-methoxylignan (1), 4’-hydroxy-3,3’,4-trimethoxylignan (2), (−)-dihydroguaiaretic acid (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e602632b60dc9c1d6b1d3d0e3ffd256
https://doi.org/10.1002/ptr.3629
https://doi.org/10.1002/ptr.3629
Autor:
Rita M. Ramalho, Cecília M. P. Rodrigues, Cátia Ramalhete, X Luo, Maria-José U. Ferreira, Tayyab A. Mansoor
Publikováno v:
Phytotherapy Research. 25:1819-1824
Nine flavonoids isolated from the ethyl acetate extract of Pycnanthus angolensis were assayed for their potential apoptosis induction activities in human hepatoma HuH-7 cells. These flavonoids include eight isoflavones, namely irilone (1), tectorigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58858f07e802c68784a2f7c8efb1c3c2
https://doi.org/10.1002/ptr.3498
https://doi.org/10.1002/ptr.3498
Publikováno v:
CNS & Neurological Disorders - Drug Targets. 9:679-692
Neurodegenerative diseases trigger neuronal cell death by a variety of endogenous suicide pathways. Although cell death may occur through highly heterogeneous processes, specific cell organelles and stress sensors have shown promise as potential ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a90bc0f45dcfd939b463439f81b37ec
https://doi.org/10.2174/187152710793237511
https://doi.org/10.2174/187152710793237511
Publikováno v:
Journal of Alzheimer's Disease. 22:557-568
Amyloid-β (Aβ) peptide- induced neurotoxicity is typically associated with apoptosis. In previous studies, we have shown that tauroursodeoxycholic acid (TUDCA), an endogenous anti-apoptotic bile acid, modulates Aβ-induced apoptosis. Here, we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6060960887d631b2385808c0fb4142
https://doi.org/10.3233/jad-2010-100909
https://doi.org/10.3233/jad-2010-100909
Autor:
Cecília M. P. Rodrigues, Joana D. Amaral, Clifford J. Steer, Ricardo J.S. Viana, Rita M. Ramalho
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 9, Pp 1721-1734 (2009)
Bile acids are a group of molecular species of acidic steroids with peculiar physical-chemical and biological characteristics. At high concentrations they become toxic to mammalian cells, and their presence is pertinent in the pathogenesis of several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da6e33851a5a9c8ec07ae81594a97ad
http://www.sciencedirect.com/science/article/pii/S0022227520307252
http://www.sciencedirect.com/science/article/pii/S0022227520307252
Autor:
Cecília M. P. Rodrigues, Rui E. Castro, Rita M. Ramalho, Ricardo J.S. Viana, Walter C. Low, Clifford J. Steer
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The rTg4510 mouse is a tauopathy model, characterized by massive neurodegeneration in Alzheimer's disease (AD)-relevant cortical and limbic structures, deficits in spatial reference memory, and progression of neurofibrillary tangles (NFT). In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb78809d39b067e16bb94f74dd166ea6
https://doi.org/10.2119/2007-00133.ramalho
https://doi.org/10.2119/2007-00133.ramalho