Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Rita M. Cowell"'
Autor:
Nolwazi Z. Gcwensa, Dreson L. Russell, Khaliah Y. Long, Charlotte F. Brzozowski, Xinran Liu, Karen L. Gamble, Rita M. Cowell, Laura A. Volpicelli-Daley
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106595- (2024)
Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) are characterized by neuronal α-synuclein (α-syn) inclusions termed Lewy Pathology, which are abundant in the amygdala. The basolateral amygdala (BLA), in particular, receives projections
Externí odkaz:
https://doaj.org/article/090e4f4033cc4d278eafd11471bee7dd
Autor:
Skylar E. Davis, Anna K. Cook, Justin A. Hall, Yuliya Voskobiynyk, Nancy V. Carullo, Nicholas R. Boyle, Ahmad R. Hakim, Kristian M. Anderson, Kierra P. Hobdy, Derian A. Pugh, Charles F. Murchison, Laura J. McMeekin, Micah Simmons, Katherine A. Margolies, Rita M. Cowell, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Loss of function progranulin (GRN) mutations are a major autosomal dominant cause of frontotemporal dementia (FTD). Patients with FTD due to GRN mutations (FTD-GRN) develop frontotemporal lobar degeneration with TDP-43 pathology type A (FTLD
Externí odkaz:
https://doaj.org/article/cb7d9e8149f4472c81b6d7612826356c
Autor:
Allison R. Fusilier, Jennifer A. Davis, Jodi R. Paul, Stefani D. Yates, Laura J. McMeekin, Lacy K. Goode, Mugdha V. Mokashi, Natalie Remiszewski, Thomas van Groen, Rita M. Cowell, Lori L. McMahon, Erik D. Roberson, Karen L. Gamble
Publikováno v:
Neurobiology of Disease, Vol 158, Iss , Pp 105454- (2021)
Patients with Alzheimer's disease (AD) often have fragmentation of sleep/wake cycles and disrupted 24-h (circadian) activity. Despite this, little work has investigated the potential underlying day/night disruptions in cognition and neuronal physiolo
Externí odkaz:
https://doaj.org/article/170f4063c70843f29032fe341d423aa1
Autor:
Gelare Ghajar-Rahimi, Amie M. Traylor, Bini Mathew, James R. Bostwick, N Miranda Nebane, Anna A. Zmijewska, Stephanie K. Esman, Saakshi Thukral, Ling Zhai, Vijaya Sambandam, Rita M. Cowell, Mark J. Suto, James F. George, Corinne E. Augelli-Szafran, Anupam Agarwal
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1888 (2022)
Acute kidney injury (AKI) is a major public health concern with significant morbidity and mortality and no current treatments beyond supportive care and dialysis. Preclinical studies have suggested that heme-oxygenase-1 (HO-1), an enzyme that catalyz
Externí odkaz:
https://doaj.org/article/25f0f94d8f124a2fac06bb9aa63b0b1c
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Parkinson’s disease (PD) is a progressive neurodegenerative disease that impairs movement as well as causing multiple other symptoms such as autonomic dysfunction, rapid eye movement (REM) sleep behavior disorder, hyposmia, and cognitive changes. L
Externí odkaz:
https://doaj.org/article/d1a17e596a4543c3aded2a04905f74fa
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 8 (2021)
Oxidative stress has been implicated in the etiology and pathobiology of various neurodegenerative diseases. At baseline, the cells of the nervous system have the capability to regulate the genes for antioxidant defenses by engaging nuclear factor er
Externí odkaz:
https://doaj.org/article/e2378f5c431b47ea8e8509a3741c9b2c
Autor:
Jodi R. Paul, Daniel DeWoskin, Laura J. McMeekin, Rita M. Cowell, Daniel B. Forger, Karen L. Gamble
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
It is not clear how circadian biochemical cascades are encoded into neural electrical signals. Here, using a combination of electrophysiology and modelling approaches in mice, the authors show activation of glycogen synthase kinase 3 modulates neural
Externí odkaz:
https://doaj.org/article/55cf1eed826d46158f2e65325000bb43
Publikováno v:
Cells, Vol 10, Iss 2, p 352 (2021)
Substantial evidence indicates that mitochondrial impairment contributes to neuronal dysfunction and vulnerability in disease states, leading investigators to propose that the enhancement of mitochondrial function should be considered a strategy for
Externí odkaz:
https://doaj.org/article/62ee2bf063294916b1c1d226364c1659
Autor:
Mahendra Singh, Kiran Sapkota, Kenji Sakimura, Masanobu Kano, Rita M Cowell, Linda Overstreet-Wadiche, John J Hablitz, Kazu Nakazawa
Publikováno v:
Neuroscience. 513:38-53
Autor:
Andrew J. Treveylan, Rita M. Cowell, Claudia Racca, Robert Ryley Parrish, Connie Anne Mackenzie-Gray Scott, Darren Walsh
Publikováno v:
Journal of Neurophysiology
The transcriptional coactivator, PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1α), plays a key role in coordinating energy requirement within cells. Its importance is reflected in the growing number of psychiatric and neurologi