Výsledky vyhledávání - "Rita Holdhus"

Akademický článek

Patients with schizophrenia and bipolar disorder display a similar global gene expression signature in whole blood that reflects elevated proportion of immature neutrophil cells with association to lipid changes

Autor: Anja Torsvik, Hans-Richard Brattbakk, Andrea Trentani, Rita Holdhus, Christine Stansberg, Christoffer A. Bartz-Johannessen, Timothy Hughes, Nils Eiel Steen, Ingrid Melle, Srdjan Djurovic, Ole A. Andreassen, Vidar M. Steen

Publikováno v: Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Schizophrenia (SCZ) and bipolar disorder (BD) share clinical characteristics, genetic susceptibility, and immune alterations. We aimed to identify differential transcriptional patterns in peripheral blood cells of patients with SCZ or BD ver

Externí odkaz: https://doaj.org/article/16737f27f5464d82b06911d589a4ae5c

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Akademický článek

Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1.

Autor: Vidar M Steen, Chirag Nepal, Kari M Ersland, Rita Holdhus, Marianne Nævdal, Siri M Ratvik, Silje Skrede, Bjarte Håvik

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79501 (2013)

Recent meta-analyses of schizophrenia genome-wide association studies (GWASs) have identified the CUB and SUSHI multiple domains 1 (CSMD1) gene as a statistically strong risk factor. CSMD1 is a complement control-related protein suggested to inhibit

Externí odkaz: https://doaj.org/article/d88e54d129544816924ae23e36500782

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Akademický článek

Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern

Autor: Heidi M. Namløs, Stine H. Kresse, Christoph R. Müller, Jørn Henriksen, Rita Holdhus, Gunnar Sæter, Øyvind S. Bruland, Bodil Bjerkehagen, Vidar M. Steen, Ola Myklebost

Publikováno v: Sarcoma, Vol 2012 (2012)

Global gene expression analysis was performed on a panel of 23 osteosarcoma samples of primary and metastatic origin using the Applied Biosystems Gene Expression Array System. When comparing the primary tumours with the metastases, we found a signifi

Externí odkaz: https://doaj.org/article/ab446f5665624c7e86e4cc87e8b699aa

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Akademický článek

Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss.

Autor: Simon N Dankel, Dag J Fadnes, Anne-Kristin Stavrum, Christine Stansberg, Rita Holdhus, Tuyen Hoang, Vivian L Veum, Bjørn Jostein Christensen, Villy Våge, Jørn V Sagen, Vidar M Steen, Gunnar Mellgren

Publikováno v: PLoS ONE, Vol 5, Iss 6, p e11033 (2010)

BACKGROUND: In obesity, impaired adipose tissue function may promote secondary disease through ectopic lipid accumulation and excess release of adipokines, resulting in systemic low-grade inflammation, insulin resistance and organ dysfunction. Howeve

Externí odkaz: https://doaj.org/article/4a4c746cb5c946098f091dabaa15f08f

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Gene expression response in peripheral blood cells of petroleum workers exposed to sub-ppm benzene levels

Autor: Bjørn Tore Gjertsen, Nancy B. Hopf, Rita Holdhus, Anne-Kristin Stavrum, Katarina Mariann Jørgensen, Ellen Færgestad Mosleth, Kristian Hovde Liland, Jorunn Kirkeleit

Publikováno v: International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, Vol 15, Iss 11, p 2385 (2018)
Volume 15
Issue 11
International Journal of Environmental Research and Public Health, vol. 15, no. 11, pp. 2385

Altered gene expression in pathways relevant to leukaemogenesis, as well as reduced levels of circulating lymphocytes, have been reported in workers that were exposed to benzene concentrations below 1 ppm. In this study, we analysed whole blood globa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73abfd369f6c357c36fe4ab1b8d9fc18
https://hdl.handle.net/11250/2584406

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RareVariantVis: new tool for visualization of causative variants in rare monogenic disorders using whole genome sequencing data

Autor: Paweł Sztromwasser, Alexander Hoischen, Tomasz Stokowy, Christian Gilissen, Gunnar Houge, Torunn Fiskerstrand, Rita Holdhus, Inge Jonassen, Kjell Petersen, Kornel Labun, Vidar M. Steen, Mateusz Garbulowski

Publikováno v: Bioinformatics, 32, 3018-20
Bioinformatics, 32, 19, pp. 3018-20
Europe PubMed Central

Motivation: The search for causative genetic variants in rare diseases of presumed monogenic inheritance has been boosted by the implementation of whole exome (WES) and whole genome (WGS) sequencing. In many cases, WGS seems to be superior to WES, bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397df843c80612f5c158e2d30a3ad095
http://hdl.handle.net/2066/168090

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Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern

Autor: Gunnar Sæter, Ola Myklebost, Jørn Henriksen, Vidar M. Steen, Stine H. Kresse, Øyvind S. Bruland, Rita Holdhus, Bodil Bjerkehagen, Heidi M. Namløs, Christoph R. Müller

Publikováno v: Sarcoma, Vol 2012 (2012)
Sarcoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd55b658fdffb74f3deb3bf02f6bfb30
https://doi.org/10.1155/2012/639038

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Syndromic X-linked intellectual disability segregating with a missense variant in RLIM

Autor: Torunn Fiskerstrand, Rita Holdhus, Han G. Brunner, Elin Tønne, Asbjørg Stray-Pedersen, Kjell Petersen, Alexander Hoischen, Christian Gilissen, Christine Stansberg, Vidar M. Steen, Trine Prescott

Publikováno v: European Journal of Human Genetics, 23, 12, pp. 1652-6
European Journal of Human Genetics, 23, 1652-6

Contains fulltext : 152770.pdf (Publisher’s version ) (Open Access) We describe a three-generation Norwegian family with a novel X-linked intellectual disability (XLID) syndrome characterized by subtle facial dysmorphism, autism and severe feeding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5294d0752f08371780618e1ab9d0027f
https://hdl.handle.net/2066/152770

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Publikováno v: Journal of Clinical Investigation, 125, 8, pp. 3051-62
Journal of Clinical Investigation, 125, 3051-62
Journal of Clinical Investigation, 125(8), 3051. The American Society for Clinical Investigation

Contains fulltext : 154618.pdf (Publisher’s version ) (Open Access) Here we report inherited dysregulation of protein phosphatase activity as a cause of intellectual disability (ID). De novo missense mutations in 2 subunits of serine/threonine (Ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd9601c02f047e2045b4159973a49f3
https://dspace.library.uu.nl/handle/1874/331679

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Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect

Autor: Håkon Reikvam, Laury Poulain, Elisabeth Ersvær, Øystein Bruserud, Kimberley Joanne Hatfield, Rita Holdhus, Silje Skrede, Jerome Tamburini

Publikováno v: British journal of haematology. 164(2)

Acute myeloid leukaemia (AML) is a heterogeneous malignancy. Intracellular signalling through the phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) pathway is important for regulation of cellular growth and metabolism, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdbf126ccb3ce4bae38c8bc76f1ef42
https://pubmed.ncbi.nlm.nih.gov/24383842

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