Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Rita H. Najor"'
Autor:
Wenjing Liang, Shakti Sagar, Rishith Ravindran, Rita H. Najor, Justin M. Quiles, Liguo Chi, Rachel Y. Diao, Benjamin P. Woodall, Leonardo J. Leon, Erika Zumaya, Jason Duran, David M. Cauvi, Antonio De Maio, Eric D. Adler, Åsa B. Gustafsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Mitochondrial quality control is critical for cardiac homeostasis as these organelles are responsible for generating most of the energy needed to sustain contraction. Dysfunctional mitochondria are normally degraded via intracellular degrada
Externí odkaz:
https://doaj.org/article/02588d67bd4f4beeb14563fa5e5e84d7
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102914- (2024)
Summary: Extracellular vesicles (EVs) are secreted by cells under various conditions and can contribute to the disease progression in tissues. Here, we present a protocol to separate small and large EVs from mouse hearts and cardiac tissues collected
Externí odkaz:
https://doaj.org/article/3a1cfeef5a8d4a9782a22f607f25c009
Publikováno v:
Cells, Vol 11, Iss 9, p 1469 (2022)
Myeloid cell leukemia-1 (Mcl-1) is a unique antiapoptotic Bcl-2 member that is critical for mitochondrial homeostasis. Recent studies have demonstrated that Mcl-1′s functions extend beyond its traditional role in preventing apoptotic cell death. Sp
Externí odkaz:
https://doaj.org/article/7374be493b0a4ebab23b2257751eb359
Autor:
Babette C. Hammerling, Rita H. Najor, Melissa Q. Cortez, Sarah E. Shires, Leonardo J. Leon, Eileen R. Gonzalez, Daniela Boassa, Sébastien Phan, Andrea Thor, Rebecca E. Jimenez, Hong Li, Richard N. Kitsis, Gerald W. Dorn II, Junichi Sadoshima, Mark H. Ellisman, Åsa B. Gustafsson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Damaged mitochondria are normally cleared through canonical and alternative autophagy pathways. Here, the authors report that mitochondria can be cleared through an autophagy-independent endosomal-lysosomal pathway that depends on Parkin-dependent se
Externí odkaz:
https://doaj.org/article/b90a7538f1694e4281da0c789cbd7c2c
Autor:
Justin M. Quiles, Rita H. Najor, Eileen Gonzalez, Monica Jeung, Wenjing Liang, Sarah M. Burbach, Erika A. Zumaya, Rachel Y. Diao, Mark A. Lampert, Åsa B. Gustafsson
Publikováno v:
Sci Signal
The degradation of macromolecules and organelles by the process of autophagy is critical for cellular homeostasis and is often compromised during aging and disease. Beclin1 and Beclin2 are implicated in autophagy induction, and these homologs share a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e91435c6d73fc72d422a240775993d0
https://doi.org/10.1126/scisignal.abo4457
https://doi.org/10.1126/scisignal.abo4457
Publikováno v:
Circulation Research. 131
Alpha-B-crystallin (CryAB) is an abundant molecular chaperone comprising nearly 5% of total cardiac mass. While predominately cytosolic, some studies note mitochondrial translocation of CryAB during stress. The autosomal dominant R120G mutation leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd76d7f78069fe8de7f8720c28bac44e
https://doi.org/10.1161/res.131.suppl_1.p3033
https://doi.org/10.1161/res.131.suppl_1.p3033
Autor:
Leonardo J. Leon, Amabel M. Orogo, Åsa B. Gustafsson, Alexandra G. Moyzis, Navraj S. Lally, Rita H. Najor, Wenjing Liang
Publikováno v:
J Mol Cell Cardiol
Myeloid cell leukemia-1 (Mcl-1) is a structurally and functionally unique anti-apoptotic Bcl-2 protein. While elevated levels of Mcl-1 contribute to tumor cell survival and drug resistance, loss of Mcl-1 in cardiac myocytes leads to rapid mitochondri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efedd271549544832c52ca19373578ce
https://doi.org/10.1016/j.yjmcc.2020.07.009
https://doi.org/10.1016/j.yjmcc.2020.07.009
Autor:
Dieter A Kubli, Melissa Q Cortez, Alexandra G Moyzis, Rita H Najor, Youngil Lee, Åsa B Gustafsson
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130707 (2015)
Myocyte function and survival relies on the maintenance of a healthy population of mitochondria. The PINK1/Parkin pathway plays an important role in clearing defective mitochondria via autophagy in cells. However, how the PINK1/Parkin pathway regulat
Externí odkaz:
https://doaj.org/article/e8fd34d625a2450dbccdefe2fe94ff7a
Autor:
Alexandra G. Moyzis, Åsa B. Gustafsson, Rita H. Najor, Mark A Lampert, Wenjing Liang, Rachel Y. Diao
Publikováno v:
Aging Cell
Advancing age is a major risk factor for developing heart disease, and the biological processes contributing to aging are currently under intense investigation. Autophagy is an important cellular quality control mechanism that is reduced in tissues w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c97a496eb92b3a42548bee90e0ee290
https://doi.org/10.1096/fasebj.2021.35.s1.02609
https://doi.org/10.1096/fasebj.2021.35.s1.02609
Autor:
Mark A Lampert, Rita H. Najor, Adam Mark, Åsa B. Gustafsson, Sarah E. Shires, Leonardo J. Leon, Justin M. Quiles, Melissa Q. Cortez
Publikováno v:
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Parkin is an E3 ubiquitin ligase well-known for facilitating clearance of damaged mitochondria by ubiquitinating proteins on the outer mitochondrial membrane. However, knowledge of Parkin’s functions beyond mitophagy is still limited. Here, we demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d78528eb4fc4226a7c8014d0fd9d84
https://escholarship.org/uc/item/4j968324
https://escholarship.org/uc/item/4j968324
