Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Rita Grantner"'
Autor:
Michael R. Collins, Robert Steven Kania, Connie Fan, Sutton Scott Channing, Dominique Verhelle, Kephart Susan Elizabeth, Martin James Wythes, Shuiwang Wang, Karen A. Maegley, Lisa Nguyen, Daniel Tyler Richter, A.E. Stewart, Pei-Pei Kung, Buwen Huang, Shikhar Sharma, Shinji Yamazaki, Ya-Li Deng, Rita Grantner, Patrick Bingham, Robert Arnold Kumpf, Penney Khamphavong, Jinjiang Zhu, Dac M. Dinh, Manfred Kraus, Wei Liu, Sean Uryu, Jillian E. Spangler, Wenyue Hu, Hui Wang, Robert A. Rollins, Cody Krivacic, Zehnder Luke Raymond, Neal W. Sach, Alexei Brooun, John Sherrill, Shijian Ren, Martin A. Edwards, Huichun Zhu, Ketan S. Gajiwala, Shuibo Xin, Hovhannes J. Gukasyan
Publikováno v:
Journal of Medicinal Chemistry. 61:650-665
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f30f1b1d2d6acfd5a3cfe913d0c1179d
https://doi.org/10.1021/acs.jmedchem.7b01375
https://doi.org/10.1021/acs.jmedchem.7b01375
Autor:
Xiaoli Wang, Stephan Grant, Rita Grantner, Ben Bolaños, Casey L. Quinlan, Stephen E. Kaiser, Shannon Karlicek-Bryant, Stephen Jenkinson, Valeria R Fantin, Peter A. Wells, Jun Li Feng, Stephen Dann, Al E. Stewart, Nowlin Dawn Marie, Kevin Daniel Freeman-Cook
Publikováno v:
Nature Chemical Biology. 13:785-792
S-Adenosyl-L-methionine (SAM) is an enzyme cofactor used in methyl transfer reactions and polyamine biosynthesis. The biosynthesis of SAM from ATP and L-methionine is performed by the methionine adenosyltransferase enzyme family (Mat; EC 2.5.1.6). Hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff868d879f490f612b5686abb0517c0
https://doi.org/10.1038/nchembio.2384
https://doi.org/10.1038/nchembio.2384
Autor:
Pei-Pei, Kung, Patrick, Bingham, Alexei, Brooun, Michael, Collins, Ya-Li, Deng, Dac, Dinh, Connie, Fan, Ketan S, Gajiwala, Rita, Grantner, Hovhannes J, Gukasyan, Wenyue, Hu, Buwen, Huang, Robert, Kania, Susan E, Kephart, Cody, Krivacic, Robert A, Kumpf, Penney, Khamphavong, Manfred, Kraus, Wei, Liu, Karen A, Maegley, Lisa, Nguyen, Shijian, Ren, Dan, Richter, Robert A, Rollins, Neal, Sach, Shikhar, Sharma, John, Sherrill, Jillian, Spangler, Albert E, Stewart, Scott, Sutton, Sean, Uryu, Dominique, Verhelle, Hui, Wang, Shuiwang, Wang, Martin, Wythes, Shuibo, Xin, Shinji, Yamazaki, Huichun, Zhu, JinJiang, Zhu, Luke, Zehnder, Martin, Edwards
Publikováno v:
Journal of medicinal chemistry. 61(3)
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47b5a14cd255ea7adedb733daa3e1969
https://pubmed.ncbi.nlm.nih.gov/29211475
https://pubmed.ncbi.nlm.nih.gov/29211475
Autor:
Michael A. Grassi, Evgeny V. Berdyshev, Ravi Shah, Joseph Bogaard, Wenbo Mu, Dingcai Cao, Jerry J. White, Qing Chang, Rita Grantner, Sam Bettis, Siquan Chen
Degenerative loss of photoreceptors occurs in inherited and age-related retinal degenerative diseases. A chemical screen facilitates development of new testing routes for neuroprotection and mechanistic investigation. Herein, we conducted a mouse-der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b4c800acbd4fb0ea192552198b7ec7
https://europepmc.org/articles/PMC3961660/
https://europepmc.org/articles/PMC3961660/
