Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Rita Field"'
Autor:
Xichen Lin, Michael E. Muratore, Huijie Li, Ami S. Lakdawala, Jakob Busch-Petersen, Ruth R. Osborn, David D. Miller, Jeffrey K. Kerns, Rick P. C. Cousins, Ian Robert Baldwin, Paul Bamborough, John Yonchuk, Ann M. Bullion, Lin Guoliang, Jeffrey C. Boehm, Wei Fu, John A. Christopher, Edward F. Webb, Roderick S. Davis, William L. Rumsey, Rita Field, Jeremy John Payne, Hong Nie
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1164-1169
[Image: see text] IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the optimization of a series of 3,5-disubstituted-indole-7-carboxamides for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782cb7b7a63c400db0be5e5461917822
https://doi.org/10.1021/acsmedchemlett.8b00291
https://doi.org/10.1021/acsmedchemlett.8b00291
Autor:
Peter R. Butchers, Claire E. Smith, Iain M. McLay, Rosemary Sasse, Keith Biggadike, Peter J. Mutch, Panayiotis A. Procopiou, Stephen A. Richards, Richard Conroy, Diane M. Coe, Edney Dean David, Stephen Barry Guntrip, Alison J. Ford, Rita Field, Brian Edgar Looker, Nicola Bevan, Michael John Monteith, Victoria J. Barrett, Valerie S. Morrison
Publikováno v:
Journal of Medicinal Chemistry. 52:2280-2288
A series of saligenin alkoxyalkylphenylsulfonamide beta(2) adrenoceptor agonists were prepared by reacting a protected saligenin oxazolidinone with alkynyloxyalkyl bromides, followed by Sonogashira reaction, hydrogenation, and deprotection. The meta-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499a1a13ce7c286c1210e3f46005da6b
https://doi.org/10.1021/jm801016j
https://doi.org/10.1021/jm801016j