Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Rita Distinto"'
Autor:
Nadine Jagerovic, Ilaria Manca, Ruth A. Ross, Paula Morales, Paolo Lazzari, Marilena Pira, Gérard Aimé Pinna, Gemma L. Baillie, Matteo Zanda, Gabriele Murineddu, Matteo Falzoi, Monica Sani, Rita Distinto
Publikováno v:
European journal of medicinal chemistry 121 (2016): 194–208. doi:10.1016/j.ejmech.2016.05.011
info:cnr-pdr/source/autori:Lazzari P.; Distinto R.; Manca I.; Baillie G.; Murineddu G.; Pira M.; Falzoi M.; Sani M.; Morales P.; Ross R.; Zanda M.; Jagerovic N.; Pinna G.A./titolo:A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-Tetrahydrobenzo[6,7]cyclohepta[1,2-c ]pyrazole-3-carboxamide and analogue derivatives/doi:10.1016%2Fj.ejmech.2016.05.011/rivista:European journal of medicinal chemistry/anno:2016/pagina_da:194/pagina_a:208/intervallo_pagine:194–208/volume:121
info:cnr-pdr/source/autori:Lazzari P.; Distinto R.; Manca I.; Baillie G.; Murineddu G.; Pira M.; Falzoi M.; Sani M.; Morales P.; Ross R.; Zanda M.; Jagerovic N.; Pinna G.A./titolo:A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-Tetrahydrobenzo[6,7]cyclohepta[1,2-c ]pyrazole-3-carboxamide and analogue derivatives/doi:10.1016%2Fj.ejmech.2016.05.011/rivista:European journal of medicinal chemistry/anno:2016/pagina_da:194/pagina_a:208/intervallo_pagine:194–208/volume:121
8-Chloro-1-(2?,4?-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide 9a was discovered as potent and selective CB1 antagonist by part of our group few years ago. In particular it was reported to have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea8e6fe135fe0e3f2913f3cd98abc8d
https://doi.org/10.1016/j.ejmech.2016.05.011
https://doi.org/10.1016/j.ejmech.2016.05.011
Autor:
Paolo Lazzari a, b, c, Rita Distinto a, Ilaria Manca a, Gemma Baillie b, d, Gabriele Murineddu e, Marilena Pira a, Matteo Falzoi f, Monica Sani c, g, Paula Morales h, Ruth Ross b, Matteo Zanda b, Nadine Jagerovic h, Gerard Aime Pinna e
Publikováno v:
European journal of medicinal chemistry (2015): 194–208. doi:10.1016/j.ejmech.2016.05.011
info:cnr-pdr/source/autori:Paolo Lazzari a, b, c, *, Rita Distinto a, b, Ilaria Manca a, b, Gemma Baillie b, d, Gabriele Murineddu e, Marilena Pira a, b, Matteo Falzoi f, Monica Sani c, g, Paula Morales h, Ruth Ross b, d, Matteo Zanda b, g, Nadine Jagerovic h, Gerard Aime Pinna e/titolo:A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(20,40-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives/doi:10.1016%2Fj.ejmech.2016.05.011/rivista:European journal of medicinal chemistry/anno:2015/pagina_da:194/pagina_a:208/intervallo_pagine:194–208/volume
info:cnr-pdr/source/autori:Paolo Lazzari a, b, c, *, Rita Distinto a, b, Ilaria Manca a, b, Gemma Baillie b, d, Gabriele Murineddu e, Marilena Pira a, b, Matteo Falzoi f, Monica Sani c, g, Paula Morales h, Ruth Ross b, d, Matteo Zanda b, g, Nadine Jagerovic h, Gerard Aime Pinna e/titolo:A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(20,40-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives/doi:10.1016%2Fj.ejmech.2016.05.011/rivista:European journal of medicinal chemistry/anno:2015/pagina_da:194/pagina_a:208/intervallo_pagine:194–208/volume
8-Chloro-1-(20,40-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole- 3-carboxamide 9a was discovered as potent and selective CB1 antagonist by part of our group few years ago. In particular it was reported to have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=cnr_________::4137be4fd7ba68f569127cc059368d6c
Autor:
Matteo Zanda, Serena Montanari, Paolo Lazzari, Roger G. Pertwee, Chiara Zanato, Maria Grazia Cascio, Rita Distinto
Publikováno v:
Journal of fluorine chemistry
(2014). doi:10.1016/j.jfluchem.2014.07.010
info:cnr-pdr/source/autori:Distinto R.; Zanato C.; Montanari S.; Cascio M.G.; Lazzari P.; Pertwee R.; Zanda M./titolo:Pyrazoles with a "click" 4-[N-(4-fluorobutyl)-1,2,3-triazole] substituent in position 3 are nanomolar CB1 receptor ligands/doi:10.1016%2Fj.jfluchem.2014.07.010/rivista:Journal of fluorine chemistry (Print)/anno:2014/pagina_da:/pagina_a:/intervallo_pagine:/volume
(2014). doi:10.1016/j.jfluchem.2014.07.010
info:cnr-pdr/source/autori:Distinto R.; Zanato C.; Montanari S.; Cascio M.G.; Lazzari P.; Pertwee R.; Zanda M./titolo:Pyrazoles with a "click" 4-[N-(4-fluorobutyl)-1,2,3-triazole] substituent in position 3 are nanomolar CB1 receptor ligands/doi:10.1016%2Fj.jfluchem.2014.07.010/rivista:Journal of fluorine chemistry (Print)/anno:2014/pagina_da:/pagina_a:/intervallo_pagine:/volume
Replacement of the 3-carbonylaminopiperidine substitutent with a “click” 4-[ N -(4-fluorobutyl)-(1,2,3-triazolyl)] group in Rimonabant-type pyrazoles produced a novel class of nanomolar CB 1 receptor ligands. Molecule 1d is the most promising lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76562415674be81e328696eec07e6cd3
http://hdl.handle.net/11585/397584
http://hdl.handle.net/11585/397584