Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Rita Carini"'
Autor:
Nausicaa Clemente, Simona Baroni, Simone Fiorilla, Francesco Tasso, Simone Reano, Chiara Borsotti, Maria Rosaria Ruggiero, Elisa Alchera, Marco Corrazzari, Gillian Walker, Antonia Follenzi, Simonetta Geninatti Crich, Rita Carini
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Pharmacological treatments for advanced hepatocellular carcinoma (HCC) have a partial efficacy. Augmented Na+ content and water retention are observed in human cancers and offer unexplored targets for anticancer therapies. Na+ levels are eva
Externí odkaz:
https://doaj.org/article/7b9e3af363b549a185401d7669fa6d39
Autor:
Elisa Alchera, Bangalore R. Chandrashekar, Nausicaa Clemente, Ester Borroni, Renzo Boldorini, Rita Carini
Publikováno v:
Cells, Vol 10, Iss 11, p 3171 (2021)
Hepatic ischemia/reperfusion injury (IRI) is aggravated by steatosis and is a main risk factor in fatty liver transplantation. Adenosine receptors (ARs) are emerging as therapeutic targets in liver diseases. By using cellular and in vivo systems of h
Externí odkaz:
https://doaj.org/article/32c3e3d1bb7b4b1e8ee659da66e56c9b
Autor:
Chiara Imarisio, Antonia Follenzi, Rita Carini, Elisa Alchera, Emanuele Albano, Maria Prat, Caterina Dal Ponte
Publikováno v:
Liver Transplantation. 17:474-482
Postconditioning is a procedure based on the induction of intracellular protective reactions immediately after the onset of reperfusion. Because of the growing need to prevent ischemia/reperfusion (I/R) injury during liver surgery and transplantation
Autor:
Gianluca Baldanzi, Maria Grazia De Cesaris, Elisa Alchera, Rita Carini, Roberta Splendore, Daniela Piranda, Emanuele Albano
Publikováno v:
Journal of Hepatology. 45:236-245
Background/Aims ATP stimulation of purinergic P2 receptors (P2YR and P2XR) regulates several hepatic functions. Here we report the involvement of ATP-mediated signals in enhancing hepatocyte tolerance to lethal stress. Methods The protection given by
Autor:
Roberta Castino, Maria Grazia De Cesaris, Elisa Alchera, Emanuele Albano, Ciro Isidoro, Nicol F. Trincheri, Roberta Splendore, Rita Carini
Publikováno v:
Free Radical Biology and Medicine. 40:1738-1748
We investigated the signal mediators and the cellular events involved in the nitric oxide (NO)-induced hepatocyte resistance to oxygen deprivation in isolated hepatocytes treated with the NO donor (Z)-1-(N-methyl-N-[6-(N-methylammoniohexyl)amino])dia
Autor:
Nicoletta Filigheddu, Gianluca Baldanzi, Andrea Graziani, Elisa Alchera, Cinzia Domenicotti, Emanuele Albano, Maria Adelaide Pronzato, Maria Grazia De Cesaris, Roberta Splendore, Mariapaola Nitti, Rita Carini
Publikováno v:
Università degli Studi del Piemonte Orientale-IRIS
BACKGROUND & AIMS: Ischemic preconditioning has been proved effective in reducing ischemia/reperfusion injury during liver surgery. However, the mechanisms involved are still poorly understood. Here, we have investigated the role of phosphatidylinosi
Autor:
Maria Grazia De Cesaris, Rita Carini, Roberta Splendore, Roberta Castino, Marina Démoz, Emanuele Albano, Ciro Isidoro
Publikováno v:
Journal of Cell Science. 117:1065-1077
A short period of hypoxia reduces the cytotoxicity produced by a subsequent prolonged hypoxia in isolated hepatocytes. This phenomenon, termed hypoxic preconditioning, is mediated by the activation of adenosine A2A-receptor and is associated with the
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1502:508-514
Centrilobular hypoxia has been suggested to contribute to hepatic damage caused by alcohol intoxication. However, the mechanisms involved are still poorly understood. We have investigated whether alterations of Na + homeostasis might account for etha
Autor:
Rita Carini, Roberta Splendore, Giorgio Bellomo, Marco Bagnati, Emanuele Albano, Maria Grazia De Cesaris
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1500:297-305
Reperfusion injury represents an important cause of primary graft non-function during liver transplantation. However, the mechanism responsible for cellular damage during reoxygenation has not yet been completely understood. We have investigated whet
Publikováno v:
Transplantation. 68:294-297
Background. The mechanisms responsible for liver damage during cold storage are still not completely understood. We have investigated the role played by alterations of Na + homeostasis in cell injury during cold hypoxia. Methods. The changes in Na +