Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Rita C.R. Perlingeiro"'
Autor:
Lisa S. Chow, Darko Bosnakovski, Douglas G. Mashek, Michael Kyba, Rita C.R. Perlingeiro, Alessandro Magli
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102496- (2021)
Satellite cells represent the main myogenic population accounting for skeletal muscle homeostasis and regeneration. While our knowledge of the signaling pathways controlling satellite cell regenerative capability is increasing, the underlying epigene
Externí odkaz:
https://doaj.org/article/ba675eb0761e46d791ae737bbfb58945
Autor:
Neha R. Dhoke, Hyunkee Kim, Sridhar Selvaraj, Karim Azzag, Haowen Zhou, Nelio A.J. Oliveira, Sudheer Tungtur, Carolina Ortiz-Cordero, James Kiley, Qi Long Lu, Anne G. Bang, Rita C.R. Perlingeiro
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109360- (2021)
Summary: Mutations in the fukutin-related protein (FKRP) gene result in a broad spectrum of muscular dystrophy (MD) phenotypes, including the severe Walker-Warburg syndrome (WWS). Here, we develop a gene-editing approach that replaces the entire muta
Externí odkaz:
https://doaj.org/article/6c28b824295349c796db8b9112b5789f
Autor:
Ricardo Mondragon-Gonzalez, Karim Azzag, Sridhar Selvaraj, Ami Yamamoto, Rita C.R. Perlingeiro
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 553-562 (2019)
Background: Stem cell transplantation represents a potential therapeutic option for muscular dystrophies (MD). However, to date, most reports have utilized mouse models for recessive types of MD. Here we performed studies to determine whether myotoni
Externí odkaz:
https://doaj.org/article/3d1ddf5f0da9456b9e9fc0621d7320a3
Publikováno v:
Stem Cell Research, Vol 23, Iss C, Pp 87-94 (2017)
Currently, the most efficient and promising approach for generating large numbers of engraftable human skeletal myogenic progenitors from pluripotent stem cells requires the conditional in vitro overexpression of PAX7 using lentiviral vectors. Becaus
Externí odkaz:
https://doaj.org/article/86cdec141f4947ef8fe545c22ed08808
Autor:
Jaemin Kim, Alessandro Magli, Sunny S.K. Chan, Vanessa K.P. Oliveira, Jianbo Wu, Radbod Darabi, Michael Kyba, Rita C.R. Perlingeiro
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 12-22 (2017)
Recent reports have documented the differentiation of human pluripotent stem cells toward the skeletal myogenic lineage using transgene- and cell purification-free approaches. Although these protocols generate myocytes, they have not demonstrated sca
Externí odkaz:
https://doaj.org/article/ed612bed99ae47dcac2b1087e212cf7a
Autor:
Alessandro Magli, Tania Incitti, James Kiley, Scott A. Swanson, Radbod Darabi, Fabrizio Rinaldi, Sridhar Selvaraj, Ami Yamamoto, Jakub Tolar, Ce Yuan, Ron Stewart, James A. Thomson, Rita C.R. Perlingeiro
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2867-2877 (2017)
Pluripotent stem (PS)-cell-derived cell types hold promise for treating degenerative diseases. However, PS cell differentiation is intrinsically heterogeneous; therefore, clinical translation requires the development of practical methods for isolatin
Externí odkaz:
https://doaj.org/article/70614948bf39434b9fc02261805bfe17
Autor:
Guadalupe Elizabeth Jimenez-Gutierrez, Ricardo Mondragon-Gonzalez, Luz Adriana Soto-Ponce, Wendy Lilián Gómez-Monsiváis, Ian García-Aguirre, Ruth Abigail Pacheco-Rivera, Rocío Suárez-Sánchez, Andrea Brancaccio, Jonathan Javier Magaña, Rita C.R. Perlingeiro, Bulmaro Cisneros
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 14, p 4961 (2020)
Nuclear β-dystroglycan (β-DG) is involved in the maintenance of nuclear architecture and function. Nonetheless, its relevance in defined nuclear processes remains to be determined. In this study we generated a C2C12 cell-based DG-null model using C
Externí odkaz:
https://doaj.org/article/936f63982913458c84f903ab607a4f24
Autor:
Abhijit Dandapat, Darko Bosnakovski, Lynn M. Hartweck, Robert W. Arpke, Kristen A. Baltgalvis, Derek Vang, June Baik, Radbod Darabi, Rita C.R. Perlingeiro, F. Kent Hamra, Kalpna Gupta, Dawn A. Lowe, Michael Kyba
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1484-1496 (2014)
Facioscapulohumeral muscular dystrophy (FSHD) is an enigmatic disease associated with epigenetic alterations in the subtelomeric heterochromatin of the D4Z4 macrosatellite repeat. Each repeat unit encodes DUX4, a gene that is normally silent in most
Externí odkaz:
https://doaj.org/article/20445cf0808e4af4a600615bb0b4246c
Autor:
Bhairab N. Singh, Dogacan Yucel, Bayardo I. Garay, Elena G. Tolkacheva, Michael Kyba, Rita C.R. Perlingeiro, Jop H. van Berlo, Brenda M. Ogle
Publikováno v:
Circulation Research. 132:519-540
During cardiac development and morphogenesis, cardiac progenitor cells differentiate into cardiomyocytes that expand in number and size to generate the fully formed heart. Much is known about the factors that regulate initial differentiation of cardi
Autor:
Sunny Sun Kin Chan, Lindsay N. Peifer, Michael Kyba, Karim Azzag, Sabrina N. Chu, Rita C.R. Perlingeiro, Ning Xie, Cassandra B. Schultz
Publikováno v:
Stem Cell Reports
Summary One major challenge in realizing cell-based therapy for treating muscle-wasting disorders is the difficulty in obtaining therapeutically meaningful amounts of engraftable cells. We have previously described a method to generate skeletal myoge