Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Rita Börzsei"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5945 (2024)
Histones are keys to many epigenetic events and their complexes have therapeutic and diagnostic importance. The determination of the structures of histone complexes is fundamental in the design of new drugs. Computational molecular docking is widely
Externí odkaz:
https://doaj.org/article/b87b4ba235fd48a984e3d8db639a1d1a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13831 (2023)
The structures of histone complexes are master keys to epigenetics. Linear histone peptide tails often bind to shallow pockets of reader proteins via weak interactions, rendering their structure determination challenging. In the present study, a new
Externí odkaz:
https://doaj.org/article/e452991f19f04b3da6363987129c7963
Autor:
Balázs Zoltán Zsidó, Bayartsetseg Bayarsaikhan, Rita Börzsei, Viktor Szél, Violetta Mohos, Csaba Hetényi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11784 (2023)
Water is a key actor of various processes of nature and, therefore, molecular engineering has to take the structural and energetic consequences of hydration into account. While the present review focuses on the target–ligand interactions in drug de
Externí odkaz:
https://doaj.org/article/5c64f5bb8f024b40bdb24235ecb92e15
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11316 (2022)
The protein arginine methyltransferase 5 (PRMT5) enzyme is responsible for arginine methylation on various proteins, including histone H4. PRMT5 is a promising drug target, playing a role in the pathomechanism of several diseases, especially in the p
Externí odkaz:
https://doaj.org/article/a7636e5d8a9141b6b0e34365098a7950
Autor:
Rita Börzsei, Balázs Zoltán Zsidó, Mónika Bálint, Zsuzsanna Helyes, Erika Pintér, Csaba Hetényi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 6878 (2022)
Somatostatin (also named as growth hormone-inhibiting hormone or somatotropin release-inhibiting factor) is a regulatory peptide important for the proper functioning of the endocrine system, local inflammatory reactions, mood and motor coordination,
Externí odkaz:
https://doaj.org/article/df83628776a44c8b8605c77c396aed10
Autor:
Boglárka Kántás, Éva Szőke, Rita Börzsei, Péter Bánhegyi, Junaid Asghar, Lina Hudhud, Anita Steib, Ágnes Hunyady, Ádám Horváth, Angéla Kecskés, Éva Borbély, Csaba Hetényi, Gábor Pethő, Erika Pintér, Zsuzsanna Helyes
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Background: Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via its receptor subtype 4 (SST4) without influencing endocrine functions. Therefore, SST4 is considered to be a novel targ
Externí odkaz:
https://doaj.org/article/9adb7364d2ac44c6a60eb936e1d9b20a
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 988 (2021)
Transient receptor potential ankyrin 1 (TRPA1) is a transmembrane protein channeling the influx of calcium ions. As a polymodal nocisensor, TRPA1 can be activated by thermal, mechanical stimuli and a wide range of chemically damaging molecules includ
Externí odkaz:
https://doaj.org/article/ebccfa188a3a492cab36dd5f5978853a
Publikováno v:
Journal of Chemical Information and Modeling
Target-based design and repositioning are mainstream strategies of drug discovery. Numerous drug design and repositioning projects have been launched to fight the ongoing COVID-19 pandemic. The resulting drug candidates have often failed due to the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b22923ecdffa699cc0bc4c9d881bfa6
https://doi.org/10.1021/acs.jcim.1c00488
https://doi.org/10.1021/acs.jcim.1c00488
Autor:
Rita Börzsei, Éva Borbély, Boglárka Kántás, Lina Hudhud, Ádám Horváth, Éva Szőke, Csaba Hetényi, Zsuzsanna Helyes, Erika Pintér
Publikováno v:
Biochemical Pharmacology. 209:115419
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::766fbc7091cea5c1b5f81af0e8da172a
https://doi.org/10.1016/j.bcp.2023.115419
https://doi.org/10.1016/j.bcp.2023.115419
Autor:
Ágnes Hunyady, Ádám Horváth, Boglárka Kántás, Csaba Hetényi, Éva Borbély, Erika Pintér, Péter Bánhegyi, Éva Szőke, Rita Börzsei, Zsuzsanna Helyes
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 24
Volume 20
Issue 24
Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via the somatostatin sst4 receptor without endocrine actions. Therefore, sst4 is considered to be a novel target for drug development i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23eea4ca1bf8c1ae66d8da62657044e4