Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes

Autor: Colleen A. Lopez, Heba Hussain A. A. Al-Siddiqi, Ujang Purnama, Sonia Iftekhar, Arne A. N. Bruyneel, Matthew Kerr, Rabia Nazir, Maria da Luz Sousa Fialho, Sophia Malandraki-Miller, Rita Alonaizan, Fatemeh Kermani, Lisa C. Heather, Jan Czernuszka, Carolyn A. Carr

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) enable human cardiac cells to be studied in vitro, although they use glucose as their primary metabolic substrate and do not recapitulate the properties of adult cardiomy

Externí odkaz: https://doaj.org/article/620b82f11a04444ebfe740c6e09d998a

Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation

Autor: Rita Alonaizan, Carolyn Carr

Myocardial infarction is a leading cause of death globally due to the inability of the adult human heart to regenerate after injury. Cell therapy using cardiac-derived progenitor populations emerged about two decades ago with the aim of replacing cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c15b9c5a52bd5f3c543ab9e8342902
https://doi.org/10.1042/bst20210231

Improved cellular uptake of perfluorocarbon nanoparticles for in vivo murine cardiac 19F MRS/MRI and temporal tracking of progenitor cells

Autor: Louiza Potamiti, Ayman Al Haj Zen, Andrew M. Shaw, Eileen McNeill, Christakis Constantinides, Raquel Sainz-Urruela, Sergi Padilla-Parra, Kyriacos Kyriacou, Mangala Srinivas, Jyoti Patel, Ricardo Carnicer, Andreas Hadjisavvas, Carolyn A. Carr, Rita Alonaizan, Edyta Swider

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine
Nanomedicine-Nanotechnology Biology and Medicine, 18, pp. 391-401
Nanomedicine-Nanotechnology Biology and Medicine, 18, 391-401

Herein, we maximize the labeling efficiency of cardiac progenitor cells (CPCs) using perfluorocarbon nanoparticles (PFCE-NP) and 19F MRI detectability, determine the temporal dynamics of single-cell label uptake, quantify the temporal viability/fluor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d486e4a783169ce0af40b5f8919eea3b

MicroRNA-210-3P improves the survival potential of adult mouse cardiac progenitor cells

Autor: Nicola Smart, Carolyn A. Carr, Rita Alonaizan

Publikováno v: Journal of Molecular and Cellular Cardiology. 120:46

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42a0f59f5386d789f2db18e3c79cb834
https://doi.org/10.1016/j.yjmcc.2018.05.136