Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rita, West"'
Autor:
Rajappa S. Kenchappa, Panagiotis Mistriotis, Emily Wisniewski, Santanu Bhattacharya, Tanmay Kulkarni, Rita West, Amanda Luu, Meghan Conlon, Ernest Heimsath, James F. Crish, Hannah S. Picariello, Athanassios Dovas, Natanael Zarco, Montserrat Lara-Velazquez, Alfredo Quiñones-Hinojosa, John A. Hammer, Debrabrata Mukhopadhyay, Richard E. Cheney, Konstantinos Konstantopoulos, Peter Canoll, Steven S. Rosenfeld
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101802- (2020)
Summary: Invasion and proliferation are defining phenotypes of cancer, and in glioblastoma blocking one stimulates the other, implying that effective therapy must inhibit both, ideally through a single target that is also dispensable for normal tissu
Externí odkaz:
https://doaj.org/article/f2e6aa1145ad433d8b3c718e8b0b6bf0
Autor:
Rita West, Karen E. Parrish, William F. Elmquist, Alfredo Quinones Hinojosa, Jann N. Sarkaria, Steven S. Rosenfeld, Gautham Gampa, James F. Crish, Rajappa S. Kenchappa, Afroz S. Mohammad, Amanda Luu, Minjee Kim
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Glioblastoma, the most lethal primary brain cancer, is extremely proliferative and invasive. Tumor cells at tumor/brain-interface often exist behind a functionally intact blood-brain barrier (BBB), and so are shielded from exposure to therapeutic dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6a43e2c17460eebb1980045d988941
http://link.springer.com/article/10.1038/s41598-020-63494-7
http://link.springer.com/article/10.1038/s41598-020-63494-7
Autor:
Amanda Luu, David J. Odde, Vandana Rai, Rita West, Katarzyna Pogoda, Rajappa S. Kenchappa, Athanassios Dovas, Steven S. Rosenfeld, Paul A. Janmey, Thomas T. Egelhoff, Peter Canoll, Unnikrishnan M. Chandrasekharan, James F. Crish, Jan Lammerding, Hannah S. Picariello, Emily Bell, Mariah McMahon
Publikováno v:
Proceedings of the National Academy of Sciences. 116:15550-15559
The ability of glioblastoma to disperse through the brain contributes to its lethality, and blocking this behavior has been an appealing therapeutic approach. Although a number of proinvasive signaling pathways are active in glioblastoma, many are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c35f9d710596cc5a599663008b36c53
https://doi.org/10.1073/pnas.1902847116
https://doi.org/10.1073/pnas.1902847116
Autor:
Rajappa S, Kenchappa, Yi, Liu, Michael G, Argenziano, Matei A, Banu, Ann C, Mladek, Rita, West, Amanda, Luu, Alfredo, Quiñones-Hinojosa, Dolores, Hambardzumyan, Verline, Justilien, Michael, Leitges, Jann N, Sarkaria, Peter A, Sims, Peter, Canoll, Nicole R, Murray, Alan P, Fields, Steven S, Rosenfeld
Publikováno v:
Cell reports. 37(8)
We report that atypical protein kinase Cι (PKCι) is an oncogenic driver of glioblastoma (GBM). Deletion or inhibition of PKCι significantly impairs tumor growth and prolongs survival in murine GBM models. GBM cells expressing elevated PKCι signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8f2f5ade78b1b9106e9ac5310a1a6aa
https://pubmed.ncbi.nlm.nih.gov/34818553
https://pubmed.ncbi.nlm.nih.gov/34818553
Autor:
Rita West, Amanda Luu, Michael G. Argenziano, Matei A. Banu, Verline Justilien, Peter A. Sims, Alfredo Quinones-Hinojosa, Ann C. Mladek, Dolores Hambardzumyan, Yi Liu, Nicole R. Murray, Alan P. Fields, Steven S. Rosenfeld, Michael Leitges, Rajappa S. Kenchappa, Jann N. Sarkaria, Peter Canoll
Publikováno v:
Cell Reports. 37:110054
Summary We report that atypical protein kinase Cι (PKCι) is an oncogenic driver of glioblastoma (GBM). Deletion or inhibition of PKCι significantly impairs tumor growth and prolongs survival in murine GBM models. GBM cells expressing elevated PKC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93848b683e586e459808964638ce4fd3
https://doi.org/10.1016/j.celrep.2021.110054
https://doi.org/10.1016/j.celrep.2021.110054
Autor:
Yi Liu, Ann C. Mladek, Alan P. Fields, Rita West, Nicole R. Murray, Rajappa S. Kenchappa, Amanda Luu, Steven S. Rosenfeld, Jann N. Sarkaria
Publikováno v:
Neuro Oncol
In glioblastoma (GBM), invasion and proliferation are reciprocally related—e.g., targeting one stimulates the other. Thus, effective therapy for GBM requires finding targets that drive both invasion and proliferation and which are druggable, ideall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17183d8b17a143f80de26929f423f25d
https://doi.org/10.1093/neuonc/noz175.1189
https://doi.org/10.1093/neuonc/noz175.1189
Autor:
Leslie McKeon, Carolyn Hix, Mary T. Coleman, Paula Dycus, Rita West, Greg Ogrinc, Jonathan T. Huntington, Donna Hathaway, Cynthia McCurren
Publikováno v:
Quality management in health care. 18(3)
Background Practice-based learning and improvement (PBLI) combines the science of continuous quality improvement with the pragmatics of day-to-day clinical care delivery. PBLI is a core-learning domain in nursing and medical education. We developed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba23d84cff008a9039f0ae0155ac203
https://pubmed.ncbi.nlm.nih.gov/19609187
https://pubmed.ncbi.nlm.nih.gov/19609187
