Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Risto Lammintausta"'
Autor:
Mika Scheinin, Risto Lammintausta, Camilla Stjernschantz, Jouni Vuorinen, Pasi Tapanainen, Olavi Pelkonen, Terhi Lehtinen, Marita Kailajärvi, Jouko Uusitalo, Miia Turpeinen
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 14064-14075 (2013)
The objective of these investigations was to determine the possible effects of the novel selective estrogen receptor modulator, ospemifene, on cytochrome P450 (CYP)-mediated drug metabolism. Ospemifene underwent testing for possible effects on CYP en
Externí odkaz:
https://doaj.org/article/a788bfc9b5ac408ba34f2b49ea039e71
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 51:861-867
OBJECTIVE To characterize the pharmacokinetics of the oral, non-estrogen agent ospemifene, an estrogen agonist/antagonist with tissue-selective effects (also called a selective estrogen receptor modulator) that was recently approved for the treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3abf1ad43fcb97ce4de5cf26bd9e2f9
https://doi.org/10.5414/cp201925
https://doi.org/10.5414/cp201925
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 138:107-115
Ospemifene is a unique tissue-selective estrogen agonist/antagonist (also known as a selective estrogen receptor modulator [SERM]) with demonstrated efficacy in Phase 3 studies of postmenopausal women with vulvar and vaginal atrophy (VVA). This repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2c3f9aa9154363b075781705d7540c
https://doi.org/10.1016/j.jsbmb.2013.04.004
https://doi.org/10.1016/j.jsbmb.2013.04.004
Autor:
Pasi Koskimies, Risto Lammintausta, Jouni Vuorinen, Kirsi Katila, Mika Scheinin, Anne-Mari Aaltonen, Outi Saarni
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 51:787-794
Objective To assess the effect of concomitant food intake on the relative bioavailability of ospemifene and its main metabolite, 4-hydroxyospemifene, after single oral dosing. Methods This was an open-label, randomized, balanced, two-treatment (fed v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51225f169434b2473cbc526b87729746
https://doi.org/10.5414/cp201873
https://doi.org/10.5414/cp201873
Autor:
Miia Turpeinen, Mika Scheinin, Terhi Lehtinen, Pasi Tapanainen, Camilla Stjernschantz, Jouni Vuorinen, Marita Kailajärvi, Risto Lammintausta, Olavi Pelkonen, Jouko Uusitalo
Publikováno v:
International Journal of Molecular Sciences
Volume 14
Issue 7
Pages 14064-14075
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 14064-14075 (2013)
Volume 14
Issue 7
Pages 14064-14075
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 14064-14075 (2013)
The objective of these investigations was to determine the possible effects of the novel selective estrogen receptor modulator, ospemifene, on cytochrome P450 (CYP)-mediated drug metabolism. Ospemifene underwent testing for possible effects on CYP en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61adb9239508801f6d030457f1a53aa6
https://doi.org/10.3390/ijms140714064
https://doi.org/10.3390/ijms140714064
Autor:
Miia Turpeinen, Jouko Uusitalo, Olavi Pelkonen, Ari Tolonen, Pasi Koskimies, Risto Lammintausta
Publikováno v:
Drug Metabolism and Personalized Therapy. 31
Background Metabolite profiles of ospemifene, a novel nonsteroidal selective estrogen receptor modulator, were surveyed as part of its development. Methods The pharmacokinetics of ospemifene and its two major, pharmacologically active metabolites 4-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6eb769c98d7e7cdd7e03934a143159
https://doi.org/10.1515/dmpt-2015-0020
https://doi.org/10.1515/dmpt-2015-0020
Publikováno v:
Acta Pharmacologica et Toxicologica. 45:20-24
The pharmacokinetics of nitrazepam in saliva and serum was studied in 12 healthy volunteers after a single administration of a 5 mg nitrazepam tablet. The binding of nitrazepam to plasma proteins was determined 4 hours after the administration by ult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f737a0a26e6f286b3ab180431f4908b
https://doi.org/10.1111/j.1600-0773.1979.tb02354.x
https://doi.org/10.1111/j.1600-0773.1979.tb02354.x
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 327:58-67
The anti-inflammatory and antiestrogenic action of fispemifene [Z-2-{2-[4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxy]ethoxy}-ethanol], a novel selective estrogen receptor modulator (SERM), was tested on the Noble rat model of chronic nonbacterial prost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982cbeb9eb5645451a08ff5a5cb2a4b1
https://doi.org/10.1124/jpet.108.139501
https://doi.org/10.1124/jpet.108.139501
Publikováno v:
Journal of Urology. 168:2263-2268
We treat neonatally estrogenized rats and aromatase over expressing AROM+ male mice with infravesical obstruction using the specific aromatase inhibitors finrozole and letrozole, and analyzed whether developmentally induced alterations in urodynamics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bda8cfc87f2f208d466b4bd93db4029
https://doi.org/10.1016/s0022-5347(05)64368-6
https://doi.org/10.1016/s0022-5347(05)64368-6
Autor:
Olavi Pelkonen, Risto Lammintausta, Kalapudas Arja, Marja Södervall, Karjalainen Arto Johannes
Publikováno v:
European Journal of Pharmaceutical Sciences. 11:109-131
A series of long-chained diarylalkylimidazoles and diarylalkyltriazoles were synthesized and evaluated for the inhibitory potency for aromatase (estrogen synthetase) activity in human placental microsomes. The relative specificity of inhibition was e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f53fff7e73f99663307699af673f8cd
https://doi.org/10.1016/s0928-0987(00)00074-9
https://doi.org/10.1016/s0928-0987(00)00074-9