Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Risto Cukalevski"'
Autor:
Tanja Weiffert, Georg Meisl, Samo Curk, Risto Cukalevski, Anđela Šarić, Tuomas P. J. Knowles, Sara Linse
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Amyloid formation is linked to devastating neurodegenerative diseases, motivating detailed studies of the mechanisms of amyloid formation. For Aβ, the peptide associated with Alzheimer’s disease, the mechanism and rate of aggregation have been est
Externí odkaz:
https://doaj.org/article/d37c9ffbb60b4063b3536fe69e8183fc
Autor:
Sara Linse, Christopher M. Dobson, Paolo Arosio, Tuomas P. J. Knowles, Remco T. P. van Cruchten, Xiaoting Yang, Mikael Akke, Ulrich Weininger, Risto Cukalevski, Cecilia Emanuelsson, Cecilia Månsson
Publikováno v:
Biochemistry, 57, 32, pp. 4891-4902
Biochemistry, 57, 4891-4902
Biochemistry, 57, 4891-4902
Item does not contain fulltext The human molecular chaperone DNAJB6, an oligomeric protein with a conserved S/T-rich region, is an efficient suppressor of amyloid fibril formation by highly aggregation-prone peptides such as the Abeta and polyQ pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13340ca3f3eeab4d6f6ed60a30b942b
https://hdl.handle.net/2066/196205
https://hdl.handle.net/2066/196205
Autor:
Tuomas P. J. Knowles, Katja Bernfur, Risto Cukalevski, Birgitta Frohm, Georg Meisl, Ulrich Weininger, Sara Linse, Xiaoting Yang
Publikováno v:
Chemical Science. 6:4215-4233
The assembly of proteins into amyloid fibrils, a phenomenon central to several currently incurable human diseases, is a process of high specificity that commonly tolerates only a low level of sequence mismatch in the component polypeptides. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c92245168f3047385453d9c9b5f2a897
https://doi.org/10.1039/c4sc02517b
https://doi.org/10.1039/c4sc02517b
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide
Autor:
Thomas C. T. Michaels, Christopher M. Dobson, Sara Linse, Samuel I. A. Cohen, Anđela Šarić, Risto Cukalevski, Tuomas P. J. Knowles, Mattias Törnquist, Michele Vendruscolo, Alexander K. Buell
Publikováno v:
Nature chemistry. 10(5)
Mapping free-energy landscapes has proved to be a powerful tool for studying reaction mechanisms. Many complex biomolecular assembly processes, however, have remained challenging to access using this approach, including the aggregation of peptides an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ad803e693da8fd12325542f49f5d3c
https://pubmed.ncbi.nlm.nih.gov/29581486
https://pubmed.ncbi.nlm.nih.gov/29581486
Autor:
Tommy Cedervall, Cecilia Oslakovic, Risto Cukalevski, Björn Dahlbäck, Sara Linse, Martin Lundqvist
Publikováno v:
Langmuir. 27:14360-14369
Nanoparticles are widely used in the pharmaceutical and food industries, but the consequences of exposure to the human body have not been thoroughly investigated. Apolipoprotein A-I (apoAI), the major protein in high-density lipoprotein (HDL), and ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d740295c5070975420faac317d1ca887
https://doi.org/10.1021/la203290a
https://doi.org/10.1021/la203290a
Autor:
Risto Cukalevski, Christopher J.R. Dunning, Tord Berggård, Tommy Cedervall, Silvia A. Ferreira
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
A thorough understanding of how proteins induce nanoparticle (NP) aggregation is crucial when designing in vitro and in vivo assays and interpreting experimental results. This knowledge is also crucial when developing nano-applications and formulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9df24eec59cbaf465918e0fd915b244
P2‐108: THE NOVEL EFFECT OF CSF AND APOE4 ON THE AGGREGATION KINETICS OF Aβ42 IN ALZHEIMER'S DISEASE
Autor:
Eden Rebecca Padayachee, Sara Linse, Ulf Andreasson, Risto Cukalevski, Erik Portelius, Kaj Blennow, Henrik Zetterberg
Publikováno v:
Alzheimer's & Dementia. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77e132a8c994389c73f8b633b9c62b8f
https://doi.org/10.1016/j.jalz.2014.05.783
https://doi.org/10.1016/j.jalz.2014.05.783
Publikováno v:
Journal of the American Chemical Society. 136(1)
The aggregation of the amyloid beta peptide, Aβ42, implicated in Alzheimer's disease, is characterized by a lag phase followed by a rapid growth phase. Conventional methods to study this reaction are not sensitive to events taking place early in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba1b1e32a36ab733d14504fda569c9c
https://pubmed.ncbi.nlm.nih.gov/24313551
https://pubmed.ncbi.nlm.nih.gov/24313551
Aggregation of the amyloid β-protein (Aβ) is believed to be involved in Alzheimer's disease pathogenesis. Here we have investigated the importance of the aromatic rings at positions 19 and 20 for the aggregation rate and mechanism by substituting p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483a7babe09a16d70334074fc1c359ab
https://europepmc.org/articles/PMC3526965/
https://europepmc.org/articles/PMC3526965/
Autor:
Astrid Gräslund, Sara Linse, Anna Wahlström, Julius Rebek, Jueri Jarvet, Jens Danielsson, Risto Cukalevski, Hideki Onagi
Publikováno v:
Biochemistry. 51(21)
Alzheimer's disease involves progressive neuronal loss. Linked to the disease is the amyloid beta (A beta) peptide, a 38-43-amino acid peptide found in extracellular amyloid plaques in the brain. Cyclodextrins are nontoxic, cone-shaped oligosaccharid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cfbe792030ef872ebce20517794988
https://pubmed.ncbi.nlm.nih.gov/22554145
https://pubmed.ncbi.nlm.nih.gov/22554145