Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rishi R Shah"'
Autor:
Philip G. Humphreys, Niall A. Anderson, Paul Bamborough, Andrew Baxter, Chun-wa Chung, Rosa Cookson, Peter D. Craggs, Toryn Dalton, Julie C. L. Fournier, Laurie J. Gordon, Heather F. Gray, Matthew W. Gray, Richard Gregory, David J. Hirst, Craig Jamieson, Katherine L. Jones, Hripsimee Kessedjian, David Lugo, Grant McGonagle, Vipulkumar K. Patel, Christopher Patten, Darren L. Poole, Rab K. Prinjha, Cesar Ramirez-Molina, Inmaculada Rioja, Gail Seal, Kayleigh A. J. Stafford, Rishi R. Shah, Daniel Tape, Natalie H. Theodoulou, Laura Tomlinson, Sabri Ukuser, Ian D. Wall, Natalie Wellaway, Gemma White
Publikováno v:
Journal of Medicinal Chemistry. 65:15174-15207
The bromodomain and extra terminal (BET) family of proteins are an integral part of human epigenome regulation, the dysregulation of which is implicated in multiple oncology and inflammatory diseases. Disrupting the BET family bromodomain acetyl-lysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247c403b556d0cdc2a89bb75345904c1
https://doi.org/10.1021/acs.jmedchem.2c01102
https://doi.org/10.1021/acs.jmedchem.2c01102
Autor:
Christopher R. Wellaway, Ian R. Baldwin, Paul Bamborough, Daniel Barker, Michelle A. Bartholomew, Chun-wa Chung, Birgit Dümpelfeld, John P. Evans, Neal J. Fazakerley, Paul Homes, Steven P. Keeling, Xiao Q. Lewell, Finlay W. McNab, Joanne Morley, Deborah Needham, Margarete Neu, Antoon J. M. van Oosterhout, Anshu Pal, Friedrich B. M. Reinhard, Francesco Rianjongdee, Craig M. Robertson, Paul Rowland, Rishi R. Shah, Emma B. Sherriff, Lisa A. Sloan, Simon Teague, Daniel A. Thomas, Natalie Wellaway, Justyna Wojno-Picon, James M. Woolven, Diane M. Coe
Publikováno v:
Journal of Medicinal Chemistry. 65:633-664
The Janus family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) play an essential role in the receptor signaling of cytokines that have been implicated in the pathogenesis of severe asthma, and there is emerging interest in the development of small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25612a371cd9b4befcdd69bdbd64fbaa
https://doi.org/10.1021/acs.jmedchem.1c01765
https://doi.org/10.1021/acs.jmedchem.1c01765
Autor:
Patricia F Medeiros, Mythily Vimal, Vipulkumar Kantibhai Patel, John Evans, Neil R Carlson, Antonia J. Lewis, Paul Bamborough, Katherine L Jones, Jane E Smith, Michael O'Sullivan, Scott McCleary, Darren J. Mitchell, Heather Barnett, Chun-wa Chung, Gang Yao, Anthony W. J. Cooper, Rab K. Prinjha, Laurie Gordon, Mahnoor Mahmood, Peter D. Craggs, Isobel L Harada, Rino A Bit, Natalie Wellaway, Armelle Le Gall, Robert J. Watson, Tony W Dean, Dominique Amans, Ian D. Wall, Kayleigh A J Stafford, Dave Lugo, Matthew J Lindon, Rishi R Shah, David Jonathan Hirst, Chris Patten, Darren L Poole, Jack A Brown, Philip G Humphreys, Robert P Davis, Christopher Roland Wellaway, Pamela J Thomas
Publikováno v:
Journal of Medicinal Chemistry. 63:714-746
The bromodomain and extraterminal (BET) family of bromodomain-containing proteins are important regulators of the epigenome through their ability to recognize N-acetyl lysine (KAc) post-translational modifications on histone tails. These interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb502737af78aed357d47636c87313d
https://doi.org/10.1021/acs.jmedchem.9b01670
https://doi.org/10.1021/acs.jmedchem.9b01670
Autor:
Diane M. Coe, Andrei Mihut, Michelle Anne Bartholomew, Joanna M. Redmond, John P. Evans, Rishi R. Shah, John A. Murphy, Malini Menon
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115326
PROTACs have recently emerged as a novel paradigm in drug discovery. They can hijack existing biological machinery to selectively degrade proteins of interest, in a catalytic fashion. Here we describe the design, optimisation and biological activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ddbf5bcb860bd75799cc32b7f74012
https://doi.org/10.1016/j.bmc.2020.115326
https://doi.org/10.1016/j.bmc.2020.115326
Autor:
Murray R. Snyder, Alexis Cenko, Matthew Constantino, Ned J. Davis, Robert M. Nordlund, Jason D. Metzger, Joseph Shea, M.K. Smith, Scott A. Simpson, Rishi R. Shah, Christopher O'Brien
Publikováno v:
29th AIAA Applied Aerodynamics Conference.
In order to maximize stealth, most new military fighter/attack aircraft are designed to carry weapons internally. Associated wind tunnel testing of stores inside an internal bomb bay or cavity can be problematic due to the use of a sting or strut to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b59b2d40f0b4666298af676c7d9284c7
https://doi.org/10.2514/6.2011-3159
https://doi.org/10.2514/6.2011-3159
Autor:
Krumholz HM; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.; Center for Infection and Immunity, Yale School of Medicine, New Haven, Connecticut.; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.; Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut., Wu Y; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.; Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut., Sawano M; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut., Shah R; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.; Department of Applied Mathematics, Yale College, New Haven, Connecticut., Zhou T; Yale School of Medicine, New Haven, Connecticut., Arun AS; Yale School of Medicine, New Haven, Connecticut., Khosla P; Yale School of Medicine, New Haven, Connecticut., Kaleem S; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Vashist A; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.; The College at the University of Chicago, Chicago, Illinois., Bhattacharjee B; Center for Infection and Immunity, Yale School of Medicine, New Haven, Connecticut.; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut., Ding Q; College of Health and Human Sciences, Purdue University, West Lafayette, Indiana., Lu Y; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut., Caraballo C; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.; Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut., Warner F; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut., Huang C; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut., Herrin J; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut., Putrino D; Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York., Hertz D; Independent Researcher, Los Angeles, California., Dressen B; REACT19., Iwasaki A; Center for Infection and Immunity, Yale School of Medicine, New Haven, Connecticut.; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut.; Howard Hughes Medical Institute, Chevy Chase, Maryland.
Publikováno v:
MedRxiv : the preprint server for health sciences [medRxiv] 2023 Nov 10. Date of Electronic Publication: 2023 Nov 10.
Autor:
Chandrasekera D; Department of Physiology, HeartOtago, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Shah R; Department of Physiology, HeartOtago, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., van Hout I; Department of Physiology, HeartOtago, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., De Jonge W; Department of Physiology, HeartOtago, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Bunton R; Cardiothoracic Surgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand., Parry D; Cardiothoracic Surgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand., Davis P; Cardiothoracic Surgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand., Katare R; Department of Physiology, HeartOtago, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Publikováno v:
Nanotheranostics [Nanotheranostics] 2023 Apr 02; Vol. 7 (4), pp. 345-352. Date of Electronic Publication: 2023 Apr 02 (Print Publication: 2023).
Autor:
Iqbal N; Robin Phillips' Fistula Research Unit, St Mark's Hospital, London HA1 3UJ, UK., Shah R; Robin Phillips' Fistula Research Unit, St Mark's Hospital, London HA1 3UJ, UK., Alrubaiy L; Robin Phillips' Fistula Research Unit, St Mark's Hospital, London HA1 3UJ, UK., Tozer P; Robin Phillips' Fistula Research Unit, St Mark's Hospital, London HA1 3UJ, UK.
Publikováno v:
Clinics and practice [Clin Pract] 2022 Aug 15; Vol. 12 (4), pp. 628-639. Date of Electronic Publication: 2022 Aug 15.
Autor:
Nie J; Department of Urology, Yale University School of Medicine, New Haven, CT; Yale University School of Medicine, New Haven, CT., Hsiang W; Department of Urology, University of California-San Francisco, San Francisco, CA., Marks V; Department of Urology, Yale University School of Medicine, New Haven, CT; Yale University School of Medicine, New Haven, CT., Laditi F; Department of Urology, Yale University School of Medicine, New Haven, CT; Yale University School of Medicine, New Haven, CT., Varghese A; Department of Urology, Yale University School of Medicine, New Haven, CT., Umer W; Department of Urology, Yale University School of Medicine, New Haven, CT., Haleem A; Department of Urology, Yale University School of Medicine, New Haven, CT., Mothy D; Department of Urology, Yale University School of Medicine, New Haven, CT., Wang H; Department of Urology, Yale University School of Medicine, New Haven, CT., Patel R; Department of Urology, Yale University School of Medicine, New Haven, CT., Pan W; Department of Urology, Yale University School of Medicine, New Haven, CT., Shah R; Department of Urology, Yale University School of Medicine, New Haven, CT., Khan S; Department of Urology, Yale University School of Medicine, New Haven, CT., Singh R; Department of Urology, Yale University School of Medicine, New Haven, CT., Golla V; Department of Urology, Duke School of Medicine, Durham, NC., Cavallo J; Department of Urology, Yale University School of Medicine, New Haven, CT; Yale University School of Medicine, New Haven, CT., Breyer BN; Department of Urology, University of California-San Francisco, San Francisco, CA., Leapman MS; Department of Urology, Yale University School of Medicine, New Haven, CT; Yale University School of Medicine, New Haven, CT. Electronic address: michael.leapman@yale.edu.
Publikováno v:
Urology [Urology] 2022 Jun; Vol. 164, pp. 112-117. Date of Electronic Publication: 2022 Mar 08.
Autor:
Mehta P; Department of Quality Assurance, Bharati Vidyapeeth University, Poona College of Pharmacy, Erandwane, Pune, Maharashtra, India., Shah R; School of Life Sciences, University of Bradford, Bradford, West Yorkshire, UK., Lohidasan S; Department of Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy, Erandwane, Maharashtra, India., Mahadik KR; Department of Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy, Erandwane, Maharashtra, India.
Publikováno v:
Journal of traditional and complementary medicine [J Tradit Complement Med] 2015 Jan 28; Vol. 5 (4), pp. 207-27. Date of Electronic Publication: 2015 Jan 28 (Print Publication: 2015).