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Long-lasting memory of cellular immunity in a chronic myeloid leukemia patient maintains molecular response 5 after cessation of dasatinib

Autor: Tatsuro Jo, Youhei Kaneko, Sadaharu Irie, Shizuka Hayashi, Haruna Shioya, Risa Hayase, Jun Taguchi, Kensuke Horio, Kazuhiro Noguchi

Publikováno v: Oncology Letters

Tyrosine kinase inhibitors (TKIs), including imatinib, dasatinib and nilotinib are primarily used in the initial treatment of chronic phase (CP)-chronic myeloid leukemia (CML), as CMLs harbor the BCR-ABL fusion product. An increased number of lymphoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db121c2ae4344e171cce9bc4f3fe17ae
https://pubmed.ncbi.nlm.nih.gov/29435021

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Cytotoxic Immune Response Can be Obtained Earlier in Chronic Phase Chronic Myeloid Leukemia Patients Treated with Dasatinib Than with Other Tyrosine Kinase Inhibitors

Autor: Haruna Shioya, Risa Hayase, Yohei Kaneko, Shizuka Hayashi, Kensuke Horio, Sadaharu Irie, Tatsuro Jo, Jun Taguchi, Kazuhiro Noguchi

Publikováno v: Blood. 132:3016-3016

Introduction: Generation of BCR-ABL fusion gene by reciprocal translocation of chromosomes 9 and 22 immortalizes hematopoietic stem cells by mechanisms such as activation of the JAK-STAT pathway, translational activation of BCL-XL, and inhibition of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53295b2a0d1530fa2a97215c1b25a639
https://doi.org/10.1182/blood-2018-99-113316

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