Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Risa Akizuki"'
Autor:
Ryohei Maruhashi, Shohei Hamada, Hiroaki Eguchi, Risa Akizuki, Takumi Furuta, Toshiyuki Matsunaga, Kenji Ichihara, Satoshi Endo, Akira Ikari
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
The aberrant expression of claudins (CLDNs), which are tight junctional proteins, is seen in various solid tumors, but the regulatory mechanisms and their pathophysiological role are not well understood. Both CLDN1 and CLDN11 were highly expressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a628e05fb3475af54c5a76783c82817
http://link.springer.com/article/10.1038/s41598-019-50276-z
http://link.springer.com/article/10.1038/s41598-019-50276-z
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:247-254
Abnormal expression of the tight junctional components claudins (CLDNs) is observed in various malignant tissues. We reported recently that CLDN18 expression is down-regulated in human lung adenocarcinoma tissues. In the present study, we investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab31c2b2a0231c56f7940414e8ce070f
https://doi.org/10.1248/bpb.b18-00670
https://doi.org/10.1248/bpb.b18-00670
Autor:
Haruka Nasako, Ayaka Ito, Risa Akizuki, Yuta Yoshino, Akira Ikari, Yui Takashina, Satoshi Endo, Hiroaki Eguchi, Toshiyuki Matsunaga
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6582, p 6582 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 12
International Journal of Molecular Sciences
Volume 22
Issue 12
Claudin-2 (CLDN2), a tight junctional protein, is involved in the chemoresistance in a three-dimensional spheroid culture model of human lung adenocarcinoma A549 cells. However, the mechanism has not been fully clarified. We found that the knockdown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0fe0a5e7f450478057e16a9552991b
https://pubmed.ncbi.nlm.nih.gov/34205320
https://pubmed.ncbi.nlm.nih.gov/34205320
Autor:
Hiroaki Eguchi, Takumi Furuta, Satoshi Endo, Akira Ikari, Risa Akizuki, Ryohei Maruhashi, Toshiyuki Matsunaga, Mitsutoshi Tsukimoto
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
Chemoresistance is a serious issue in the therapy of many cancers, but the molecular mechanism is little understood. The mRNA level of occludin (OCLN), a tight junctional protein, was increased in the cisplatin (CDDP), doxorubicin (DXR), 7-ethyl-10-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64aef542ae25905da8ed88f2754ecf5f
http://link.springer.com/article/10.1038/s41598-018-33566-w
http://link.springer.com/article/10.1038/s41598-018-33566-w
Autor:
Akira Ikari, Hiroaki Eguchi, Risa Akizuki, Toshiyuki Matsunaga, Kazuki Kitabatake, Ryohei Maruhashi, Satoshi Endo, Mitsutoshi Tsukimoto, Takumi Furuta
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1865:769-780
Chemotherapy resistance is a major problem in the treatment of cancer, but the underlying mechanisms are not fully understood. We found that the expression levels of claudin-1 (CLDN1) and 3, tight junctional proteins, are upregulated in cisplatin (CD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2351a5c408f0bd64de02e90a8846838b
https://doi.org/10.1016/j.bbamcr.2018.03.001
https://doi.org/10.1016/j.bbamcr.2018.03.001
Autor:
Saeko Taga, Satoshi Endo, Miki Okamoto, Akira Ikari, Risa Akizuki, Toshiyuki Matsunaga, Asami Hichino
Publikováno v:
Journal of Biological Chemistry. 292:2411-2421
Claudin-2 is highly expressed in lung adenocarcinoma tissues and increases proliferation in adenocarcinoma cells. The chemicals that reduce claudin-2 expression may have anti-cancer effects, but such therapeutic medicines have not been developed. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6c2c1d4dc46527949b39235ab200b6
https://doi.org/10.1074/jbc.m116.762807
https://doi.org/10.1074/jbc.m116.762807
Autor:
Yoshinobu Ishikawa, Toshiyuki Matsunaga, Tomohiro Asai, Akira Ikari, Haruka Nasako, Yui Takashina, Risa Akizuki, Mikako Shirouzu, Takehiro Shinoda, Satoshi Endo
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1867:118642
Claudin-2 (CLDN2), a tight junctional protein, is involved in the chemoresistance in spheroid culture models of human lung adenocarcinoma A549 cells. However, there is no chemical which can improve the sensitivity to anticancer drugs. So far, we repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1a00c1782bd985f66be868f731f1a1
https://doi.org/10.1016/j.bbamcr.2019.118642
https://doi.org/10.1016/j.bbamcr.2019.118642
Autor:
Risa Akizuki, Ryohei Maruhashi, Akira Ikari, Yasuhiro Yamazaki, Hideki Sakai, Toshiyuki Matsunaga, Tomonari Sato, Satoshi Endo, Masahiko Yamaguchi
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1865(3)
Claudins, tight junctional proteins, regulate the paracellular permeability of ions and small molecules. Claudin-2 is highly expressed in human lung adenocarcinoma cells and is involved in the up-regulation of cell proliferation. However, the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b04b823203b79f93fbd4a298c398ea
https://pubmed.ncbi.nlm.nih.gov/29247669
https://pubmed.ncbi.nlm.nih.gov/29247669
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1864(2)
Abnormal expression of claudin (CLDN) subtypes has been reported in various solid cancers. However, it is unknown which subtype plays a key role in the regulation of proliferation in cancer cells. The expression of CLDN3-5, 7, and 18 in human lung sq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b401c64119be0235a1e1fcdb3f77fb
https://pubmed.ncbi.nlm.nih.gov/27884700
https://pubmed.ncbi.nlm.nih.gov/27884700
Autor:
Ryo Watanabe, Yasuhiro Yamazaki, Satoshi Endo, Akira Ikari, Risa Akizuki, Saeko Taga, Shun Shimobaba, Toshiyuki Matsunaga, Junko Sugatani, Asami Hichino, Masahiko Yamaguchi
Publikováno v:
Biochimica et biophysica acta. 1863(6 Pt)
Abnormal expression of claudin subtypes has been reported in various cancers. However, the pathological role of each claudin has not been clarified in detail. Claudin-18 was absent in human non-small cell and small cell lung cancers, although it is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bece3b387823d44a603a365892dbf9
https://pubmed.ncbi.nlm.nih.gov/26919807
https://pubmed.ncbi.nlm.nih.gov/26919807