Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ripal Gaudana"'
Publikováno v:
Ophthalmology and Eye Diseases, Vol 2009, Iss 1, Pp 21-31 (2009)
Objective: To delineate the plasma pharmacokinetics and determine the corneal uptake of valine based stereoisomeric dipeptide prodrugs of acyclovir (ACV) in rats. Methods: Male Sprague-Dawley rats were used for the study. Pharmacokinetics of ACV, L-v
Externí odkaz:
https://doaj.org/article/68eef9ebbed647cd9c51195d698f1c50
Publikováno v:
The AAPS Journal. 20
Different types of imaging modalities are used in the diagnosis of ocular cancer. Selection of an imaging modality is based on the features of a tumor as well as the inherent characteristics of the imaging technique. It is vital to select an appropri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f9a974eb9ecb977f13255de4f6cc01
https://doi.org/10.1208/s12248-018-0259-9
https://doi.org/10.1208/s12248-018-0259-9
Publikováno v:
Journal of Drug Delivery
Journal of Drug Delivery, Vol 2011 (2011)
Journal of Drug Delivery, Vol 2011 (2011)
The objective of the present study is to formulate and characterize a nanoparticulate-based formulation of a macromolecule in a hydrophobic ion pairing (HIP) complex form. So far, HIP complexation approach has been studied only for proteins with mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f626a8c122b51d3266e5d393821e5b74
https://doi.org/10.1155/2011/458128
https://doi.org/10.1155/2011/458128
Publikováno v:
Clinical Research and Regulatory Affairs. 26:65-72
The objective of this work was to study the disposition kinetics of valine-valine-acyclovir (VVACV), a dipeptide ester prodrug of acyclovir following intravenous and oral administrations in rat. A validated LC-MS/MS analytical method was developed fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8cc4e2288af9f322900d698a275d8f
https://doi.org/10.1080/10601330903200684
https://doi.org/10.1080/10601330903200684
Publikováno v:
International Journal of Pharmaceutics. 361:118-124
The objective of this study was to synthesize and evaluate novel enzymatically stable dipeptide prodrugs for improved absorption of acyclovir. l-Valine-l-valine-acyclovir (LLACV), l-valine-d-valine-acyclovir (LDACV), d-valine-l-valine-acyclovir (DLAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69f0221f9313372efa9ac5fa4e0c26e
https://doi.org/10.1016/j.ijpharm.2008.05.024
https://doi.org/10.1016/j.ijpharm.2008.05.024
Publikováno v:
Excipient Applications in Formulation Design and Drug Delivery ISBN: 9783319202051
Active agents have been considered the main ingredients of any therapeutic product since the early ages of formulation technology. However, the importance of the inactive ingredients has been realized during the last three decades. With the developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76f71d14fd7185ebbe37e9237530893f
https://doi.org/10.1007/978-3-319-20206-8_12
https://doi.org/10.1007/978-3-319-20206-8_12
IgG-Fab fragment, a model antibody protein was hydrophobically modified by a novel approach of ion-pairing complexation. Three different sulphated ion-pairing agents were utilised including sodium dodecyl sulphate, taurocholic acid and dextran sulpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41afade32e3fbd2658a19a222b0f080
https://europepmc.org/articles/PMC4407684/
https://europepmc.org/articles/PMC4407684/
Publikováno v:
Scopus-Elsevier
Formulation development of protein therapeutics using polymeric nanoparticles has found very little success in recent years. Major formulation challenges include rapid denaturation, susceptibility to lose bioactivity in presence of organic solvents a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c601b16907b028a465695fb07fa0959f
https://europepmc.org/articles/PMC4406287/
https://europepmc.org/articles/PMC4406287/
Ocular drug therapy has always been considered as a major challenge in the field of drug delivery. The presence of blood ocular barriers and efflux pumps has imposed a great concern as well. Various vision threatening disorders require a long term th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f5fa763a79f6c478b31c4bcd94a846
https://europepmc.org/articles/PMC4407700/
https://europepmc.org/articles/PMC4407700/
Publikováno v:
Prodrugs and Targeted Delivery: Towards Better ADME Properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61da9db245b3cbefb61058334d71a4e8
https://doi.org/10.1002/9783527633166.ch8
https://doi.org/10.1002/9783527633166.ch8