Discovery of TRPA1 Antagonist GDC-6599 : Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.

Autor: Terrett JA, Ly JQ, Katavolos P, Hasselgren C, Laing S, Zhong F, Villemure E, Déry M; Paraza Pharma, Incorporated, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada., Larouche-Gauthier R; Paraza Pharma, Incorporated, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada., Chen H, Shore DG, Lee WP, Suto E, Johnson K, Brooks M; Department of Population Medicine and Diagnostic Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York 14853, United States., Stablein A; Department of Population Medicine and Diagnostic Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York 14853, United States., Beaumier F; Paraza Pharma, Incorporated, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada., Constantineau-Forget L; Paraza Pharma, Incorporated, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada., Grand-Maître C; Paraza Pharma, Incorporated, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada., Lépissier L; Paraza Pharma, Incorporated, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada., Ciblat S; Paraza Pharma, Incorporated, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada., Sturino C; Paraza Pharma, Incorporated, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada., Chen Y; Pharmaron-Beijing Company Limited, 6 Taihe Road BDA, Beijing 100176, PR China., Hu B; Pharmaron-Beijing Company Limited, 6 Taihe Road BDA, Beijing 100176, PR China., Elstrott J, Gandham V, Joseph V, Booler H, Cain G, Chou C, Fullerton A, Lepherd M, Stainton S, Torres E, Urban K, Yu L, Zhong Y, Bao L, Chou KJ, Lin J, Zhang W, La H, Liu L, Mulder T, Chen J, Chernov-Rogan T, Johnson AR, Hackos DH, Leahey R, Shields SD, Balestrini A, Riol-Blanco L, Safina BS, Volgraf M, Magnuson S, Kakiuchi-Kiyota S

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3287-3306. Date of Electronic Publication: 2024 Mar 03.

Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function.

Autor: Jung M; Department of OMNI Bioinformatics, Genentech, Inc., South San Francisco, CA, USA., Dourado M; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, USA., Maksymetz J; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, USA., Jacobson A; Department of Immunology Discovery, Genentech, Inc., South San Francisco, CA, USA., Laufer BI; Department of OMNI Bioinformatics, Genentech, Inc., South San Francisco, CA, USA., Baca M; Department of Pathology, Genentech, Inc., South San Francisco, CA, USA., Foreman O; Department of Pathology, Genentech, Inc., South San Francisco, CA, USA., Hackos DH; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, USA. hackos.david@gene.com., Riol-Blanco L; Department of Immunology Discovery, Genentech, Inc., South San Francisco, CA, USA. lorenarb@23andme.com., Kaminker JS; Department of OMNI Bioinformatics, Genentech, Inc., South San Francisco, CA, USA. kaminker@gene.com.

Publikováno v: Nature communications [Nat Commun] 2023 Jan 23; Vol. 14 (1), pp. 366. Date of Electronic Publication: 2023 Jan 23.

A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.

Autor: Balestrini A; Department of Immunology Discovery, Genentech, Inc., South San Francisco, CA., Joseph V; Department of Biomedical Imaging, Genentech, Inc., South San Francisco, CA., Dourado M; Department of Neuroscience, Genentech, Inc., South San Francisco, CA., Reese RM; Department of Neuroscience, Genentech, Inc., South San Francisco, CA., Shields SD; Department of Neuroscience, Genentech, Inc., South San Francisco, CA., Rougé L; Department of Structural Biology, Genentech, Inc., South San Francisco, CA., Bravo DD; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA., Chernov-Rogan T; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA., Austin CD; Department of Pathology, Genentech, Inc., South San Francisco, CA., Chen H; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA., Wang L; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA., Villemure E; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA., Shore DGM; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA., Verma VA; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA., Hu B; Pharmaron-Beijing Co. Ltd., BDA, Beijing, People's Republic of China., Chen Y; Pharmaron-Beijing Co. Ltd., BDA, Beijing, People's Republic of China., Leong L; Department of Pathology, Genentech, Inc., South San Francisco, CA., Bjornson C; Department of Pathology, Genentech, Inc., South San Francisco, CA., Hötzel K; Department of Pathology, Genentech, Inc., South San Francisco, CA., Gogineni A; Department of Biomedical Imaging, Genentech, Inc., South San Francisco, CA., Lee WP; Department of Translational Immunology, Genentech, Inc., South San Francisco, CA., Suto E; Department of Translational Immunology, Genentech, Inc., South San Francisco, CA., Wu X; Department of Translational Immunology, Genentech, Inc., South San Francisco, CA., Liu J; Department of Translational Immunology, Genentech, Inc., South San Francisco, CA., Zhang J; Department of Translational Immunology, Genentech, Inc., South San Francisco, CA., Gandham V; Department of Biomedical Imaging, Genentech, Inc., South San Francisco, CA., Wang J; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA., Payandeh J; Department of Structural Biology, Genentech, Inc., South San Francisco, CA., Ciferri C; Department of Structural Biology, Genentech, Inc., South San Francisco, CA., Estevez A; Department of Structural Biology, Genentech, Inc., South San Francisco, CA., Arthur CP; Department of Structural Biology, Genentech, Inc., South San Francisco, CA., Kortmann J; Department of Immunology Discovery, Genentech, Inc., South San Francisco, CA., Wong RL; Department of Immunology Discovery, Genentech, Inc., South San Francisco, CA., Heredia JE; Department of Immunology Discovery, Genentech, Inc., South San Francisco, CA., Doerr J; Department of Molecular Biology, Genentech, Inc., South San Francisco, CA., Jung M; Department of OMNI Bioinformatics, Genentech, Inc., South San Francisco, CA., Vander Heiden JA; Department of OMNI Bioinformatics, Genentech, Inc., South San Francisco, CA., Roose-Girma M; Department of Molecular Biology, Genentech, Inc., South San Francisco, CA., Tam L; Department of Molecular Biology, Genentech, Inc., South San Francisco, CA., Barck KH; Department of Biomedical Imaging, Genentech, Inc., South San Francisco, CA., Carano RAD; Department of Biomedical Imaging, Genentech, Inc., South San Francisco, CA., Ding HT; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, CA., Brillantes B; Department of Biomolecular Resources, Genentech, Inc., South San Francisco, CA., Tam C; Department of Biomolecular Resources, Genentech, Inc., South San Francisco, CA., Yang X; Department of Product Development Biometric Biostatistics, Genentech, Inc., South San Francisco, CA., Gao SS; Department of Clinical Imaging, Genentech, Inc., South San Francisco, CA., Ly JQ; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA., Liu L; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA., Chen L; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA., Liederer BM; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA., Lin JH; Department of Early Clinical Development, Genentech, Inc., South San Francisco, CA., Magnuson S; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA., Chen J; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA., Hackos DH; Department of Neuroscience, Genentech, Inc., South San Francisco, CA., Elstrott J; Department of Biomedical Imaging, Genentech, Inc., South San Francisco, CA., Rohou A; Department of Structural Biology, Genentech, Inc., South San Francisco, CA., Safina BS; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA., Volgraf M; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA., Bauer RN; Department of OMNI-Biomarker Development, Genentech, Inc., South San Francisco, CA., Riol-Blanco L; Department of Immunology Discovery, Genentech, Inc., South San Francisco, CA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2021 Apr 05; Vol. 218 (4).

The influence of sex on neuroimmune communication, pain, and physiology.

Autor: Alexander, Shevon N.¹ (AUTHOR), Green, Audrey R.¹ (AUTHOR), Debner, Emily K.¹ (AUTHOR), Ramos Freitas, Lindsey E.¹ (AUTHOR), Abdelhadi, Hanna M. K.¹ (AUTHOR), Szabo-Pardi, Thomas A.¹ (AUTHOR), Burton, Michael D.¹ (AUTHOR) michael.burton@utdallas.edu

Publikováno v: Biology of Sex Differences. 10/22/2024, Vol. 15 Issue 1, p1-25. 25p.

Single-cell sequencing of the vermiform appendix during development identifies transcriptional relationships with appendicitis in preschool children.

Autor: Meng, Lingdu¹ (AUTHOR), Yang, Yifan¹ (AUTHOR), He, Shiwei² (AUTHOR), Chen, Huifen¹ (AUTHOR), Zhan, Yong¹ (AUTHOR), Yang, Ran¹ (AUTHOR), Li, Zifeng¹ (AUTHOR), Zhu, Jiajie¹ (AUTHOR), Zhou, Jin¹ (AUTHOR), Li, Yi¹ (AUTHOR), Xie, Lulu¹ (AUTHOR), Chen, Gong¹ (AUTHOR), Zheng, Shan¹ (AUTHOR) szheng@shmu.edu.cn, Yao, Xiaoying³ (AUTHOR) 13916738653@139.com, Dong, Rui¹ (AUTHOR) rdong@fudan.edu.cn

Publikováno v: BMC Medicine. 9/12/2024, Vol. 22 Issue 1, p1-21. 21p.