Overlap in signaling between Smoothened and the α subunit of the heterotrimeric G protein G₁₃

Autor: Guo, X, Riobo-Del Galdo, NA, Kim, EJ, Grant, GR, Manning, DR

The Hedgehog family of morphogens has long been known to utilize, through the 7-transmembrane protein Smoothened (Smo), the heterotrimeric G protein Gi in both canonical and noncanonical forms of signaling. Other G proteins, while not specifically ut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ac7e056785af8d97de5772a383ba7527
https://eprints.whiterose.ac.uk/130851/3/journal.pone.0197442.pdf

The β-Secretase BACE1 Drives Fibroblast Activation in Systemic Sclerosis through the APP/β-Catenin/Notch Signaling Axis.

Autor: Wasson CW; Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom., De Lorenzis E; Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Clavane EM; Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom., Ross RL; Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom., Walker KA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom., Caballero-Ruiz B; Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom., Antinozzi C; Unit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Rome, Italy., Wells R; Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom., Migneco G; Department of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA., Brown JMY; Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom., Turvey SJ; Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom., Simmons KJ; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom., Riobo-Del Galdo NA; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom; Leeds Institute of Medical Research, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom., Di Luigi L; Unit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Rome, Italy., McKimmie CS; Leeds Institute of Medical Research, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom., Del Galdo F; Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom; Scleroderma Programme, NIHR Leeds Musculoskeletal Biomedical Research Centre, Leeds, United Kingdom. Electronic address: f.delgaldo@leeds.ac.uk., Meakin PJ; Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom. Electronic address: p.j.meakin@leeds.ac.uk.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2024 Oct; Vol. 144 (10), pp. 2197-2210.e4. Date of Electronic Publication: 2024 Apr 01.

Signaling Switching from Hedgehog-GLI to MAPK Signaling Potentially Serves as a Compensatory Mechanism in Melanoma Cell Lines Resistant to GANT-61.

Autor: Piteša N; Ruđer Bošković Institute, Division of Molecular Medicine, 10 000 Zagreb, Croatia., Kurtović M; Ruđer Bošković Institute, Division of Molecular Medicine, 10 000 Zagreb, Croatia., Bartoniček N; The Garvan Institute of Medical Research, Genome Informatics, Genomics & Epigenetics Division, 384 Victoria St., Darlinghurst, NSW 2010, Australia.; The Kinghorn Centre for Clinical Genomics, 370 Victoria St., Darlinghurst, NSW 2010, Australia., Gkotsi DS; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.; Astbury Centre for Molecular Structural Biology, University of Leeds, Leeds LS2 9JT, UK., Čonkaš J; Ruđer Bošković Institute, Division of Molecular Medicine, 10 000 Zagreb, Croatia., Petrić T; Ruđer Bošković Institute, Division of Molecular Medicine, 10 000 Zagreb, Croatia., Musani V; Ruđer Bošković Institute, Division of Molecular Medicine, 10 000 Zagreb, Croatia., Ozretić P; Ruđer Bošković Institute, Division of Molecular Medicine, 10 000 Zagreb, Croatia., Riobo-Del Galdo NA; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.; Astbury Centre for Molecular Structural Biology, University of Leeds, Leeds LS2 9JT, UK.; Leeds Institute of Medical Research, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK.; Leeds Cancer Research Centre, University of Leeds, Leeds LS2 9JT, UK., Sabol M; Ruđer Bošković Institute, Division of Molecular Medicine, 10 000 Zagreb, Croatia.

Publikováno v: Biomedicines [Biomedicines] 2023 May 03; Vol. 11 (5). Date of Electronic Publication: 2023 May 03.

Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability.

Autor: Caballero-Ruiz B; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Gkotsi DS; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS29JT, UK., Ollerton H; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS29JT, UK., Morales-Alcala CC; Leeds Institute for Medical Research, School of Medicine, University of Leeds, Leeds LS29JT, UK., Bordone R; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Jenkins GML; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS29JT, UK., Di Magno L; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Canettieri G; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.; Institute Pasteur Italy-Cenci Bolognetti Foundation, 00161 Rome, Italy., Riobo-Del Galdo NA; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS29JT, UK.; Leeds Institute for Medical Research, School of Medicine, University of Leeds, Leeds LS29JT, UK.; Leeds Cancer Research Centre, University of Leeds, Leeds LS29JT, UK.; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds LS29JT, UK.

Publikováno v: Cancers [Cancers (Basel)] 2023 Jan 06; Vol. 15 (2). Date of Electronic Publication: 2023 Jan 06.

Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation.

Autor: Wasson CW; Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS29JT, UK., Caballero-Ruiz B; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS29JT, UK.; Department of Molecular Medicine, Sapienza University of Rome, 00196 Rome, Italy., Gillespie J; Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS29JT, UK., Derrett-Smith E; Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London NW32PF, UK., Mankouri J; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS29JT, UK., Denton CP; Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London NW32PF, UK., Canettieri G; Department of Molecular Medicine, Sapienza University of Rome, 00196 Rome, Italy., Riobo-Del Galdo NA; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS29JT, UK.; Leeds Institute of Medical Research, Faculty of Medicine and Health, University of Leeds, Leeds LS29JT, UK., Del Galdo F; Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS29JT, UK.; Scleroderma Programme, NIHR Leeds Musculoskeletal Biomedical Research Centre, Leeds LS29JT, UK.

Publikováno v: Cells [Cells] 2022 Feb 03; Vol. 11 (3). Date of Electronic Publication: 2022 Feb 03.