Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Rio P. Juni"'
Autor:
Noelia Lozano-Vidal, Laura Stanicek, Diewertje I. Bink, Rio P. Juni, Aukie Hooglugt, Veerle Kremer, Philippa Phelp, Anke van Bergen, Alyson W. MacInnes, Stefanie Dimmeler, Reinier A. Boon
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Age-related diseases pose great challenges to health care systems worldwide. During aging, endothelial senescence increases the risk for cardiovascular disease. Recently, it was described that Phosphatase 1 Nuclear Targeting Subunit (PNUTS)
Externí odkaz:
https://doaj.org/article/c23b2adb9f504a019c2402bcb783687d
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2024)
Heart failure with preserved ejection fraction (HFpEF) is the largest unmet clinical need in cardiovascular medicine. Despite decades of research, the treatment option for HFpEF is still limited, indicating our ongoing incomplete understanding on the
Externí odkaz:
https://doaj.org/article/dd0fbfee4e90401bac94aaf8453bc925
Autor:
Alessandra Tammaro, Eileen G. Daniels, Iman M. Hu, Kelly C. ‘t Hart, Kim Reid, Rio P. Juni, Loes M. Butter, Goutham Vasam, Rashmi Kamble, Aldo Jongejan, Richard I. Aviv, Joris J.T.H. Roelofs, Eleonora Aronica, Reinier A. Boon, Keir J. Menzies, Riekelt H. Houtkooper, Georges E. Janssens
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108681- (2024)
Summary: Aging increases the risk of age-related diseases, imposing substantial healthcare and personal costs. Targeting fundamental aging mechanisms pharmacologically can promote healthy aging and reduce this disease susceptibility. In this work, we
Externí odkaz:
https://doaj.org/article/42cc145abf8d478f88355c37c49e69d9
Autor:
Laween Uthman, Anna Homayr, Rio P. Juni, Eva L. Spin, Raphaela Kerindongo, Marleen Boomsma, Markus W. Hollmann, Benedikt Preckel, Pieter Koolwijk, Victor W.M. van Hinsbergh, Coert J. Zuurbier, Martin Albrecht, Nina C. Weber
Publikováno v:
Cellular Physiology and Biochemistry, Vol 53, Iss 5, Pp 865-886 (2019)
Externí odkaz:
https://doaj.org/article/233c649f9b894beab1e1f03e1375d2bb
Autor:
Rio P. Juni, PhD, Diederik W.D. Kuster, PhD, Max Goebel, MSc, Michiel Helmes, PhD, René J.P. Musters, PhD, Jolanda van der Velden, PhD, Pieter Koolwijk, PhD, Walter J. Paulus, MD, PhD, Victor W.M. van Hinsbergh, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 5, Pp 575-591 (2019)
Summary: The positive findings of the EMPA-REG OUTCOME trial (Randomized, Placebo-Controlled Cardiovascular Outcome Trial of Empagliflozin) on heart failure (HF) outcome in patients with type 2 diabetes mellitus suggest a direct effect of empaglifloz
Externí odkaz:
https://doaj.org/article/3ed290af219b4583a9eb3ca67de459dc
Publikováno v:
Non-coding RNA Research, Vol 2, Iss 1, Pp 45-55 (2017)
Heart failure is a complex syndrome involving various pathophysiological processes. An increasing body of evidence shows that the myocardial microvasculature is essential for the homeostasis state and that a decompensated heart is associated with mic
Externí odkaz:
https://doaj.org/article/13fbb3a180ee4a90b6222d51c0868aad
Autor:
Rio P. Juni, Jordy M.M. Kocken, Ricardo C. Abreu, Lara Ottaviani, Tim Davalan, Burcu Duygu, Ella M. Poels, Aliaksei Vasilevich, Jana C. Hegenbarth, Mahesh Appari, Nicole Bitsch, Serve Olieslagers, Dorien M. Schrijvers, Monika Stoll, Joerg Heineke, Jan de Boer, Leon J. de Windt, Paula A. da Costa Martins
Publikováno v:
Juni, R P, Kocken, J M M, Abreu, R C, Ottaviani, L, Davalan, T, Duygu, B, Poels, E M, Vasilevich, A, Hegenbarth, J C, Appari, M, Bitsch, N, Olieslagers, S, Schrijvers, D M, Stoll, M, Heineke, J, de Boer, J, de Windt, L J & da Costa Martins, P A 2023, ' MicroRNA-216a is essential for cardiac angiogenesis ', Molecular Therapy, vol. 31, no. 6, pp. 1807-1828 . https://doi.org/10.1016/j.ymthe.2023.04.007
Molecular Therapy, 31(6), 1807-1828. Nature Publishing Group
Molecular Therapy, 31(6), 1807-1828. Nature Publishing Group
While it is experimentally supported that impaired myocardial vascularization contributes to a mismatch between myocardial oxygen demand and supply, a mechanistic basis for disruption of coordinated tissue growth and angiogenesis in heart failure rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4cdfbed4c34e65e260ef80ffb25f52
https://research.vumc.nl/en/publications/afc667a8-f509-4264-b38a-61a3f329b22d
https://research.vumc.nl/en/publications/afc667a8-f509-4264-b38a-61a3f329b22d
Publikováno v:
Juni, R P, 't Hart, K C, Houtkooper, R H & Boon, R A 2022, ' Long noncoding RNAs in cardiometabolic disorders ', FEBS Letters, vol. 596, no. 11, pp. 1367-1387 . https://doi.org/10.1002/1873-3468.14370
The advancement of medical technology has led not only to an increase in life expectancy but also to a rise in aging-related diseases. Aging promotes metabolic disorders, in turn affecting cardiovascular health. Derailment of biological processes in
Autor:
Pieter Koolwijk, Diederik W. D. Kuster, Rushd Al-Shama, Etto C. Eringa, Jolanda van der Velden, Victor W.M. van Hinsbergh, Rio P. Juni, Marc G. Vervloet, Henrike M Hamer
Publikováno v:
Juni, R P, Al-Shama, R, Kuster, D W D, van der Velden, J, Hamer, H M, Vervloet, M G, Eringa, E C, Koolwijk, P & van Hinsbergh, V W M 2021, ' Empagliflozin restores chronic kidney disease-induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction ', Kidney International, vol. 99, no. 5, pp. 1088-1101 . https://doi.org/10.1016/j.kint.2020.12.013
Kidney International, 99(5), 1088-1101. Elsevier Science
Kidney International, 99(5), 1088-1101. Nature Publishing Group
Kidney International, 99(5), 1088-1101. Elsevier Science
Kidney International, 99(5), 1088-1101. Nature Publishing Group
Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly prevalent in patients with heart failure, particularly in those with preserved ejection fraction. CKD is associated with endothelial dysfunction, however, whethe
Autor:
Lara Ottaviani, Rio P. Juni, Ricardo C. de Abreu, Marida Sansonetti, Vasco Sampaio-Pinto, Julie Halkein, Jana C. Hegenbarth, Nadja Ring, Kevin Knoops, Jordy M.M. Kocken, Carlos de Jesus, Auriane C. Ernault, Hamid el Azzouzi, Frank Rühle, Servé Olieslagers, Hugo Fernandes, Lino Ferreira, Luca Braga, Monika Stoll, Diana S. Nascimento, Leon J. de Windt, Paula A. da Costa Martins
Publikováno v:
Mol Ther
Ottaviani, L, Juni, R P, de Abreu, R C, Sansonetti, M, Sampaio-Pinto, V, Halkein, J, Hegenbarth, J C, Ring, N, Knoops, K, Kocken, J M M, Jesus, C D, Ernault, A C, el Azzouzi, H, Rühle, F, Olieslagers, S, Fernandes, H, Ferreira, L, Braga, L, Stoll, M, Nascimento, D S, de Windt, L J & da Costa Martins, P A 2022, ' Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells ', Molecular Therapy, vol. 30, no. 6, pp. 2257-2273 . https://doi.org/10.1016/j.ymthe.2022.03.002
Molecular Therapy, 30(6), 2257-2273. Nature Publishing Group
Molecular Therapy, 30(6), 2257-2273. Cell Press
Molecular Therapy
Ottaviani, L, Juni, R P, de Abreu, R C, Sansonetti, M, Sampaio-Pinto, V, Halkein, J, Hegenbarth, J C, Ring, N, Knoops, K, Kocken, J M M, Jesus, C D, Ernault, A C, el Azzouzi, H, Rühle, F, Olieslagers, S, Fernandes, H, Ferreira, L, Braga, L, Stoll, M, Nascimento, D S, de Windt, L J & da Costa Martins, P A 2022, ' Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells ', Molecular Therapy, vol. 30, no. 6, pp. 2257-2273 . https://doi.org/10.1016/j.ymthe.2022.03.002
Molecular Therapy, 30(6), 2257-2273. Nature Publishing Group
Molecular Therapy, 30(6), 2257-2273. Cell Press
Molecular Therapy
As mediators of intercellular communication, extracellular vesicles containing molecular cargo, such as microRNAs, are secreted by cells and taken up by recipient cells to influence their cellular phenotype and function. Here we report that cardiac s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bd065645cb8387b1bf10159632794d
https://europepmc.org/articles/PMC9171264/
https://europepmc.org/articles/PMC9171264/