Výsledky vyhledávání - "Rinu Shrestha"

An Isomer of Galidesivir That Potently Inhibits Influenza Viruses and Members of the Bunyavirales Order

Autor: Kevin J. Sparrow, Rinu Shrestha, James M. Wood, Keith Clinch, Brett L. Hurst, Hong Wang, Brian B. Gowen, Justin G. Julander, E. Bart Tarbet, Alice M. McSweeney, Vernon K. Ward, Gary B. Evans, Lawrence. D. Harris

Publikováno v: ACS Medicinal Chemistry Letters. 14:506-513

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4d43179c43e8630cced245bf2621c5f
https://doi.org/10.1021/acsmedchemlett.3c00048

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Inhibition of the DENV2 and ZIKV RNA polymerases by Galidesivir triphosphate measured using a continuous fluorescence assay

Autor: Sandesh Deshpande, Wenjuan Huo, Rinu Shrestha, Kevin Sparrow, Gary B. Evans, Lawrence D. Harris, Richard L. Kingston, Esther M. M. Bulloch

Millions of people are infected by the Dengue and Zika viruses each year, which can result in serious illness, permanent disability or death. There are currently no FDA-approved antivirals for treating infection by these viruses. Galidesivir is an ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf16530901d210e09e7934585641209b
https://doi.org/10.1101/2022.12.20.521302

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Gadolinium Complexes Attached to Poly Ethoxy Ethyl Glycinamide (PEE‐G) Dendrons: Magnetic Resonance Imaging Contrast Agents with Increased Relaxivity

Autor: Phillip M. Rendle, Paul H. Teesdale-Spittle, Andrew R. Lewis, Rinu Shrestha

Publikováno v: ChemPlusChem. 85:1881-1892

A range of poly ethoxy ethyl glycinamide (PEE-G) dendron scaffolds with gadolinium (III) complexes attached were synthesized with a focus on product purity and high Gd(III) loading. The nuclear magnetic resonance relaxivity of these products was meas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65aec32c14105f10100766a7e50ad82
https://doi.org/10.1002/cplu.202000409

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The Synthesis and Anti-tumour Properties of Poly Ethoxy Ethyl Glycinamide (PEE-G) Scaffolds with Multiple PD-1 Peptides Attached

Autor: Kathryn J. Farrand, Paul H. Teesdale-Spittle, Peter D. Mace, Rinu Shrestha, Emma V. Petley, Sam A. Jamieson, Ian F. Hermans, Wanting Jiao, Phillip M. Rendle

Publikováno v: ChemMedChem. 15(13)

Multivalent structures can provide multiple interactions at a target site and improve binding affinity. The multivalent presentation of the anti-tumour heptapeptide, SNTSESF, was investigated. This peptide's activity has been attributed to blockade o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e7a265284b880523a74e8fdfecb70e
https://pubmed.ncbi.nlm.nih.gov/32400116

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