Distinct phosphorylation signals drive acceptor versus self-ubiquitination selection by Parkin

Autor: Hadi D, Kathryn R. Barber, Karen M. Dunkerley, Salzano G, Roya Tadayon, Gary S. Shaw, Rintala-Dempsey Ac, Helen Walden

The RBR E3 ligase parkin is recruited to the outer mitochondrial membrane (OMM) during oxidative stress where it becomes activated and ubiquitinates numerous proteins. Parkin activation involves binding of a phosphorylated ubiquitin (pUb), followed b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9019c1d984b273c0c536de11159a2816
https://doi.org/10.1101/2021.06.01.446590

Capturing the catalytic intermediates of parkin ubiquitination.

Autor: Connelly EM; Department of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada., Rintala-Dempsey AC; Department of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada., Gundogdu M; School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Freeman EA; Department of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada., Koszela J; School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Aguirre JD; Department of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada., Zhu G; Department of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada., Kämäräinen O; School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Tadayon R; Department of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada., Walden H; School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Shaw GS; Department of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Aug 06; Vol. 121 (32), pp. e2403114121. Date of Electronic Publication: 2024 Jul 30.

Eukaryotic stand-alone pseudouridine synthases - RNA modifying enzymes and emerging regulators of gene expression?

Autor: Rintala-Dempsey AC; a Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry , University of Lethbridge , Lethbridge , AB , Canada., Kothe U; a Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry , University of Lethbridge , Lethbridge , AB , Canada.

Publikováno v: RNA biology [RNA Biol] 2017 Sep 02; Vol. 14 (9), pp. 1185-1196. Date of Electronic Publication: 2017 Jan 03.

Insights into S100 target specificity examined by a new interaction between S100A11 and annexin A2.

Autor: Rintala-Dempsey AC; Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada N6A 5C1., Santamaria-Kisiel L, Liao Y, Lajoie G, Shaw GS

Publikováno v: Biochemistry [Biochemistry] 2006 Dec 12; Vol. 45 (49), pp. 14695-705.