Zobrazeno 1 - 10
of 564
pro vyhledávání: '"Rinse K. Weersma"'
Autor:
Asier Fernández-Pato, Trishla Sinha, Ranko Gacesa, Sergio Andreu-Sánchez, Milla F. Brandao Gois, Jody Gelderloos-Arends, Dianne B. H. Jansen, Marloes Kruk, Martin Jaeger, Leo A. B. Joosten, Mihai G. Netea, Rinse K. Weersma, Cisca Wijmenga, Hermie J. M. Harmsen, Jingyuan Fu, Alexandra Zhernakova, Alexander Kurilshikov
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The lack of standardization in the methods of DNA extraction from fecal samples represents the major source of experimental variation in the microbiome research field. In this study, we aimed to compare the metagenomic profiles and microbiom
Externí odkaz:
https://doaj.org/article/52385fca2f7241a7beafe6bc3f4fd066
Autor:
Shixian Hu, Arno R. Bourgonje, Ranko Gacesa, Bernadien H. Jansen, Johannes R. Björk, Amber Bangma, Iwan J. Hidding, Hendrik M. van Dullemen, Marijn C. Visschedijk, Klaas Nico Faber, Gerard Dijkstra, Hermie J. M. Harmsen, Eleonora A. M. Festen, Arnau Vich Vila, Lieke M. Spekhorst, Rinse K. Weersma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Disrupted host-microbe interactions at the mucosal level are key to the pathophysiology of IBD. This study aimed to comprehensively examine crosstalk between mucosal gene expression and microbiota in patients with IBD. To study tissue-specif
Externí odkaz:
https://doaj.org/article/7d585f4cd17d4027b8c1cce58bfea380
Autor:
Femke M. Prins, Iwan J. Hidding, Marjolein A.Y. Klaassen, Valerie Collij, Johannes P.D. Schultheiss, Werna T.C. Uniken Venema, Amber Bangma, Jurne B. Aardema, Bernadien H. Jansen, Wout G.N. Mares, Ben J.M. Witteman, Eleonora A.M. Festen, Gerard Dijkstra, Marijn C. Visschedijk, Herma H. Fidder, Arnau Vich Vila, Bas Oldenburg, Ranko Gacesa, Rinse K. Weersma
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Emerging evidence suggests the gut microbiome’s potential in predicting response to biologic treatments in patients with inflammatory bowel disease (IBD). In this prospective study, we aimed to predict treatment response to vedolizumab and ustekinu
Externí odkaz:
https://doaj.org/article/75c0bb382cf0416fa8df443a241eb914
Autor:
Shuyan Zhang, J. Casper Swarte, Ranko Gacesa, Tim J. Knobbe, Daan Kremer, Bernadien H. Jansen, Martin H. de Borst, Hermie J. M. Harmsen, Michiel E. Erasmus, Erik A. M. Verschuuren, Stephan J. L. Bakker, C. Tji Gan, Rinse K. Weersma, Johannes R. Björk
Publikováno v:
mSystems, Vol 9, Iss 6 (2024)
ABSTRACT Gut dysbiosis has been associated with impaired outcomes in liver and kidney transplant recipients, but the gut microbiome of lung transplant recipients has not been extensively explored. We assessed the gut microbiome in 64 fecal samples fr
Externí odkaz:
https://doaj.org/article/33dfc51e43fa4a4fbd184b36da11afaa
Autor:
J. Casper Swarte, Tim J. Knobbe, Johannes R. Björk, Ranko Gacesa, Lianne M. Nieuwenhuis, Shuyan Zhang, Arnau Vich Vila, Daan Kremer, Rianne M. Douwes, Adrian Post, Evelien E. Quint, Robert A. Pol, Bernadien H. Jansen, TransplantLines investigators, Martin H. de Borst, Vincent E. de Meijer, Hans Blokzijl, Stefan P. Berger, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Stephan J. L. Bakker, Rinse K. Weersma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Kidney transplant recipients (KTR) have impaired health-related quality of life (HRQoL) and suffer from intestinal dysbiosis. Increasing evidence shows that gut health and HRQoL are tightly related in the general population. Here, we investi
Externí odkaz:
https://doaj.org/article/cdeb8a6b39384ab38c6f1bc5cddf08f1
Autor:
Raphael R. Fagundes, Gabriela Bravo-Ruiseco, Shixian Hu, Sarah J. Kierans, Rinse K. Weersma, Cormac T. Taylor, Gerard Dijkstra, Hermie J. M. Harmsen, Klaas Nico Faber
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionIntestinal epithelial cells produce interleukin-18 (IL-18), a key factor in promoting epithelial barrier integrity. Here, we analyzed the potential role of gut bacteria and the hypoxia-inducible factor 1α (HIF1α) pathway in regulating m
Externí odkaz:
https://doaj.org/article/5f37fa2f42fd405ca3fe8ff2670a47dc
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTThe human gut microbiota continues to demonstrate its importance in human health and disease, largely owing to the countless number of studies investigating the fecal microbiota. Underrepresented in these studies, however, is the role played
Externí odkaz:
https://doaj.org/article/306ed3afb8bc46489cee2c484819286f
Autor:
Alessia Visconti, Niccolò Rossi, Helena Deriš, Karla A Lee, Maja Hanić, Irena Trbojević-Akmačić, Andrew M. Thomas, Laura A. Bolte, Johannes R. Björk, Jahlisa S. Hooiveld-Noeken, Ruth Board, Mark Harland, Julia Newton-Bishop, Mark Harries, Joseph J. Sacco, Paul Lorigan, Heather M. Shaw, Elisabeth G.E. de Vries, Rudolf S.N. Fehrmann, Rinse K. Weersma, Tim D. Spector, Paul Nathan, Geke A. P. Hospers, Peter Sasieni, Veronique Bataille, Gordan Lauc, Mario Falchi
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of melanoma and other cancers. However, no reliable biomarker of survival or response has entered the clinic to identify those patients with melanoma who are mo
Externí odkaz:
https://doaj.org/article/50b511b7f9af46e6993f096da9d33865
Autor:
Milla F. Brandao Gois, Asier Fernández-Pato, Anke Huss, Ranko Gacesa, Cisca Wijmenga, Rinse K. Weersma, Jingyuan Fu, Roel C. H. Vermeulen, Alexandra Zhernakova, Virissa C. Lenters, Alexander Kurilshikov
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The rising use of pesticides in modern agriculture has led to a shift in disease burden in which exposure to these chemicals plays an increasingly important role. The human gut microbiome, which is partially responsible for the biotransformation of x
Externí odkaz:
https://doaj.org/article/a043aeaeec2f4fb1b51e93d8bd057504
Autor:
Yue Zhang, Sergio Andreu-Sánchez, Nadira Vadaq, Daoming Wang, Vasiliki Matzaraki, Wouter A. van der Heijden, Ranko Gacesa, Rinse K. Weersma, Alexandra Zhernakova, Linos Vandekerckhove, Quirijn de Mast, Leo A. B. Joosten, Mihai G. Netea, André J. A. M. van der Ven, Jingyuan Fu
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
BackgroundPeople living with human immunodeficiency virus (PLHIV) are exposed to chronic immune dysregulation, even when virus replication is suppressed by antiretroviral therapy (ART). Given the emerging role of the gut microbiome in immunity, we hy
Externí odkaz:
https://doaj.org/article/95e0698f27d345e292c73b1565aa8964