Výsledky vyhledávání - "Rino S. Seedor"

Akademický článek

Characterizing metastatic uveal melanoma patients who develop symptomatic brain metastases

Autor: Alexander Z. Wei, Matan Uriel, Agata Porcu, Michael P. Manos, Ann C. Mercurio, Michael M. Caplan, Liam Hulse, Rino S. Seedor, Marta Holovatska, Jasmine Francis, Shaheer A. Khan, Diana E. McDonnell, Dmitry Bogomolny, Takami Sato, Brian P. Marr, Rizwan Haq, Marlana Orloff, Alexander Shoushtari, Richard D. Carvajal

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Metastatic uveal melanoma (mUM) is an advanced ocular malignancy characterized by a hepatotropic pattern of spread. As the incidence of brain metastases (BM) in mUM patients has been thought to be low, routine CNS surveillance has not been recommende

Externí odkaz: https://doaj.org/article/bec726a3073a437abfa5b4f685292205

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Genetic Landscape and Emerging Therapies in Uveal Melanoma

Autor: Rino S. Seedor, Takami Sato, Marlana Orloff

Publikováno v: Cancers
Cancers, Vol 13, Iss 5503, p 5503 (2021)

Simple Summary Uveal melanoma is the most common primary intraocular malignancy in adults. Unfortunately, metastasis develops in up to 50% of cases and outcomes are poor for these patients. In this review, we discuss our current understanding of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d084b3cf24dc630cba11e125f69a7676
http://europepmc.org/articles/PMC8582814

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Randomized phase II study of adjuvant sunitinib or valproic acid in high-risk patients with uveal melanoma: The final analysis of cohort 1

Autor: Rino S. Seedor, Marlana M. Orloff, Erin Sharpe-Mills, Liam Hulse, Reshma Shelat, Ayako Shimada, Inna Chervoneva, Carol L. Shields, Jerry A. Shields, Michael J. Mastrangelo, Takami Sato

Publikováno v: Journal of Clinical Oncology. 40:9586-9586

9586 Background: Despite successful treatment of primary uveal melanoma (UM), tumors with monosomy 3 and 8q amplification (M3 + 8q amp) or DecisionDx-UM Class 2 have high metastatic death rates. We report the final analysis of Cohort 1 in the randomi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3888f2919bc60f4602d3123325d14261
https://doi.org/10.1200/jco.2022.40.16_suppl.9586

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Prospective Comparison of Geriatric Assessment and Provider's Assessment of Older Adults With Metastatic Breast Cancer in the Community

Autor: Rino S Seedor, Caitlin R Meeker, Bianca Lewis, Elizabeth A Handorf, Kelly A Filchner, Ramya Varadarajan, Jack Hensold, Aruna Padmanabhan, Benjamin Negin, Kenneth Blankstein, Neha R Chawla, Wei (Frank) Song, Jessica Epstein, Jennifer Winn, Lori J Goldstein, Efrat Dotan

Publikováno v: The oncologist. 27(2)

Background Geriatric assessment (GA) is recommended for evaluating fitness of an older adult with cancer. Our objective was to prospectively evaluate the gaps that exist in the assessment of older adults with metastatic breast cancer (OA-MBC) in comm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8e0b0cda6ab27c8d7bc016ad33f12e
https://pubmed.ncbi.nlm.nih.gov/35641214

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Clinical trial in progress: Phase II trial of defactinib (VS-6063) combined with VS-6766 (CH5126766) in patients with metastatic uveal melanoma

Autor: J. Silvio Gutkind, Takami Sato, Erin Sharpe-Mills, Andrew E. Aplin, Mizue Terai, Haley Klose, Rino S. Seedor, Marlana Orloff, Michael J. Mastrangelo

Publikováno v: Journal of Clinical Oncology. 39:TPS9588-TPS9588

TPS9588 Background: Despite successful treatment of primary uveal melanomas (UM), up to 50% of patients subsequently develop systemic metastasis, with the liver involved in up to 90% of patients. Currently there is no US FDA-approved treatment for me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6dd90de88403a19799ebf89553c043d
https://doi.org/10.1200/jco.2021.39.15_suppl.tps9588

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Prospective study comparing self-administered geriatric assessment to provider’s routine clinical assessment of older patients with metastatic breast cancer treated at community oncology practices

Autor: Kelly Filchner, Rino S. Seedor, Efrat Dotan, Bianca Lewis, Jennifer S. Winn, Caitlin R. Meeker, Lori J. Goldstein, Elizabeth Handorf

Publikováno v: Journal of Clinical Oncology. 38:12029-12029

12029 Background: Geriatric Assessment (GA) is recommended for evaluating an older cancer patient’s (pt) fitness for treatment. We conducted a prospective study evaluating the current gaps that exist in the assessment of older pts with metastatic b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5e246ecd36401f6d3b12047a5c60985
https://doi.org/10.1200/jco.2020.38.15_suppl.12029

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The prevalence of hereditary pancreatitis mutations in families with pancreatic cancer

Autor: Elizabeth Handorf, John Garcia, Michael J. Hall, Rino S. Seedor, Kim Rainey, Waleed Iqbal, Edward D. Esplin, Rebecca Truty, Sanjeevani Arora, Steven Lincoln, Michelle Savage, Andrea Forman

Publikováno v: Journal of Clinical Oncology. 37:e15728-e15728

e15728 Background: Germline pathogenic variants (PV) in hereditary cancer risk genes are found in ~10-15% of pancreatic adenocarcinomas/cancers (PC), but most cases of familial PC have no identifiable genetic cause. Chronic pancreatitis is an establi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5e695c0a74a67cdbdd758bcb86c91fb
https://doi.org/10.1200/jco.2019.37.15_suppl.e15728

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Liver-directed treatment for patients with uveal melanoma hepatic metastasis: A retrospective analysis of overall survival

Autor: Allison Gradone, Erin Sharpe-Mills, Takami Sato, Marlana Orloff, Michael J. Mastrangelo, David J. Eschelman, Robert D. Adamo, Anjum Amjad, Rino S. Seedor, Carol L. Shields, Ryan M. Weight, Jerry A. Shields, Carin F. Gonsalves

Publikováno v: Journal of Clinical Oncology. 36:9592-9592

9592Background: Despite successful treatment of primary uveal melanomas, up to 50% of patients subsequently develop systemic metastasis, with the liver involved in up to 90% of patients. At our ins...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04e956e6e28ac656221a2ae57f974a45
https://doi.org/10.1200/jco.2018.36.15_suppl.9592

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