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Akademický článek

Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Spaceflight can change metabolic, immunological, and biological homeostasis and cause skin rashes and irritation, yet the molecular basis remains unclear. To investigate the impact of short-duration spaceflight on the skin, we conducted skin

Externí odkaz: https://doaj.org/article/60b54f6af6b24c2694a1e6a88a4f7b8d

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Akademický článek

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Ultra High-plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles

Autor: Shilah A. Bonnett, Alyssa B. Rosenbloom, Giang T. Ong, Mark Conner, Aric B.E. Rininger, Daniel Newhouse, Felicia New, Chi Q. Phan, Saskia Ilcisin, Hiromi Sato, John S. Lyssand, Gary Geiss, Joseph M. Beechem

Publikováno v: Cancer Research Communications. 3:763-779

A deeper understanding of complex biological processes, including tumor development and immune response, requires ultra high-plex, spatial interrogation of multiple “omes”. Here we present the development and implementation of a novel spatial pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78575f0b4ed76e36cb72cb2f060aa3dd
https://doi.org/10.1158/2767-9764.crc-22-0396

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Akademický článek

Genome sequences of two diploid wild relatives of cultivated sweetpotato reveal targets for genetic improvement

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Sweetpotato is an important food security crop providing rich source of macro- and micronutrients including carbohydrates and vitamins. Here, the authors assemble of the two diploid relatives of cultivated sweetpotato and identify genes and alleles a

Externí odkaz: https://doaj.org/article/687ac8e03d8244e6bbce8b0bef8a94db

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Akademický článek

Genome Assembly and Annotation of the Medicinal Plant Calotropis gigantea, a Producer of Anticancer and Antimalarial Cardenolides

Autor: Genevieve M. Hoopes, John P. Hamilton, Jeongwoon Kim, Dongyan Zhao, Krystle Wiegert-Rininger, Emily Crisovan, C. Robin Buell

Publikováno v: G3: Genes, Genomes, Genetics, Vol 8, Iss 2, Pp 385-391 (2018)

Calotropis gigantea produces specialized secondary metabolites known as cardenolides, which have anticancer and antimalarial properties. Although transcriptomic studies have been conducted in other cardenolide-producing species, no nuclear genome ass

Externí odkaz: https://doaj.org/article/77eb9916b93f4281af4caef285aa239c

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