Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors.

Autor: Ramurthy S; HiberCell, Inc., 619 West 54th Street, New York, NY 10019, USA., Pfister KB; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, USA., Boyce RS; Vermont Biosynthetics LLC, 365 Glinnis Road, Northfield, VT 05663, USA., Brown SP; Proneurotech, 161 Oyster Point Blvd., Suite 200, South San Francisco, CA 94080, USA., Costales AQ; Chevron Oronite Company LLC, 100 Chevron Way, Richmond, CA 94801, USA., Desai MC; Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, USA., Fang E; Protein Sciences, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, USA., Levine BH; 2026 South Lincoln Avenue, Spokane, WA 99203, USA., Ng SC; 311 Preakness Court, Walnut Creek, CA 94597, USA., Nuss JM; Oppilan Pharma, Ltd., 332 Encinitas Blvd., Encinitas, CA 92024, USA., Ring DB; 2375 Cowper Street, Palo Alto, CA 94301, USA., Shafer CM; Arcus Biosciences, 3928 Point Eden Way, Hayward, CA 94545, USA., Shu W; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, USA., Subramanian S; 3305 Cydonia Ct., Dublin, CA 94568, USA., Wagman AS; Rain Therapeutics Inc., 8000 Jarvis Avenue, Suite 204, Newark, CA 94560, USA., Wang H; Takeda San Diego Inc., 10410 Science Center Dr., San Diego, CA 92121, USA., Bussiere DE; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA 94608, USA. Electronic address: dirksen.bussiere@novartis.com.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Feb 15; Vol. 30 (4), pp. 126930. Date of Electronic Publication: 2019 Dec 23.

The Co-pathogenic Target Gene CNTN1 Involved in Coronary Artery Disease and Pulmonary Arterial Hypertension Has Potential for Diagnosis of Coronary Artery Disease.

Autor: Kun Cheng¹, Qixuan Zhai¹, Jieqiong Song², Bing Liu¹ lb19840404@126.com

Publikováno v: Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi. Aug2024, Vol. 28 Issue 8, p381-392. 13p.

Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.

Autor: Wagman AS; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Boyce RS; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Brown SP; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Fang E; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Goff D; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Jansen JM; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Le VP; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Levine BH; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Ng SC; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Ni ZJ; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Nuss JM; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Pfister KB; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Ramurthy S; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Renhowe PA; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Ring DB; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Shu W; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Subramanian S; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Zhou XA; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Shafer CM; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Harrison SD; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Johnson KW; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Bussiere DE; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Oct 26; Vol. 60 (20), pp. 8482-8514. Date of Electronic Publication: 2017 Oct 10.

A prediction model of ultimate forming dimension for profile ring with outer groove in ring rolling process.

Autor: Deng, Jiadong^1,2,3,4 (AUTHOR), Wu, Rongwen^1,5 (AUTHOR), Sun, Zhongyuan^1,2 (AUTHOR), Qian, Dongsheng^2,3,4 (AUTHOR) qiands@whut.edu.cn, Zhang, Yanhua⁶ (AUTHOR)

Publikováno v: International Journal of Advanced Manufacturing Technology. Jan2024, Vol. 130 Issue 1/2, p491-510. 20p.

Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives.

Autor: Sadashiva, Maralinganadoddi Panchegowda¹, Basappa^2,3, NanjundaSwamy, Shivananju⁴, Li, Feng⁴, Manu, Kanjoormana Aryan⁴, Sengottuvelan, Murugan², Prasanna, Doddakunche Shivaramu¹, Anilkumar, Nirvanappa Chikkagundagal³, Sethi, Gautam⁴, Sugahara, Kazuyuki², Rangappa, Kanchugarakoppal Subbegowda¹ rangappaks@gmail.com

Publikováno v: BMC Chemical Biology. 2012, Vol. 12 Issue 1, p5-15. 11p. 1 Color Photograph, 1 Black and White Photograph, 3 Diagrams, 4 Charts, 6 Graphs.