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Autor:
Bart O. Roep, Erik Thorsby, Dag E. Undlien, Frank Dudbridge, Bobby P. C. Koeleman, Francesco Cucca, Benedicte A. Lie, John A. Todd, Rindert R. P. De Vries, Marius J. Giphart
Publikováno v:
GENES AND IMMUNITY, 5(5), 381-388. Nature Publishing Group
Alleles of HLA class II genes DQB1, DQA1, and DRB1 in the MHC region are major determinants of genetic predisposition to type 1 diabetes (T1D). Several alleles of each of these three loci are associated with susceptibility or protection from disease.