Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Rinat Zaynagetdinov"'
Autor:
Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTNatural killer (NK) cells emerged as a promising effector population that can be harnessed for anti-tumor therapy. In this work, we constructed NK cell engagers (NKCEs) based on NKp30-targeting single domain antibodies (sdAbs) that redirect t
Externí odkaz:
https://doaj.org/article/dab9f66e27944e228e065c4ff4d03f51
Autor:
Dong Zhang, Feng Jiang, Rinat Zaynagetdinov, Hui Huang, Vanita D. Sood, Hong Wang, Xinyan Zhao, Molly H. Jenkins, Qingyong Ji, Youbin Wang, David P. Nannemann, Djordje Musil, John Wesolowski, Andrea Paoletti, Tin Bartholomew, Melissa G. Derner, Qi An, Christel Iffland, Joern-Peter Halle
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
T cell immunoglobulin and mucin domain-3 (TIM-3) is an immune checkpoint that regulates normal immune responses but can be exploited by tumor cells to evade immune surveillance. TIM-3 is primarily expressed on immune cells, particularly on dysfunctio
Externí odkaz:
https://doaj.org/article/f2420cb2a82040deb84b2167b543e3fe
Autor:
Allyson G. McLoed, Taylor P. Sherrill, Dong-Sheng Cheng, Wei Han, Jamie A. Saxon, Linda A. Gleaves, Pingsheng Wu, Vasiliy V. Polosukhin, Michael Karin, Fiona E. Yull, Georgios T. Stathopoulos, Vassilis Georgoulias, Rinat Zaynagetdinov, Timothy S. Blackwell
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 120-132 (2016)
Although epithelial NF-κB signaling is important for lung carcinogenesis, NF-κB inhibitors are ineffective for cancer treatment. To explain this paradox, we studied mice with genetic deletion of IKKβ in myeloid cells and found enhanced tumorigenes
Externí odkaz:
https://doaj.org/article/f58ff440a1344da388aafc8cddd5f332
Autor:
Megha Talati, Haitham Mutlak, Kirk B. Lane, Wei Han, Anna Hemnes, Outi Mutlak, Tom Blackwell, Rinat Zaynagetdinov, Timothy S. Blackwell, James West
Publikováno v:
Diseases, Vol 2, Iss 2, Pp 148-167 (2014)
Aim: The present study investigates the role of NF-κB in Bmpr2-related pulmonary hypertension (PH) using a murine model of PH with inducible overexpression of a cytoplasmic tail Bmpr2 mutation. Methods and Results: Electrophoretic mobility shift ass
Externí odkaz:
https://doaj.org/article/df81727870de4bbc8cebe6c5402aeeca
Autor:
Sergey Ryzhov, Sergey V. Novitskiy, David P. Carbone, Italo Biaggioni, Rinat Zaynagetdinov, Anna E. Goldstein, Mikhail M. Dikov, Igor Feoktistov
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 9, Pp 987-995 (2008)
Recent studies suggest that tumor-infiltrating immune cells can benefit the tumor by producing factors that promote angiogenesis and suppress immunity. Because the tumor microenvironment is characterized by high adenosine levels, we hypothesized that
Externí odkaz:
https://doaj.org/article/e2feef913f174c879e6cc380afe865d0
Autor:
Megha Talati, James West, Rinat Zaynagetdinov, Charles C Hong, Wei Han, Tom Blackwell, Linda Robinson, Timothy S Blackwell, Kirk Lane
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94119 (2014)
Pulmonary arterial hypertension (PAH) is a disease of progressively increasing pulmonary vascular resistance, associated with mutations of the type 2 receptor for the BMP pathway, BMPR2. The canonical signaling pathway for BMPR2 is through the SMAD f
Externí odkaz:
https://doaj.org/article/08156025a98f4e33bd178f47388b0811
Autor:
Katja Klausz, Lukas Pekar, Ammelie Svea Boje, Carina Lynn Gehlert, Steffen Krohn, Tushar Gupta, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Britta Lipinski, Lars Toleikis, Sven Poetzsch, Brian Rabinovich, Matthias Peipp, Stefan Zielonka
Publikováno v:
The Journal of Immunology. 209:1724-1735
In this work, we have generated novel Fc-comprising NK cell engagers (NKCEs) that bridge human NKp30 on NK cells to human epidermal growth factor receptor (EGFR) on tumor cells. Camelid-derived VHH single-domain Abs specific for human NKp30 and a hum
Autor:
Timothy S. Blackwell, Georgios T. Stathopoulos, Fiona E. Yull, Barbara Fingleton, R. Stokes Peebles, Daniel Dulek, Linda Connelly, Arun C. Habermann, Jamie A. Saxon, Allyson G. McLoed, Linda A. Gleaves, Taylor P. Sherrill, Rinat Zaynagetdinov
Figure S2. Deficiency in IL-5 does not affect infiltration of lungs with T and B lymphocytes and NK cells during initial stages of metastatic load of LLC cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f629ace44083a1b9a05698a550cda3b
https://doi.org/10.1158/0008-5472.22407179.v1
https://doi.org/10.1158/0008-5472.22407179.v1
Autor:
Rinat Zaynagetdinov, Kai Schiemann, Kalyan Nallaparaju, Natalya Belousova, Armine Matevossian, Zhouxiang Chen, Giorgio Kradjian, Meghana Pandya, Nemisha Dawra, Eva-Maria Krauel, Elissaveta Petrova, Oliver Poeschke, David Fischer, Marc Lecomte, Andree Blaukat, Bayard Huck, Jacques Moisan
Publikováno v:
Cancer Research. 82:3499-3499
Under physiological conditions, the extracellular concentrations of adenosine are low, however, levels dramatically increase under metabolically stressful conditions, including inflammation and cancer. The regulatory functions of adenosine are mediat
Autor:
Molly H. Jenkins, Vanita D. Sood, Feng Jiang, Christel Iffland, An Qi, Hui Huang, Xinyan Zhao, Joern-Peter Halle, Qingyong Ji, Hong Wang, Melissa G Derner, Dong Zhang, John S. Wesolowski, Djordje Musil, Andrea Paoletti, Rinat Zaynagetdinov, Tin Bartholomew, D.P. Nannemann, Youbin Wang
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Oncoimmunology
Oncoimmunology
T cell immunoglobulin and mucin domain-3 (TIM-3) is an immune checkpoint that regulates normal immune responses but can be exploited by tumor cells to evade immune surveillance. TIM-3 is primarily expressed on immune cells, particularly on dysfunctio