Výsledky vyhledávání - "Rinat Tabakman"

Akademický článek

DSP107 combines inhibition of CD47/SIRPα axis with activation of 4-1BB to trigger anticancer immunity

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)

Abstract Background Treatment of Diffuse Large B Cell Lymphoma (DLBCL) patients with rituximab and the CHOP treatment regimen is associated with frequent intrinsic and acquired resistance. However, treatment with a CD47 monoclonal antibody in combina

Externí odkaz: https://doaj.org/article/88f427a2882642b7b2f32986f378f0e2

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Akademický článek

AGI-134: a fully synthetic α-Gal glycolipid that converts tumors into in situ autologous vaccines, induces anti-tumor immunity and is synergistic with an anti-PD-1 antibody in mouse melanoma models

Autor: Stephen M. Shaw, Jenny Middleton, Kim Wigglesworth, Amber Charlemagne, Oliver Schulz, Melanie S. Glossop, Giles F. Whalen, Robert Old, Mike Westby, Chris Pickford, Rinat Tabakman, Irit Carmi-Levy, Abi Vainstein, Ella Sorani, Arik A. Zur, Sascha A. Kristian

Publikováno v: Cancer Cell International, Vol 19, Iss 1, Pp 1-19 (2019)

Abstract Background Treatments that generate T cell-mediated immunity to a patient’s unique neoantigens are the current holy grail of cancer immunotherapy. In particular, treatments that do not require cumbersome and individualized ex vivo processi

Externí odkaz: https://doaj.org/article/440a5a0ba0874d0aa71454cddd24f71c

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790 DSP502 — A novel approach for targeting TIGIT and PD1 pathways for cancer immunotherapy

Autor: Matthew P. Weber, Elina Zorde-Khvalevsky, Amnon Peled, Adam Foley-Comer, Ami Tamir, Ayelet Chajut, Lucy Ganthous, Alexandra Aronin, Rinat Tabakman, Shirley Greenwald, Jasmine Avichzer, Roy Kahn, Mark L. Tykocinski, Iris Pecker, Liat Ben Gigi Tamir, Michal Michal Elhalel Dranitzki

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundTIGIT, an inhibitory immune checkpoint, is a target of interest for immuno-oncology combination therapies. TIGIT is part of a complex molecular network containing four receptors (DNAM1, TIGIT, PVRIG and CD96) and two ligands (PVR and PVRL2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace81f6d30f90242de6e37a20b6a0608
https://doaj.org/article/9d1d813fb3514e5b91af359675727c2a

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Phase 1 dose escalation study of DSP107, a first-in-class CD47 and 4-1BB targeting multifunctional immune-recruitment protein, in patients with advanced solid tumors

Autor: Jason J. Luke, Anwaar Saeed, Babar Bashir, Yaffa Shwartz, Rinat Tabakman, Adam Foley-Comer, Antonio Jimeno

Publikováno v: Journal of Clinical Oncology. 40:2647-2647

2647 Background: DSP107 is a bi-functional, trimeric, fusion protein composed of sequences from the extracellular domain of SIRPα and 4-1BBL. The SIRPα arm targets CD47 overexpressed on tumor cells, blocking the “don’t eat me” checkpoint and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91792f2a3ce9440d0556256a58257fe6
https://doi.org/10.1200/jco.2022.40.16_suppl.2647

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Akademický článek

BL-7010 demonstrates specific binding to gliadin and reduces gluten-associated pathology in a chronic mouse model of gliadin sensitivity.

Autor: Justin L McCarville, Yotam Nisemblat, Heather J Galipeau, Jennifer Jury, Rinat Tabakman, Ad Cohen, Esmira Naftali, Bela Neiman, Efrat Halbfinger, Joseph A Murray, Arivarasu N Anbazhagan, Pradeep K Dudeja, Alexander Varvak, Jean-Christophe Leroux, Elena F Verdu

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e109972 (2014)

Celiac disease (CD) is an autoimmune disorder in individuals that carry DQ2 or DQ8 MHC class II haplotypes, triggered by the ingestion of gluten. There is no current treatment other than a gluten-free diet (GFD). We have previously shown that the BL-

Externí odkaz: https://doaj.org/article/7087f82fe61d4343ab2aa2478ca871df

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AGI-134: a fully synthetic α-Gal glycolipid that converts tumors into in situ autologous vaccines, induces anti-tumor immunity and is synergistic with an anti-PD-1 antibody in mouse melanoma models

Autor: Abi Vainstein, Arik A. Zur, Ella Sorani, Giles F. Whalen, Jenny Middleton, Chris Pickford, Melanie S. Glossop, Robert Old, Oliver Schulz, Sascha A. Kristian, Irit Carmi-Levy, Amber Charlemagne, Mike Westby, Rinat Tabakman, Kim Wigglesworth, Stephen M. Shaw

Publikováno v: Cancer Cell International, Vol 19, Iss 1, Pp 1-19 (2019)
Cancer Cell International

BackgroundTreatments that generate T cell-mediated immunity to a patient’s unique neoantigens are the current holy grail of cancer immunotherapy. In particular, treatments that do not require cumbersome and individualized ex vivo processing or manu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a18846f7bb9b2696a1417608b07aba
https://doi.org/10.1186/s12935-019-1059-8

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Neuroprotective effects of nimodipine and nifedipine in the NGF‐differentiated PC12 cells exposed to oxygen‐glucose deprivation or trophic withdrawal

Autor: Rinat Tabakman, Philip Lazarovici, Hadar Arien-Zakay, Rami Yaka, Shimon Lecht, Elena Rotfeld, Henry Matzner, Peter I. Lelkes

Publikováno v: International Journal of Developmental Neuroscience. 30:465-469

The goal of this study was to compare the neuroprotective properties of the l -type Ca2+ channel blockers, nimodipine and nifedipine, using nerve growth factor (NGF)-differentiated PC12 neuronal cultures exposed to oxygen-glucose deprivation (OGD) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9add8049af2613151ec8c43b0113b012
https://doi.org/10.1016/j.ijdevneu.2012.05.007

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The induction of tuftelin expression in PC12 cell line during hypoxia and NGF-induced differentiation

Autor: Anat Blumenfeld, Eli Rosenfeld, Rinat Tabakman, Philip Lazarovici, Shimon Lecht, Boaz Shay, Dekel Shilo, Yoav Leiser, Dan Deutsch, Nechama Silverstein, Amir Haze

Publikováno v: Journal of Cellular Physiology. 226:165-172

The tuftelin protein isoforms undergo post-translation modifications, and are ubiquitously expressed in various tissues in embryos, adults, and tumors. Developmental and pathological studies suggested an apparent correlation between oxygen deprivatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dfb515312f39ed14a85ff808ba09cc
https://doi.org/10.1002/jcp.22318

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Intratumoral administration of the alpha-Gal glycolipid AGI-134 to induce tumor regression in a mouse model of melanoma

Autor: Jenny Middleton, Ella Sorani, Abi Vainstein Haras, Rinat Tabakman, Kim Wigglesworth, Sascha A. Kristian, Irit Carmi Levy, Stephen M. Shaw

Publikováno v: Journal of Clinical Oncology. 36:68-68

68 Background: AGI-134 is a fully synthetic alpha-Gal glycolipid for intratumoral (i.t.) treatment of solid tumors to induce a patient-specific anti-tumor immune response. AGI-134 recruits pre-existing anti-Gal antibodies to the injected lesion, lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f464f0aa1f3cf252be6ca540947a44aa
https://doi.org/10.1200/jco.2018.36.5_suppl.68

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