Stemodane Diterpenes and Diterpenoids: Isolation, Structure Elucidation, Biogenesis, Biosynthesis, Biological Activity, Biotransformations, Metabolites and Derivatives Biological Activity, Rearrangements

Autor: Francesca Leonelli, Luisa Maria Migneco, Alessio Valletta, Rinaldo Marini Bettolo

Publikováno v: Molecules, Vol 26, Iss 9, p 2761 (2021)

The scientific activity carried out over forty-five years on stemodane diterpenes and diterpenoids structure elucidation, biogenesis, biosynthesis, biological activity and biotransformations was reviewed.

Externí odkaz: https://doaj.org/article/0fdea77f1d914f1ab9ce5aeebce89ff7

Bicyclo[2.2.2]octane analogues of patchouli alcohol by Sakurai reaction and Nagata cyclization. Synthesis and olfactory properties of novel isopropyl derivatives

Autor: Angela La Bella, Ilaria Popolla, Marco Felici, Francesca Leonelli, Francesca Ceccacci, Luigi Filocamo, Luisa Maria Migneco, Rinaldo Marini Bettolo

Publikováno v: ARKIVOC, Vol 2008, Iss 3, Pp 80-90 (2007)

Externí odkaz: https://doaj.org/article/fda7b33bf7114ae6ac2b4e50e73f92a5

(+)-Podocarpic Acid as Chiral Template in the Synthesis of Aphidicolane, Stemodane and Stemarane Diterpenoids †

Autor: Angela La Bella, Francesca Leonelli, Luisa Maria Migneco, Rinaldo Marini Bettolo

Publikováno v: Molecules, Vol 21, Iss 9, p 1197 (2016)

In this review the synthetic work in the field of aphidicolane, stemodane and stemarane diterpenoids, in which readily available (+)-podocarpic acid (4) was used as chiral template for the construction of their polycyclic structures, is described as

Externí odkaz: https://doaj.org/article/64325944da1a4dc38f543d416ec224c1

Unexpected Racemization in the Course of the Acetalization of (+)-(

Autor: Francesca, Leonelli, Irene, Piergentili, Giulio, Lucarelli, Luisa Maria, Migneco, Rinaldo, Marini Bettolo

Publikováno v: International Journal of Molecular Sciences

(+)-(S) and (−)-(R)-5-methyl-Wieland-Miescher ketone (+)-1 and (−)-1, are important synthons in the diastereo and enantioselective syntheses of biological and/or pharmacological interesting compounds. A key step in these syntheses is the chemosel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::712ee055149bdf846d325cec1e8b1d02
https://pubmed.ncbi.nlm.nih.gov/31817544

Targeting Serotonin 2A and Adrenergic α1 Receptors for Ocular Antihypertensive Agents: Discovery of 3,4-Dihydropyrazino[1,2-b]indazol-1(2H)-one Derivatives

Autor: M. A. Loreto, Marco Vitiello, Beatrice Garrone, Martina Miceli, Maria Alessandra Alisi, Magaro' Gabriele, Rinaldo Marini Bettolo, Emanuela Masini, Luisa Maria Migneco, Guido Furlotti, Francesca Leonelli, Nicola Cazzolla, Giorgina Mangano, Tecla Gasperi, Francesca Ceccacci, Angela La Bella

Publikováno v: ChemMedChem
13 (2018): 1597–1607. doi:10.1002/cmdc.201800199
info:cnr-pdr/source/autori:Furlotti G. (a); Alisi M. A. (a); Cazzolla N. (a); Ceccacci F. (b,f); Garrone B. (a); Gasperi T. (d); La Bella A. (b); Leonelli F. (b,c); Loreto M. A. (b); Magarò G. (a); Mangano G. (a); Marini Bettolo R. (b); Masini E. (e); Miceli M. (d); Migneco L. M. (b); Vitiello M. (a)/titolo:Targeting Serotonin 2A and Adrenergic alfa1 Receptors for Ocular Antihypertensive Agents: Discovery of 3,4-Dihydropyrazino[1,2-b]indazol-1(2H)-one Derivatives/doi:10.1002%2Fcmdc.201800199/rivista:ChemMedChem (Print)/anno:2018/pagina_da:1597/pagina_a:1607/intervallo_pagine:1597–1607/volume:13

Glaucoma affects millions of people worldwide, causing optic nerve damage and blindness. The elevation of the intraocular pressure (IOP) is the main risk factor associated with this pathology, and nowadays, the key therapeutic target of the existing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612c3db8946e01f1e85f720922748c76
https://hdl.handle.net/11590/336581