Phenotypic and genetic characterization of MERS coronaviruses from Africa to understand their zoonotic potential

Autor: Elias Walelign, Malik Peiris, Huibin Lv, Ziqi Zhou, Ouafaa Fassi-Fihri, Leo L.M. Poon, Harry Oyas, John M. Nicholls, Rinah Wanglia, Jincun Zhao, Sophie Von Dobschuetz, Yanqun Wang, Ranawaka A.P.M. Perera, Michael C. W. Chan, Eve Miguel, Obadiah Njagi, Ray T.Y. So, Ihab El Masry, Kenrie P Y Hui, Takele Abayneh, Amadou Trarore, Weiwen Liang, Daniel K.W. Chu, Esayas Gelaye, Wilson Kuria, Véronique Chevalier, Chris Ka Pun Mok, Wantanee Kalpravidh

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (25), pp.e2103984118. ⟨10.1073/pnas.2103984118/-/DCSupplemental.⟩
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (25), pp.e2103984118. ⟨10.1073/pnas.2103984118/-/DCSupplemental⟩

Significance The absence of zoonotic MERS-CoV in Africa in spite of an abundance of MERS-CoV–infected dromedaries has remained an enigma. We demonstrate that geographically and genetically distinct viruses from Africa have low replication competenc

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