Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rina Sugimoto"'
Publikováno v:
Biochemical and Biophysical Research Communications. 545:14-19
Paneth cells and Lgr5+ intestinal stem cells (Lgr5+ ISCs) constitute the stem cell niche and maintain small intestinal epithelial integrity by recognizing various niche factors derived from subepithelial cells and external antigens. Although it has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254795c5af7a775cec0af75dd3e2240a
https://doi.org/10.1016/j.bbrc.2021.01.050
https://doi.org/10.1016/j.bbrc.2021.01.050
Autor:
Mariko Kamioka, Yoshiyuki Goto, Kiminori Nakamura, Yuki Yokoi, Rina Sugimoto, Shuya Ohira, Yosuke Kurashima, Shingo Umemoto, Shintaro Sato, Jun Kunisawa, Yu Takahashi, Steven E. Domino, Jean-Christophe Renauld, Susumu Nakae, Yoichiro Iwakura, Peter B. Ernst, Tokiyoshi Ayabe, Hiroshi Kiyono
Publikováno v:
Proceedings of the National Academy of Sciences. 119
SignificancePaneth cells produce granules containing antimicrobial peptides, such as α-defensin for host defense. Examination of the production and utilization of fucosyltransferase 2 (Fut2) by Paneth cells revealed two distinct subsets: Fut2+Paneth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6578bb991c74718f911cb8dd5b5da246
https://doi.org/10.1073/pnas.2115230119
https://doi.org/10.1073/pnas.2115230119
Autor:
Mariko, Kamioka, Yoshiyuki, Goto, Kiminori, Nakamura, Yuki, Yokoi, Rina, Sugimoto, Shuya, Ohira, Yosuke, Kurashima, Shingo, Umemoto, Shintaro, Sato, Jun, Kunisawa, Yu, Takahashi, Steven E, Domino, Jean-Christophe, Renauld, Susumu, Nakae, Yoichiro, Iwakura, Peter B, Ernst, Tokiyoshi, Ayabe, Hiroshi, Kiyono
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Paneth cells produce granules containing antimicrobial peptides, such as α-defensin for host defense. Examination of the production and utilization of fucosyltransferase 2 (Fut2) by Paneth cells revealed two distinct subsets: Fut2+ Pane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ff9da6778b5f28af1016d32f8bdffe2
https://pubmed.ncbi.nlm.nih.gov/35027453
https://pubmed.ncbi.nlm.nih.gov/35027453
Autor:
Hiroshi Mori, Hiroyuki Ohigashi, Ken Kurokawa, Satomi Matsuoka, Ko Ebata, Shuichiro Takahashi, Rina Hiramine, Tomohiro Yamakawa, Emi Yokoyama, Yoshitoshi Ogura, Tokiyoshi Ayabe, Rina Sugimoto, Takahide Ara, Tetsuya Hayashi, Kiminori Nakamura, Tomoyasu Aizawa, Reiki Ogasawara, Yuki Yokoi, Takanori Teshima, Eiko Hayase, Daigo Hashimoto, Kazuma Tomizuka, Takeshi Kondo, Clara Noizat
Publikováno v:
The Journal of Experimental Medicine
Hayase et al. show that R-Spondin1 stimulates intestinal stem cells to differentiate to Paneth cells and enhances luminal secretion of α-defensins. Administration of R-Spondin1 or recombinant α-defensin prevents dysbiosis mediated by graft-versus-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e2bad19ff7dc01fddc25dd962e99d0
https://doi.org/10.1084/jem.20170418
https://doi.org/10.1084/jem.20170418
Autor:
Mariko Kamioka, Yoshiyuki Goto, Kiminori Nakamura, Yuki Yokoi, Rina Sugimoto, Yosuke Kurashima, Shingo Umemoto, Shintaro Sato, Jun Kunisawa, Yu Takahashi, Domino, Steven E., Renauld, Jean-Christophe, Susumu Nakae, Yoichiro Iwakura, Ernst, Peter B., Tokiyoshi Ayabe, Hiroshi Kiyono
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 1/18/2022, Vol. 119 Issue 3, p1-10, 10p
Autor:
Yuki Yokoi, Kiminori Nakamura, Rina Sugimoto, Mani Kikuchi, Akiko Takakuwa, Tokiyoshi Ayabe, Shuya Ohira
Publikováno v:
Nutrients, Vol 11, Iss 11, p 2817 (2019)
Nutrients
Volume 11
Issue 11
Nutrients
Volume 11
Issue 11
The intestine not only plays a role in fundamental processes in digestion and nutrient absorption, but it also has a role in eliminating ingested pathogenic bacteria and viruses. Paneth cells, which reside at the base of small intestinal crypts, secr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370d7c8bd516cae147754ea2031686c0
https://www.mdpi.com/2072-6643/11/11/2817
https://www.mdpi.com/2072-6643/11/11/2817
Autor:
Rina Sugimoto, Yuki Yokoi, Tokiyoshi Ayabe, Kiminori Nakamura, Yu Shimizu, Tsukasa Yoneda, Mani Kikuchi
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Paneth cells at the base of small intestinal crypts secrete granules containing α-defensins in response to bacteria and maintain the intestinal environment by clearing enteric pathogens and regulating the composition of the intestinal microbiota. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d99e438d941842af6e88b0ad80e20c
https://doi.org/10.1038/s41598-019-39610-7
https://doi.org/10.1038/s41598-019-39610-7
Autor:
Aki Yoshii, Shunta Nakamura, Ryuga Shinozaki, Yu Shimizu, Shuya Ohira, Mani Kikuchi, Yuki Yokoi, Rina Sugimoto, Kiminori Nakamura, Tokiyoshi Ayabe
Publikováno v:
Life Science Alliance
This study provides novel insight into Crohn’s disease where α-defensin misfolding resulting from excessive ER stress in Paneth cells induces dysbiosis and disease progression.
Crohn’s disease (CD) is an intractable inflammatory bowel disea
Crohn’s disease (CD) is an intractable inflammatory bowel disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cce16702f3d1c12325d8852d64fd964
https://doi.org/10.26508/lsa.201900592
https://doi.org/10.26508/lsa.201900592
Autor:
Takahiro Yamamoto, Tokiyoshi Ayabe, Masaya Shimada, Kiminori Nakamura, Rina Sugimoto, Kan Yaguchi, Ryota Uehara
Publikováno v:
Biochemical and biophysical research communications. 504(1)
Near-haploidy is observed in certain cancer types, but ploidy-dependent alterations in gene regulation in the haploid state remain elusive. Here, by comparative transcriptome analysis between human isogenic haploid and diploid cell lines, we found lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3a22017c066db628b59423eea2a4e9
https://pubmed.ncbi.nlm.nih.gov/30193733
https://pubmed.ncbi.nlm.nih.gov/30193733