Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Rina Plattner"'
Autor:
Hannah G. Daniels, Breanna G. Knicely, Anna Kristin Miller, Ana Thompson, Rina Plattner, Eva M. Goellner
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The DNA mismatch repair (MMR) pathway and its regulation are critical for genomic stability. Mismatch repair (MMR) follows replication and repairs misincorporated bases and small insertions or deletions that are not recognized and removed by the proo
Externí odkaz:
https://doaj.org/article/bb28fe98fae9483a8b00feba2402e5c5
Autor:
Rakshamani Tripathi, Zulong Liu, Aditi Jain, Anastasia Lyon, Christina Meeks, Dana Richards, Jinpeng Liu, Daheng He, Chi Wang, Marika Nespi, Andrey Rymar, Peng Wang, Melissa Wilson, Rina Plattner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Resistance to BRAF/MEK inhibitors is a major impediment to long-term survival for patients with BRAF-mutant melanomas. Here, the authors show that ABL kinases drive resistance by promoting MEK/ERK reactivation and the FDA-approved ABL kinase inhibito
Externí odkaz:
https://doaj.org/article/7126349dcc164a17b73b14d99a4c497c
Autor:
Rakshamani Tripathi, Rina Plattner
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 4 (2018)
Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases. We reported that ABL kinases induce cathepsin secretion and subsequent metas
Externí odkaz:
https://doaj.org/article/8f88221ae34a499b8f115dd9be4b094f
Autor:
Huajun Zhao, Fu Ou-Yang, I-Fen Chen, Ming-Feng Hou, Shyng-Shiou F. Yuan, Hsueh-Ling Chang, Yi-Chen Lee, Rina Plattner, Susan E. Waltz, Shuk-Mei Ho, Jonathan Sims, Shao-Chun Wang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 3, Pp 214-223 (2010)
Targeting the estrogen receptor is an important strategy in breast cancer therapy. However, although inhibiting estrogen receptor function with specific estrogen receptor modulators can achieve a primary response in cancer patients, intrinsic or subs
Externí odkaz:
https://doaj.org/article/a9b71fb5b83c49fba0ff1a398cb93927
Autor:
Jonathan T Sims, Sourik S Ganguly, Holly Bennett, J Woodrow Friend, Jessica Tepe, Rina Plattner
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55509 (2013)
Despite advances in cancer detection and prevention, a diagnosis of metastatic disease remains a death sentence due to the fact that many cancers are either resistant to chemotherapy (conventional or targeted) or develop resistance during treatment,
Externí odkaz:
https://doaj.org/article/37064d72b56841e49d546a9012964f89
Autor:
Rina Plattner, Divyamani Srinivasan
Supplementary Figures 1-3 from Activation of Abl Tyrosine Kinases Promotes Invasion of Aggressive Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be87081e5ded680787c94452728eb79
https://doi.org/10.1158/0008-5472.22364853.v1
https://doi.org/10.1158/0008-5472.22364853.v1
Autor:
Rina Plattner, Divyamani Srinivasan
The Abl family of nonreceptor tyrosine kinases consists of two related proteins, c-Abl and Abl-related gene (Arg). Activated forms of the Abl kinases (BCR-Abl, Tel-Abl, and Tel-Arg) induce the development of human leukemia; it is not known, however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e5efeacc59d9d44c7d4e83fdc6cda6
https://doi.org/10.1158/0008-5472.c.6494397
https://doi.org/10.1158/0008-5472.c.6494397
Autor:
Daheng He, Marika Nespi, Zulong Liu, Christina Meeks, Anastasia Lyon, Jinpeng Liu, Andrey Rymar, Peng Wang, Chi Wang, Rina Plattner, Melissa Wilson, Aditi Jain, Rakshamani Tripathi, Dana Richards
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Metastatic melanoma remains an incurable disease for many patients due to the limited success of targeted and immunotherapies. BRAF and MEK inhibitors reduce metastatic burden for patients with melanomas harboring BRAF mutations; however, most eventu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ebf1770192e74b479c773749c757d4
http://link.springer.com/article/10.1038/s41467-020-19075-3
http://link.springer.com/article/10.1038/s41467-020-19075-3
Autor:
Anastasia Lyon, Rakshamani Tripathi, Christina Meeks, Daheng He, Yuanyuan Wu, Jinpeng Liu, Chi Wang, Jing Chen, Haining Zhu, Sujata Mukherjee, Saptadwipa Ganguly, Rina Plattner
Publikováno v:
Cancers
Volume 15
Issue 3
Pages: 954
Volume 15
Issue 3
Pages: 954
Melanomas harboring NRAS mutations are a particularly aggressive and deadly subtype. If patients cannot tolerate or the melanomas are insensitive to immune checkpoint blockade, there are no effective 2nd-line treatment options. Drugs targeting the RA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a270d48e85048a0bd54613a3bec94b
https://doi.org/10.3390/cancers15030954
https://doi.org/10.3390/cancers15030954
Autor:
Kristen S. Hill, Sally R. Ellingson, Jill M. Kolesar, Rina Plattner, Erin E Schuler, Anthony McDowell, J. Robert McCorkle
Publikováno v:
Cancers, Vol 13, Iss 1885, p 1885 (2021)
Cancers; Volume 13; Issue 8; Pages: 1885
Cancers
Cancers; Volume 13; Issue 8; Pages: 1885
Cancers
Simple Summary The antimalarial drug artesunate also has anticancer activity. Based on what is known about how artesunate works in malaria, we hypothesized that the kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b82637867cd345fd304e7050cebf52
https://www.mdpi.com/2072-6694/13/8/1885
https://www.mdpi.com/2072-6694/13/8/1885