Výsledky vyhledávání - "Rina J. Kara"

Cyclin A2 Induces Cardiac Regeneration After Myocardial Infarction Through Cytokinesis of Adult Cardiomyocytes

Autor: Rina J. Kara, Scott Shapiro, Romit Bhattacharya, Richard Cheng, Gabriela Guzmán-Martínez, Javier Sanz, Yoshiaki Kawase, Hina W. Chaudhry, Mario J. Garcia, Amaresh K. Ranjan

Publikováno v: Science Translational Medicine. 6

Cyclin A2 (Ccna2), normally silenced after birth in the mammalian heart, can induce cardiac repair in small-animal models of myocardial infarction. We report that delivery of the Ccna2 gene to infarcted porcine hearts invokes a regenerative response.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29b2cf82dc608bbae9e856288110779
https://doi.org/10.1126/scitranslmed.3007668

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A Mouse Model for Fetal Maternal Stem Cell Transfer during Ischemic Cardiac Injury

Autor: Rina J. Kara, B S Perry Altman, Hina W. Chaudhry, Iwao Matsunaga, Omar Tanweer, Paola Bolli

Fetal cells enter the maternal circulation during pregnancies and can persist in blood and tissues for decades, creating a state of physiologic microchimerism. Microchimerism refers to acquisition of cells from another individual and can be due to bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5af2130cf3f53c406244467d9e2a9a
https://europepmc.org/articles/PMC3419501/

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Fetal cells traffic to injured maternal myocardium and undergo cardiac differentiation

Autor: Austin Nakano, Paola Bolli, Ioannis Karakikes, Perry Altman, Iwao Matsunaga, Neil S. Shachter, Hina W. Chaudhry, Rina J. Kara, Vesna Najfeld, Joseph Tripodi, Omar Tanweer

Publikováno v: Circulation research. 110(1)

Rationale: Fetal cells enter the maternal circulation during pregnancy and may persist in maternal tissue for decades as microchimeras. Objective: Based on clinical observations of peripartum cardiomyopathy patients and the high rate of recovery they

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96b7d8ea455c014163c22308d1f14cb
https://pubmed.ncbi.nlm.nih.gov/26541683

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Engineered cardiac tissues for in vitro assessment of contractile function and repair mechanisms

Autor: Rina J. Kara, Timothy P. Martens, Kevin D. Costa, Do Eun Kim, Silviu Itescu, Hina W. Chaudhry, Eun Jung Lee

Publikováno v: EMBC

For efficiently assessing the potential for grafted cells to repair infarcted myocardium, a simplified surrogate heart muscle system would offer numerous advantages. Using neonatal rat cardiac myocytes in a collagen matrix, we created thin cylindrica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f5bfe3ccb07a1f9fad76eeb8da252d
https://pubmed.ncbi.nlm.nih.gov/17946863

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Abstract 854: Homing of Fetal Stem Cells to Damaged Maternal Hearts: A Potential Mechanism for Cardiac Repair in Peripartum Cardiomyopathy

Autor: Rina J Kara, Iwao Matsunaga, Themy F Dumlao, Omar Tanweer, Neil S Shachter, Yoshifumi Naka, Hina W Chaudhry

Publikováno v: Circulation. 116

Fetal cells enter the maternal circulation during all pregnancies. They may persist in maternal blood and tissues for decades, creating a state of physiologic microchimerism. We hypothesize that fetal stem cells may be associated with a maternal resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::308a44381309236c309697de77698bf6
https://doi.org/10.1161/circ.116.suppl_16.ii_166-b

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