Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rina Baba"'
Autor:
Tetsuaki Hiyoshi, Fuqiang Zhao, Rina Baba, Takeshi Hirakawa, Ryosuke Kuboki, Kazunori Suzuki, Yoshiro Tomimatsu, Patricio O’Donnell, Steve Han, Neta Zach, Masato Nakashima
Publikováno v:
Skeletal Muscle, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Background The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle inflammation and degeneration. Therefore, the restoration of functional dystrophin levels is a fundamental approach for
Externí odkaz:
https://doaj.org/article/37c9543e3555496fbea14e74b74662d0
Autor:
Li Zhang, Genay Pilarowski, Emilio Merlo Pich, Atsushi Nakatani, John Dunlop, Rina Baba, Satoru Matsuda, Masaki Daini, Yasushi Hattori, Shigemitsu Matsumoto, Mitsuhiro Ito, Haruhide Kimura, Hans Tomas Bjornsson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 779-791 (2021)
Kabuki syndrome (KS) is a rare cause of intellectual disability primarily caused by loss-of-function mutations in lysine-specific methyltransferase 2D (KMT2D), which normally adds methyl marks to lysine 4 on histone 3. Previous studies have shown tha
Externí odkaz:
https://doaj.org/article/6bb431629e2043e29d57edb98e0cfd0f
Autor:
Misawa Niki Ishii, Masato Nakashima, Hidenori Kamiguchi, Neta Zach, Ryosuke Kuboki, Rina Baba, Takeshi Hirakawa, Kazunori Suzuki, Maria Quinton
Publikováno v:
Neuromuscular Disorders. 33:302-308
Autor:
Rina Baba, Satoru Matsuda, Ryota Maeda, Koji Murakami, Yukiko Yamamoto, Atsushi Nakatani, Haruhide Kimura
Publikováno v:
ACS Chemical Neuroscience. 13:313-321
Inhibition of lysine-specific demethylase 1 (LSD1) enzyme activity is a promising approach to treat diseases associated with epigenetic dysregulation, such as neurodevelopmental disorders. However, this concept has not been fully validated because ge
Autor:
David Alagille, Satoru Matsuda, Rina Baba, Gilles Tamagnan, Thomas J. Morley, Yasushi Hattori, Tatsuki Koike, Caroline Papin, Cristian Constantinescu, Alexandra Gouasmat, Vincent M. Carroll, Shinji Iwasaki, Kouta Matsumiya
Publikováno v:
Journal of Medicinal Chemistry. 64:3780-3793
Dysregulation of histone H3 lysine 4 (H3K4) methylation is implicated in the pathogenesis of neurodevelopmental disorders. Lysine-specific demethylase 1 (LSD1) determines the methylation status of H3K4 through flavin adenine dinucleotide (FAD)-mediat
Autor:
Yasushi Hattori, Shigemitsu Matsumoto, Shinji Morimoto, Masaki Daini, Masashi Toyofuku, Satoru Matsuda, Rina Baba, Koji Murakami, Misa Iwatani, Hideyuki Oki, Shinji Iwasaki, Kouta Matsumiya, Yusuke Tominari, Haruhide Kimura, Mitsuhiro Ito
Publikováno v:
European journal of medicinal chemistry. 239
Lysine-specific demethylase 1 (LSD1) is an enzyme that demethylates methylated histone H3 lysine 4 (H3K4). Inhibition of LSD1 enzyme activity could increase H3K4 methylation levels and treat diseases associated with epigenetic dysregulation. However,
Autor:
Shigeru Igaki, Ryosuke Hibino, Ken Tsuchida, Shinji Iwasaki, Satoru Matsuda, Ryujiro Hara, Hiroko Kamada, Masashi Toyofuku, Haruhide Kimura, Misa Iwatani, Rina Baba, Mitsuhiro Ito, Kota Matsumiya, Hideyuki Oki, Yusuke Kamada, Takeshi Hirakawa, Shinji Morimoto
Publikováno v:
Neuropsychopharmacology
Dysregulation of histone H3 lysine 4 (H3K4) methylation has been implicated in the pathogenesis of several neurodevelopmental disorders. Targeting lysine-specific demethylase 1 (LSD1), an H3K4 demethylase, is therefore a promising approach to treat t
Autor:
Ryuji Yamada, Mitsuhiro Ito, Hideyuki Oki, Yasushi Hattori, Yuuichi Arakawa, Matsumoto Shigemitsu, Satoru Matsuda, Atsushi Nakatani, Masaki Daini, Shigeru Igaki, Noriko Suzuki, Haruhide Kimura, Tatsuya Ando, Rina Baba
Publikováno v:
Science Advances
LSD1 inhibitor TAK-418 could be a therapeutic option for neurodevelopmental disorders via normalization of gene expression.
Persistent epigenetic dysregulation may underlie the pathophysiology of neurodevelopmental disorders, such as autism spec
Persistent epigenetic dysregulation may underlie the pathophysiology of neurodevelopmental disorders, such as autism spec
Autor:
Mitsuhiro Ito, Genay Pilarowski, John Dunlop, Li Zhang, Yasushi Hattori, Rina Baba, Hans T. Bjornsson, Haruhide Kimura, Masaki Daini, Atsushi Nakatani, Satoru Matsuda, Matsumoto Shigemitsu, Emilio Merlo Pich
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 779-791 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 779-791 (2021)
Kabuki syndrome (KS) is a rare cause of intellectual disability primarily caused by loss-of-function mutations in lysine-specific methyltransferase 2D (KMT2D), which normally adds methyl marks to lysine 4 on histone 3. Previous studies have shown tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2adbc4df2183c0c5d1a5a586542ec76a
https://doi.org/10.1101/2020.03.11.986976
https://doi.org/10.1101/2020.03.11.986976
Publikováno v:
Molecular Neurobiology. 54:4243-4256
Neurodegeneration in the adult mammalian central nervous system (CNS) is fundamentally accelerated by its intrinsic neuronal mechanisms, including its poor regenerative capacity and potent extrinsic inhibitory factors. Thus, the treatment of neurodeg