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MC3R links nutritional state to childhood growth and the timing of puberty

Autor: Lam, BYH, Williamson, A, Finer, S, Day, FR, Tadross, JA, Gonçalves Soares, A, Wade, K, Sweeney, P, Bedenbaugh, MN, Porter, DT, Melvin, A, Ellacott, KLJ, Lippert, RN, Buller, S, Rosmaninho-Salgado, J, Dowsett, GKC, Ridley, KE, Xu, Z, Cimino, I, Rimmington, D, Rainbow, K, Duckett, K, Holmqvist, S, Khan, A, Dai, X, Bochukova, EG, Genes & Health Research Team, Trembath, RC, Martin, HC, Coll, AP, Rowitch, DH, Wareham, NJ, Van Heel, DA, Timpson, N, Simerly, RB, Ong, KK, Cone, RD, Langenberg, C, Perry, JRB, Yeo, GS, O'Rahilly, S

The state of somatic energy stores in metazoans is communicated to the brain, which regulates key aspects of behaviour, growth, nutrient partitioning and development1. The central melanocortin system acts through melanocortin 4 receptor (MC4R) to con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fea96e53d6ebf5fbc07720240571134

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

Autor: Patel, S., Alvarez-Guaita, A., Melvin, A., Rimmington, D., Dattilo, A., Miedzybrodzka, E. L., Cimino, I., Maurin, Anne-Catherine, Roberts, G. P., Meek, C. L., Virtue, S., Sparks, L. M., Parsons, S. A., Redman, L. M., Bray, G. A., Liou, A. P., Woods, R. M., Parry, S. A., Jeppesen, P. B., Kolnes, A. J., Harding, H. P., Ron, D., Vidal-Puig, A., Reimann, F., Gribble, F. M., Hulston, C. J., Farooqi, I. S., Fafournoux, Pierre, Smith, S. R., Jensen, J., Breen, D., Wu, Z., Zhang, B. B., Coll, A. P., Savage, D. B., O'Rahilly, S.

Publikováno v: Cell Metabolism
Cell Metabolism, 2019, 29 (3), pp.707-718.e8. ⟨10.1016/j.cmet.2018.12.016⟩
Patel, S, Alvarez-Guaita, A, Melvin, A, Rimmington, D, Dattilo, A, Miedzybrodzka, E L, Cimino, I, Maurin, A C, Roberts, G P, Meek, C L, Virtue, S, Sparks, L M, Parsons, S A, Redman, L M, Bray, G A, Liou, A P, Woods, R M, Parry, S A, Jeppesen, P B, Kolnes, A J, Harding, H P, Ron, D, Vidal-Puig, A, Reimann, F, Gribble, F M, Hulston, C J, Farooqi, I S, Fafournoux, P, Smith, S R, Jensen, J, Breen, D, Wu, Z, Zhang, B B, Coll, A P, Savage, D B & O'Rahilly, S 2019, ' GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans ', Cell Metabolism, vol. 29, no. 3, pp. 707-718.e8 . https://doi.org/10.1016/j.cmet.2018.12.016
Cell Metabolism, Elsevier, 2019, Epub ahead of print, ⟨10.1016/j.cmet.2018.12.016⟩
Cell Metabolism, Elsevier, 2019, 29 (3), pp.707-718.e8. ⟨10.1016/j.cmet.2018.12.016⟩
Cell Metabolism, 2019, Epub ahead of print (3), ⟨10.1016/j.cmet.2018.12.016⟩
Cell Metabolism, Elsevier, 2019, Epub ahead of print (3), ⟨10.1016/j.cmet.2018.12.016⟩

Summary GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity suggest that GDF15 may play a physiological role in energy bala

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597eddd3d02767a85945b3887b888c98
https://hal.inrae.fr/hal-02952242

Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty

Autor: Howard SR, Guasti L, Poliandri A, David A, Cabrera CP, Barnes MR, Wehkalampi K, O'Rahilly S, Aiken CE, Coll AP, Ma M, Rimmington D, Yeo GSH, Dunkel L

Context: Self-limited delayed puberty (DP) is often associated with a delay in physical maturation, but although highly heritable the causal genetic factors remain elusive. Genome-wide association studies of the timing of puberty have identified mult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a77562f30b8cb462c63cfb8a89ff840
http://hdl.handle.net/10138/234208