Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Rimas V, Lukas"'
Autor:
Víctor A. Arrieta, Andrew Gould, Kwang-Soo Kim, Karl J. Habashy, Crismita Dmello, Gustavo I. Vázquez-Cervantes, Irina Palacín-Aliana, Graysen McManus, Christina Amidei, Cristal Gomez, Silpol Dhiantravan, Li Chen, Daniel Y. Zhang, Ruth Saganty, Meghan E. Cholak, Surya Pandey, Matthew McCord, Kathleen McCortney, Brandyn Castro, Rachel Ward, Miguel Muzzio, Guillaume Bouchoux, Carole Desseaux, Michael Canney, Alexandre Carpentier, Bin Zhang, Jason M. Miska, Maciej S. Lesniak, Craig M. Horbinski, Rimas V. Lukas, Roger Stupp, Catalina Lee-Chang, Adam M. Sonabend
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Given the marginal penetration of most drugs across the blood-brain barrier, the efficacy of various agents remains limited for glioblastoma (GBM). Here we employ low-intensity pulsed ultrasound (LIPU) and intravenously administered microbub
Externí odkaz:
https://doaj.org/article/79679c002d644430b29884550815aa26
Autor:
Priya Kumthekar, Madison Lyleroehr, Leilani Lacson, Rimas V. Lukas, Karan Dixit, Roger Stupp, Timothy Kruser, Jeff Raizer, Alexander Hou, Sean Sachdev, Margaret Schwartz, Jessica Bajas PA, Ray Lezon, Karyn Schmidt, Christina Amidei, Karen Kaiser
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Tumor Treating Fields (TTFields) Therapy is an FDA-approved therapy in the first line and recurrent setting for glioblastoma. Despite Phase 3 evidence showing improved survival with TTFields, it is not uniformly utilized. We aimed
Externí odkaz:
https://doaj.org/article/d7895edb0e734564b205c572113db00c
Autor:
Erik E. Rabin, Jonathan Huang, Miri Kim, Andreas Mozny, Kristen L. Lauing, Manon Penco-Campillo, Lijie Zhai, Prashant Bommi, Xinlei Mi, Erica A. Power, Vikram C. Prabhu, Douglas E. Anderson, Kevin P. Barton, Theresa L. Walunas, Gary E. Schiltz, Christina Amidei, Pilar Sanchez-Gomez, Jigisha P. Thakkar, Rimas V. Lukas, Derek A. Wainwright
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 38, Iss , Pp 100753- (2024)
Background: Increased age is a strong and unfavorable prognostic factor for patients with glioblastoma (GBM). However, the relationships between stratified patient age, comorbidities, and medications have yet to be explored in GBM patient survival an
Externí odkaz:
https://doaj.org/article/841cdbd3c0e44477be3cf471311e57cb
Autor:
Matthew McCord, Pouya Jamshidi, Vineeth Thirunavu, Lucas Santana-Santos, Erica Vormittag-Nocito, David Dittman, Stephanie Parker, Joseph Baczkowski, Lawrence Jennings, Jordain Walshon, Kathleen McCortney, Kristyn Galbraith, Hui Zhang, Rimas V. Lukas, Roger Stupp, Karan Dixit, Priya Kumthekar, Amy B. Heimberger, Matija Snuderl, Craig Horbinski
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract MGMT promoter methylation testing is required for prognosis and predicting temozolomide response in gliomas. Accurate results depend on sufficient tumor cellularity, but histologic estimates of cellularity are subjective. We sought to determ
Externí odkaz:
https://doaj.org/article/c76fde180aa142ce9de66226ad2f660b
Autor:
Ruochen Du, Shashwat Tripathi, Hinda Najem, Daniel J. Brat, Rimas V. Lukas, Peng Zhang, Amy B. Heimberger
Publikováno v:
Cells, Vol 13, Iss 10, p 823 (2024)
Macrophages and microglia are professional phagocytes that sense and migrate toward “eat-me” signals. The role of phagocytic cells is to maintain homeostasis by engulfing senescent or apoptotic cells, debris, and abnormally aggregated macromolecu
Externí odkaz:
https://doaj.org/article/6bc6d5a7ca8d412085c42601a729f555
Autor:
Scott A Wu, Dan Tong Jia, Margaret Schwartz, Mary Mulcahy, Kuanghua Guo, Matthew C Tate, Sean Sachdev, Nicolas Kostelecky, David J Escobar, Daniel J Brat, Amy B Heimberger, Rimas V Lukas
Publikováno v:
CNS Oncology, Vol 12, Iss 3 (2023)
Materials & methods: We recently reported the largest trial of breast cancer patients with HER2 positive leptomeningeal metastases (LM) treated with trastuzumab. An additional treatment indication was explored as part of a single institution retrospe
Externí odkaz:
https://doaj.org/article/71908c412a07460c9e77e4e1c8dc9f98
Autor:
Michael R. Drumm, Wenxia Wang, Thomas K. Sears, Kirsten Bell-Burdett, Rodrigo Javier, Kristen Y. Cotton, Brynna Webb, Kayla Byrne, Dusten Unruh, Vineeth Thirunavu, Jordain Walshon, Alicia Steffens, Kathleen McCortney, Rimas V. Lukas, Joanna J. Phillips, Esraa Mohamed, John D. Finan, Lucas Santana-Santos, Amy B. Heimberger, Colin K. Franz, Jonathan Kurz, Jessica W. Templer, Geoffrey T. Swanson, Craig Horbinski
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Seizures are a frequent complication of adult-type diffuse gliomas, and are often difficult to control with medications. Gliomas with mutations in isocitrate dehydrogenase 1 or 2 (IDHmut) are more likely than IDH–wild type (IDHwt) gliomas to cause
Externí odkaz:
https://doaj.org/article/7fc24269c7a640d7a68744806d41d5ca
Autor:
Amy B. Heimberger, Rimas V. Lukas
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Tryptophan (Trp) metabolism plays a central role in sleep, mood, and immune system regulation. The kynurenine pathway (KP), which is regulated by the enzymes tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3 dioxygenase (IDO), which catalyze the c
Externí odkaz:
https://doaj.org/article/f0556548f34b4b788adf09cc3d54c8b4
Autor:
Siqing Fu, David E. Piccioni, Hongtao Liu, Rimas V. Lukas, Santosh Kesari, Dawit Aregawi, David S. Hong, Kenichiro Yamaguchi, Kate Whicher, Yi Zhang, Yu-Luan Chen, Nagaraju Poola, John Eddy, David Blum
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract WT2725 is a Wilms’ tumor gene 1 (WT1)-derived-oligopeptide vaccine designed to induce WT1-specific cytotoxic T-lymphocytes against WT1+ tumors in human leukocyte antigen (HLA)-A*0201+ and/or HLA-A*0206+ patients. Here, we report the result
Externí odkaz:
https://doaj.org/article/60746137df784b578782dc3342f39baf
A systematic review of pharmacologic treatment efficacy for depression in older patients with cancer
Autor:
Erik E. Rabin, Miri Kim, Andreas Mozny, Krislyn Cardoza, April C. Bell, Lijie Zhai, Prashant Bommi, Kristen L. Lauing, Amanda L. King, Terri S. Armstrong, Theresa L. Walunas, Deyu Fang, Ishan Roy, John D. Peipert, Erica Sieg, Xinlei Mi, Christina Amidei, Rimas V. Lukas, Derek A. Wainwright
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 21, Iss , Pp 100449- (2022)
Background: Older adults ≥65 years of age represent the majority of new cancer diagnoses and are vulnerable to developing depression-like symptoms. Evaluation and management of depression in older cancer patients is underappreciated despite its hig
Externí odkaz:
https://doaj.org/article/6aef1043ea3d42ef90b36fa9a0d1bda6