Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Rimas Orentas"'
Autor:
Michael Maschan, Paolo F. Caimi, Jane Reese-Koc, Gabriela Pacheco Sanchez, Ashish A. Sharma, Olga Molostova, Larisa Shelikhova, Dmitriy Pershin, Alexey Stepanov, Yakov Muzalevskii, Vinicius G. Suzart, Folashade Otegbeye, David Wald, Ying Xiong, Darong Wu, Adam Knight, Ibe Oparaocha, Beatrix Ferencz, Andre Roy, Andrew Worden, Winfried Kruger, Michael Kadan, Dina Schneider, Rimas Orentas, Rafick-Pierre Sekaly, Marcos de Lima, Boro Dropulić
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Strategies to address the challenges associated with product manufacturing can improve chimeric antigen receptor (CAR) cell–based therapeutics. Here the authors report the results of two clinical trials in patients with B-cell malignancies, showing
Externí odkaz:
https://doaj.org/article/1879f85252424882a5288bc97bee3406
Autor:
Kim Anthony-Gonda, Alex Ray, Hang Su, Yuge Wang, Ying Xiong, Danica Lee, Ariele Block, Vanessa Chilunda, Jessica Weiselberg, Lily Zemelko, Yen Y. Wang, Sarah Kleinsorge-Block, Jane S. Reese, Marcos de Lima, Christina Ochsenbauer, John C. Kappes, Dimiter S. Dimitrov, Rimas Orentas, Steven G. Deeks, Rachel L. Rutishauser, Joan W. Berman, Harris Goldstein, Boro Dropulić
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
HIV-specific chimeric antigen receptor–T cell (CAR T cell) therapies are candidates to functionally cure HIV infection in people with HIV (PWH) by eliminating reactivated HIV-infected cells derived from latently infected cells within the HIV reserv
Externí odkaz:
https://doaj.org/article/07c21215b58f4bf69b7d186bb38fd62e
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Phage display is a well-established technology for in vitro selection of monoclonal antibodies (mAb), and more than 12 antibodies isolated from phage displayed libraries of different formats have been approved for therapy. We have constructed a large
Externí odkaz:
https://doaj.org/article/5403251b0c754604a2bcf9ddbf98c8ed
Autor:
Hamenth Kumar Palani, Arun Kumar Arunachalam, Mohammed Yasar, Arvind Venkatraman, Uday Kulkarni, Sharon Anbumalar Lionel, Sushil Selvarajan, Anu Korula, Aby Abraham, Biju George, Jennifer E. Adair, Rimas Orentas, Boro Dropulic, Vikram Mathews
Publikováno v:
Bone Marrow Transplantation. 58:160-167
Chimeric Antigen Receptor (CAR) T cell therapy is an accepted standard of care for relapsed/refractory B cell malignancies. However, the high cost of existing industry-driven centralized production makes this therapy unaffordable in low and middle-in
Autor:
Zachary Jackson, Anne Roe, Ashish Arunkumar Sharma, Filipa Blasco Tavares Pereira Lopes, Aarthi Talla, Sarah Kleinsorge-Block, Kayla Zamborsky, Jennifer Schiavone, Shivaprasad Manjappa, Robert Schauner, Grace Lee, Ruifu Liu, Paolo F. Caimi, Ying Xiong, Winfried Krueger, Andrew Worden, Mike Kadan, Dina Schneider, Rimas Orentas, Boro Dropulic, Rafick-Pierre Sekaly, Marcos de Lima, David N. Wald, Jane S. Reese
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Chimeric antigen receptor T cells (CAR-T cell) targeting CD19 are effective against several subtypes of CD19-expressing hematologic malignancies. Centralized manufacturing has allowed rapid expansion of this cellular therapy, but it may be associated
Externí odkaz:
https://doaj.org/article/8d0bad17627d4c10b8f6a1d433064624
Autor:
Rafijul Bari, Markus Granzin, Kam Sze Tsang, Andre Roy, Winfried Krueger, Rimas Orentas, Dina Schneider, Rita Pfeifer, Nina Moeker, Els Verhoeyen, Boro Dropulic, Wing Leung
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/5ae3cd23182948279b88b3a82053139a
Autor:
Rafijul Bari, Markus Granzin, Kam Sze Tsang, Andre Roy, Winfried Krueger, Rimas Orentas, Dina Schneider, Rita Pfeifer, Nina Moeker, Els Verhoeyen, Boro Dropulic, Wing Leung
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Genetic engineering is an important tool for redirecting the function of various types of immune cells and their use for therapeutic purpose. Although NK cells have many beneficial therapeutic features, genetic engineering of immune cells for targete
Externí odkaz:
https://doaj.org/article/a6dabf4a1a604068862ebeff7b4bb4a1
Autor:
Jennifer E Adair, Kim Anthony-Gonda, Lois Bayigga, Rimas Orentas, Cissy Kityo Mutuluuza, Vikram Mathews, Boro Dropulić
Publikováno v:
The Lancet. Haematology. 9(11)
Autor:
Hai-Feng Zhang, Wei Li, Christopher Hughes, Rajesh Kumar, Alberto Delaidelli, Yue Zhou Huang, Michael Lizardo, Rimas Orentas, Dimiter Dimitrov, Poul Sorensen
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Samuel A. Ritmeester-Loy, Jonathan D Lautz, Yue Zhang-Wong, Joshua Gustafson, Ashley Wilson, Chenwei Lin, Philip R. Gafken, Michael C Jensen, Rimas Orentas, Stephen E.P. Smith
Cells rely on activity-dependent protein-protein interactions to convey biological signals, but the state-dependent interactome is notoriously cell-specific and undercharacterized1. In the case of chimeric antigen receptor (CAR) T cells containing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::978b188437d9d443b4af34aa5116201b
https://doi.org/10.1101/2022.06.07.495180
https://doi.org/10.1101/2022.06.07.495180