Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rima Kandil"'
Autor:
Rima Kandil, Domizia Baldassi, Sebastian Böhlen, Joschka T. Müller, David C. Jürgens, Tonia Bargmann, Susann Dehmel, Yuran Xie, Aditi Mehta, Katherina Sewald, Olivia M. Merkel
GATA3 gene silencing in activated T cells displays a promising option to early-on undermine pathological pathways in the disease formation of allergic asthma. The central transcription factor of T helper 2 (Th2) cell cytokines IL-4, IL-5, and IL-13 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68da4d25421e2c7c46cec7acbb0f1e18
https://publica.fraunhofer.de/handle/publica/439564
https://publica.fraunhofer.de/handle/publica/439564
Autor:
Olivia M. Merkel, Rima Kandil
Publikováno v:
Current Opinion in Colloid & Interface Science
With its nearly unrestricted possibilities, gene therapy attracts more and more significance in modern-day research. The only issue still seeming to hold back its clinical success is the actual effective delivery of genetic material. Nucleic acids ar
Autor:
Olivia M. Merkel, Hartmann Harz, Rima Kandil, Anna Moszczynska, Suzie H. Pun, Yilong Cheng, Akhil Sharma, Yuran Xie, Daniel P. Feldmann, Heinrich Leonhardt, David J. Peeler, Mariam Mohammadi
Publikováno v:
Journal of Controlled Release
The block copolymer VIPER (virus-inspired polymer for endosomal release) has been reported to be a promising novel delivery system of DNA plasmids both in vitro and in vivo . VIPER is comprised of a polycation segment for condensation of nucleic acid
Autor:
Tomoko Fujiwara, Yuran Xie, Daniel G. Abebe, Ying Li, Teresa Kraus, Rima Kandil, Nardhy Gomez-Lopez, Olivia M. Merkel, Mariam Mohammadi
Publikováno v:
Journal of Controlled Release. 244:269-279
New folic acid (FA) coupled three layered micelles (3LM) were designed to encapsulate DNA, and their application as delivery system that specifically targets activated macrophages was investigated for new treatment options in rheumatoid arthritis (RA
Autor:
Aditi Mehta, Yuran Xie, Rima Kandil, Ralf Heermann, Lorenz Isert, Kirsten Jung, Olivia M. Merkel
Publikováno v:
Advanced Therapeutics
RNA interference (RNAi) offers the potential to selectively silence disease-related genes in defined cell subsets. Translation into the clinical routine is, however, still hampered by the lack of efficient carrier systems for therapeutic siRNA, endos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1283626deb55bdda73e072dc35b9131
https://europepmc.org/articles/PMC6675603/
https://europepmc.org/articles/PMC6675603/
Autor:
Olivia M. Merkel, Rima Kandil
Publikováno v:
Therapeutic Delivery
Graphical abstract [Formula: see text]
Publikováno v:
Macromolecular Bioscience. 15:698-711
"Three-layered micelles" (3LM) composed of two triblock copolymers, poly(L-lactide)-b-polyethyleneimine-b-poly(L-lactide) (PLLA-PEI-PLLA) and poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) (PLLA-PEG-PLLA) are designed to combine electrosta
Autor:
Rima Kandil, Olivia M. Merkel, Aditi Mehta, Ralf Heermann, Lorenz Isert, Yuran Xie, Kirsten Jung
Publikováno v:
Advanced Therapeutics. 2:1970015
Autor:
Daniel G, Abebe, Rima, Kandil, Teresa, Kraus, Maha, Elsayed, Tomoko, Fujiwara, Olivia M, Merkel
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1445
Polymeric micelles have found a growing interest as gene vectors due to the serious safety concerns associated with viral vectors. In particular, the cationic polymer polyethylene imine (PEI) has shown relatively high condensation and transfection ef