Nanotoxicologic Effects of PLGA Nanoparticles Formulated with a Cell-Penetrating Peptide: Searching for a Safe pDNA Delivery System for the Lungs

Autor: Larissa Gomes dos Reis, Wing-Hin Lee, Maree Svolos, Lyn Margaret Moir, Rima Jaber, Norbert Windhab, Paul Michael Young, Daniela Traini

Publikováno v: Pharmaceutics, Vol 11, Iss 1, p 12 (2019)

The use of cell-penetrating peptides (CPPs) in combination with nanoparticles (NPs) shows great potential for intracellular delivery of DNA. Currently, its application is limited due to the potential toxicity and unknown long-term side effects. In th

Externí odkaz: https://doaj.org/article/f4af0c2fd0204cd3a9243111e25c87a8

A comparative assessment of continuous production techniques to generate sub-micron size PLGA particles

Autor: Eric A. W. van Dinther, Carl G. Figdor, Oya Tagit, Rima Jaber, Maria Camilla Operti, David Fecher, Silko Grimm

Publikováno v: International Journal of Pharmaceutics, 550, 1-2, pp. 140-148
International Journal of Pharmaceutics
International Journal of Pharmaceutics, 550, 140-148

The clinical and commercial development of polymeric sub-micron size formulations based on poly(lactic-co-glycolic acid) (PLGA) particles is hampered by the challenges related to their good manufacturing practice (GMP)-compliant, scale-up production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c817c7d9359d913a5f62a5ffe6d2e415
https://doi.org/10.1016/j.ijpharm.2018.08.044

Delivery of pDNA Polyplexes to Bronchial and Alveolar Epithelial Cells Using a Mesh Nebulizer

Autor: Maree Svolos, Larissa Gomes dos Reis, Lyn M. Moir, Paul M. Young, Norbert Windhab, Rima Jaber, Daniela Traini

Publikováno v: Pharmaceutical Research. 36

In this study, a cell penetrating peptide was used as an uptake enhancer for pDNA delivery to the lungs. Polyplexes were prepared between pDNA and CPP. Intracellular delivery of pDNA was assessed in both alveolar (A549) and bronchial (Calu-3) epithel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2642fc849ef46b18a937500656e18e
https://doi.org/10.1007/s11095-018-2542-y