Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization[S]

Autor: Lily C. Chao, Kevin Wroblewski, Olga R. Ilkayeva, Robert D. Stevens, James Bain, Gretchen A. Meyer, Simon Schenk, Leonel Martinez, Laurent Vergnes, Vihang A. Narkar, Brian G. Drew, Cynthia Hong, Rima Boyadjian, Andrea L. Hevener, Ronald M. Evans, Karen Reue, Melissa J. Spencer, Christopher B. Newgard, Peter Tontonoz

Publikováno v: Journal of Lipid Research, Vol 53, Iss 12, Pp 2610-2619 (2012)

Mitochondrial dysfunction has been implicated in the pathogenesis of type 2 diabetes. Identifying novel regulators of mitochondrial bioenergetics will broaden our understanding of regulatory checkpoints that coordinate complex metabolic pathways. We

Externí odkaz: https://doaj.org/article/200f6c56942e45de9e72f398c1dfc174

Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target

Autor: Cynthia Hong, Robert Walczak, Helena Dhamko, Michelle N. Bradley, Chaitra Marathe, Rima Boyadjian, Jon V. Salazar, Peter Tontonoz

Publikováno v: Journal of Lipid Research, Vol 52, Iss 3, Pp 531-539 (2011)

Ligand activation of liver X receptors (LXRs) has been shown to impact both lipid metabolism and inflammation. One complicating factor in studies utilizing synthetic LXR agonists is the potential for pharmacologic and receptor-independent effects. He

Externí odkaz: https://doaj.org/article/4cf9666bee714852a9bce1f5a9efa4f0

LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice[S]

Autor: Alan M. Fogelman, Cynthia Hong, Srinivasa T. Reddy, Victor Grijalva, Alan C. Wagner, Susan Realegeno, Brian J. Van Lenten, Xin Rong, Lawrence W. Castellani, Rima Boyadjian, Peter Tontonoz, Michelle N. Bradley, Jon Salazar, Rajendra K. Tangirala, Xuping Wang, Aldons J. Lusis

Publikováno v: Journal of Lipid Research, Vol 53, Iss 6, Pp 1126-1133 (2012)
Journal of Lipid Research

The liver X receptor (LXR) signaling pathway is an important modulator of atherosclerosis, but the relative importance of the two LXRs in atheroprotection is incompletely understood. We show here that LXRα, the dominant LXR isotype expressed in live

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2413549ce1e2bb1298d8a001524fe52e
http://www.sciencedirect.com/science/article/pii/S0022227520317053

TLE3 Is a Dual-Function Transcriptional Coregulator of Adipogenesis

Autor: Enrique Saez, Andrea L. Hevener, Christian Schmedt, Wen Ling Chou, C. Godio, Lily C. Chao, Kevin Wroblewski, Peter Tontonoz, Ronni Nielsen, Susanne Mandrup, Hironori Waki, Rima Boyadjian, Claudio J. Villanueva, Leo Vargas

Publikováno v: Villanueva, C J, Waki, H, Godio, C, Nielsen, R, Chou, W-L, Vargas, L, Wroblewski, K, Schmedt, C, Chao, L C, Boyadjian, R, Mandrup, S, Hevener, A, Saez, E & Tontonoz, P 2011, ' TLE3 Is a Dual-Function Transcriptional Coregulator of Adipogenesis ', Cell Metabolism, vol. 13, no. 4, pp. 413-27 . https://doi.org/10.1016/j.cmet.2011.02.014

SummaryPPARγ and Wnt signaling are central positive and negative regulators of adipogenesis, respectively. Here we identify the groucho family member TLE3 as a transcriptional integrator of the PPARγ and Wnt pathways. TLE3 is a direct target of PPA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ad383dc9da6af43c857a3472a5a11b
https://doi.org/10.1016/j.cmet.2011.02.014

Physiological insulinemia acutely modulates plasma leptin

Autor: Vikram Kamdar, Sujata Jinagouda, Ragui Michael, Arshad M. Khan, Garry M. Steil, Mohammed F. Saad, Alok Sharma, Rima Boyadjian, Maggy G. Riad-Gabriel

Publikováno v: Diabetes. 47:544-549

Whether insulin acutely regulates plasma leptin in humans is controversial. We examined the dosage-response and time-course characteristics of the effect of insulin on leptin in 10 men (age 42+/-2 years [mean+/-SE]; BMI 29.3+/-2.0 kg/m2). Each indivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bb257da02487ed096b397dc86644d6
https://doi.org/10.2337/diabetes.47.4.544