Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Rima Al-awar"'
Autor:
William D. Gwynne, Mirza S. Shakeel, Adele Girgis-Gabardo, Kwang H. Kim, Emily Ford, Anna Dvorkin-Gheva, Craig Aarts, Methvin Isaac, Rima Al-awar, John A. Hassell
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-17 (2020)
Abstract Background Breast tumor initiating cells (BTIC) are stem-like cells that initiate and sustain tumor growth, and drive disease recurrence. Identifying therapies targeting BTIC has been hindered due primarily to their scarcity in tumors. We pr
Externí odkaz:
https://doaj.org/article/8582578dace944f6837d54e4a3840059
Autor:
Magdalena M. Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L. Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C. dela Seña, Tsukasa Sugo, Kozo Hayashi, David McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Eric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H. Arrowsmith, Masoud Vedadi, Peter J. Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Protein arginine methyltransferases (PRMTs) are increasingly recognized as potential therapeutic targets but PRMT7 remains an understudied member of this enzyme family. Here, the authors develop a chemical probe for PRMT7 and apply it to elucidate th
Externí odkaz:
https://doaj.org/article/03bef969e65b4b6bb250bb2886960e81
Autor:
Samir H. Barghout, Ahmed Aman, Kazem Nouri, Zachary Blatman, Karen Arevalo, Geethu E. Thomas, Neil MacLean, Rose Hurren, Troy Ketela, Mehakpreet Saini, Moustafa Abohawya, Taira Kiyota, Rima Al-Awar, Aaron D. Schimmer
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
TAK-243 is a first-in-class inhibitor of ubiquitin-like modifier activating enzyme 1 that catalyzes ubiquitin activation, the first step in the ubiquitylation cascade. Based on its preclinical efficacy and tolerability, TAK-243 has been advanced to p
Externí odkaz:
https://doaj.org/article/d082e4930596459b8898e21f8ca1f16d
Autor:
Maria I. Edilova, Jaclyn C. Law, Safoura Zangiabadi, Kenneth Ting, Achire N. Mbanwi, Andrea Arruda, David Uehling, Methvin Isaac, Michael Prakesch, Rima Al-awar, Mark D. Minden, Ali A. Abdul-Sater, Tania H. Watts
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
TRAF1 is a pro-survival adaptor molecule in TNFR superfamily (TNFRSF) signaling. TRAF1 is overexpressed in many B cell cancers including refractory chronic lymphocytic leukemia (CLL). Little has been done to assess the role of TRAF1 in human cancer.
Externí odkaz:
https://doaj.org/article/b522459ea1914c9fb7a753c1f3981273
Autor:
Mauricio Medrano, Laudine Communal, Kevin R. Brown, Marcin Iwanicki, Josee Normand, Joshua Paterson, Fabrice Sircoulomb, Paul Krzyzanowski, Marian Novak, Sasha A. Doodnauth, Fernando Suarez Saiz, Jane Cullis, Rima Al-awar, Benjamin G. Neel, John McPherson, Ronny Drapkin, Laurie Ailles, Anne-Marie Mes-Massons, Robert Rottapel
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2343-2358 (2017)
The degree of genetic aberrations characteristic of high-grade serous ovarian cancer (HGSC) makes identification of the molecular features that drive tumor progression difficult. Here, we perform genome-wide RNAi screens and comprehensive expression
Externí odkaz:
https://doaj.org/article/5c7651cc95f944028100473e51fbc84b
Autor:
Lamis Hammoud, Jessica R. Adams, Amanda J. Loch, Richard C. Marcellus, David E. Uehling, Ahmed Aman, Christopher Fladd, Trevor D. McKee, Christine E.B. Jo, Rima Al-Awar, Sean E. Egan, Janet Rossant
Publikováno v:
Stem Cell Reports, Vol 7, Iss 4, Pp 787-801 (2016)
Blood vessels are formed through vasculogenesis, followed by remodeling of the endothelial network through angiogenesis. Many events that occur during embryonic vascular development are recapitulated during adult neoangiogenesis, which is critical to
Externí odkaz:
https://doaj.org/article/f367a2280ad24a8bb8a37991fcb032fa
Autor:
Magdalena M. Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L. Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C. dela Seña, Tsukasa Sugo, Kozo Hayashi, David McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Eric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H. Arrowsmith, Masoud Vedadi, Peter J. Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/1528be5dba214e53abc1707b3bc5de39
Autor:
Jeff C Liu, Veronique Voisin, Sharon Wang, Dong‐Yu Wang, Robert A Jones, Alessandro Datti, David Uehling, Rima Al‐awar, Sean E Egan, Gary D Bader, Ming Tsao, Tak W Mak, Eldad Zacksenhaus
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 12, Pp 1542-1560 (2014)
Abstract The tumor suppressors Pten and p53 are frequently lost in breast cancer, yet the consequences of their combined inactivation are poorly understood. Here, we show that mammary‐specific deletion of Pten via WAP‐Cre, which targets alveolar
Externí odkaz:
https://doaj.org/article/1740747192ac46058246e34663ff888d
Autor:
Lianne E. Rotin, Neil MacLean, Ahmed Aman, Marcela Gronda, Feng-Hsu Lin, Rose Hurren, XiaoMing Wang, Jeffrey L Wrana, Alessandro Datti, Rima Al-awar, Mark D. Minden, Aaron D. Schimmer
Publikováno v:
Haematologica, Vol 101, Iss 11 (2016)
Externí odkaz:
https://doaj.org/article/5cfc0304e17b4b0d81b8ba9f953e109a
Autor:
Alice Shi Ming Li, Serah Kimani, Brian Wilson, Mahmoud Noureldin, Héctor González-Álvarez, Ahmed Mamai, Laurent Hoffer, John P. Guilinger, Ying Zhang, Moritz von Rechenberg, Jeremy S. Disch, Christopher J. Mulhern, Belinda L. Slakman, John W. Cuozzo, Aiping Dong, Gennady Poda, Mohammed Mohammed, Punit Saraon, Manish Mittal, Pratik Modh, Vaibhavi Rathod, Bhashant Patel, Suzanne Ackloo, Vijayaratnam Santhakumar, Magdalena M Szewczyk, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Richard Marcellus, Marie-Aude Guié, Anthony D. Keefe, Peter J. Brown, Levon Halabelian, Rima Al-awar, Masoud Vedadi
Publikováno v:
Journal of Medicinal Chemistry. 66:5041-5060