Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Rima, Mustafa"'
Autor:
Rima Mustafa, Michelle M. J. Mens, Arno van Hilten, Jian Huang, Gennady Roshchupkin, Tianxiao Huan, Linda Broer, Joyce B. J. van Meurs, Paul Elliott, Daniel Levy, M. Arfan Ikram, Marina Evangelou, Abbas Dehghan, Mohsen Ghanbari
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-26 (2024)
Abstract Background MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Perturbations in plasma miRNA levels are known to impact disease risk and have potential as disease biomarkers. Exploring the genet
Externí odkaz:
https://doaj.org/article/625b253401c940869bcf67b3973bd481
Autor:
Tianxiao Huan, Roby Joehanes, Jian Rong, Ming-Huei Chen, Rima Mustafa, Abbas Dehghan, Mohsen Ghanbari, Hannah Karlin, Shih-Jen Hwang, Paul Courchesne, Martin G. Larson, Andrew D. Johnson, Jane E. Freedman, Daniel Levy
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110988- (2024)
Summary: MicroRNAs, crucial in regulating protein-coding gene expression, are implicated in various diseases. We performed a genome-wide association study of plasma miRNAs (ex-miRNAs) in 3,743 Framingham Heart Study (FHS) participants and identified
Externí odkaz:
https://doaj.org/article/0af562d70c8345678e66f7cd70367565
Autor:
Felix O’Farrell, Benjamin Aleyakpo, Rima Mustafa, Xiyun Jiang, Rui Climaco Pinto, Paul Elliott, Ioanna Tzoulaki, Abbas Dehghan, Samantha H. Y. Loh, Jeff W. Barclay, L. Miguel Martins, Raha Pazoki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Biological pathways between alcohol consumption and alcohol liver disease (ALD) are not fully understood. We selected genes with known effect on (1) alcohol consumption, (2) liver function, and (3) gene expression. Expression of the ortholog
Externí odkaz:
https://doaj.org/article/0325f1b64d454089b354873fd13c3280
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-13 (2023)
Abstract Background Genetic variants in the coding region could directly affect the structure and expression levels of genes and proteins. However, the importance of variants in the non-coding region, such as microRNAs (miRNAs), remain to be elucidat
Externí odkaz:
https://doaj.org/article/2feaedd7cb314819a5ae8cf846b7dd1a
Autor:
Maedeh Kojouri, Rui Pinto, Rima Mustafa, Jian Huang, He Gao, Paul Elliott, Ioanna Tzoulaki, Abbas Dehghan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The underlying mechanisms linking physical activity to better health are not fully understood. Here we examined the associations between physical activity and small circulatory molecules, the metabolome, to highlight relevant biological path
Externí odkaz:
https://doaj.org/article/65873b2381424c628b8d0148ea952635
Autor:
Matthias Wielscher, Pooja R. Mandaviya, Brigitte Kuehnel, Roby Joehanes, Rima Mustafa, Oliver Robinson, Yan Zhang, Barbara Bodinier, Esther Walton, Pashupati P. Mishra, Pascal Schlosser, Rory Wilson, Pei-Chien Tsai, Saranya Palaniswamy, Riccardo E. Marioni, Giovanni Fiorito, Giovanni Cugliari, Ville Karhunen, Mohsen Ghanbari, Bruce M. Psaty, Marie Loh, Joshua C. Bis, Benjamin Lehne, Nona Sotoodehnia, Ian J. Deary, Marc Chadeau-Hyam, Jennifer A. Brody, Alexia Cardona, Elizabeth Selvin, Alicia K. Smith, Andrew H. Miller, Mylin A. Torres, Eirini Marouli, Xin Gào, Joyce B. J. van Meurs, Johanna Graf-Schindler, Wolfgang Rathmann, Wolfgang Koenig, Annette Peters, Wolfgang Weninger, Matthias Farlik, Tao Zhang, Wei Chen, Yujing Xia, Alexander Teumer, Matthias Nauck, Hans J. Grabe, Macus Doerr, Terho Lehtimäki, Weihua Guan, Lili Milani, Toshiko Tanaka, Krista Fisher, Lindsay L. Waite, Silva Kasela, Paolo Vineis, Niek Verweij, Pim van der Harst, Licia Iacoviello, Carlotta Sacerdote, Salvatore Panico, Vittorio Krogh, Rosario Tumino, Evangelia Tzala, Giuseppe Matullo, Mikko A. Hurme, Olli T. Raitakari, Elena Colicino, Andrea A. Baccarelli, Mika Kähönen, Karl-Heinz Herzig, Shengxu Li, BIOS consortium, Karen N. Conneely, Jaspal S. Kooner, Anna Köttgen, Bastiaan T. Heijmans, Panos Deloukas, Caroline Relton, Ken K. Ong, Jordana T. Bell, Eric Boerwinkle, Paul Elliott, Hermann Brenner, Marian Beekman, Daniel Levy, Melanie Waldenberger, John C. Chambers, Abbas Dehghan, Marjo-Riitta Järvelin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Chronic inflammation, marked by C-reactive protein, has been associated with changes in methylation, but the causal relationship is unclear. Here, the authors perform a Epigenome-wide association meta-analysis for C-reactive protein levels and find t
Externí odkaz:
https://doaj.org/article/715a1a2d6b1f44f19a7bcf745876ed05
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0295004 (2023)
BackgroundThe impact of elevated systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDL-C) on the risk of coronary heart disease (CHD) at different stages of life is unclear. We aimed to investigate whether genetically mediated SB
Externí odkaz:
https://doaj.org/article/741db0f5057741759a2e1219566f82c0
Autor:
Nicolien A. van Vliet, Maxime M. Bos, Carisha S. Thesing, Layal Chaker, Maik Pietzner, Evelyn Houtman, Matt J. Neville, Ruifang Li-Gao, Stella Trompet, Rima Mustafa, Fariba Ahmadizar, Marian Beekman, Mariska Bot, Kathrin Budde, Constantinos Christodoulides, Abbas Dehghan, Christian Delles, Paul Elliott, Marina Evangelou, He Gao, Mohsen Ghanbari, Antonius E. van Herwaarden, M. Arfan Ikram, Martin Jaeger, J. Wouter Jukema, Ibrahim Karaman, Fredrik Karpe, Margreet Kloppenburg, Jennifer M. T. A. Meessen, Ingrid Meulenbelt, Yuri Milaneschi, Simon P. Mooijaart, Dennis O. Mook-Kanamori, Mihai G. Netea, Romana T. Netea-Maier, Robin P. Peeters, Brenda W. J. H. Penninx, Naveed Sattar, P. Eline Slagboom, H. Eka D. Suchiman, Henry Völzke, Ko Willems van Dijk, Raymond Noordam, Diana van Heemst, BBMRI Metabolomics Consortium
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background Observational studies suggest interconnections between thyroid status, metabolism, and risk of coronary artery disease (CAD), but causality remains to be proven. The present study aimed to investigate the potential causal relation
Externí odkaz:
https://doaj.org/article/1f2243259d1f400b993b2f23e8c266e0
Autor:
Maxime M. Bos, Neil J. Goulding, Matthew A. Lee, Amy Hofman, Mariska Bot, René Pool, Lisanne S. Vijfhuizen, Xiang Zhang, Chihua Li, Rima Mustafa, Matt J. Neville, Ruifang Li-Gao, Stella Trompet, Marian Beekman, Nienke R. Biermasz, Dorret I. Boomsma, Irene de Boer, Constantinos Christodoulides, Abbas Dehghan, Ko Willems van Dijk, Ian Ford, Mohsen Ghanbari, Bastiaan T. Heijmans, M. Arfan Ikram, J. Wouter Jukema, Dennis O. Mook-Kanamori, Fredrik Karpe, Annemarie I. Luik, L. H. Lumey, Arn M. J. M. van den Maagdenberg, Simon P. Mooijaart, Renée de Mutsert, Brenda W. J. H. Penninx, Patrick C. N. Rensen, Rebecca C. Richmond, Frits R. Rosendaal, Naveed Sattar, Robert A. Schoevers, P. Eline Slagboom, Gisela M. Terwindt, Carisha S. Thesing, Kaitlin H. Wade, Carolien A. Wijsman, Gonneke Willemsen, Aeilko H. Zwinderman, Diana van Heemst, Raymond Noordam, Deborah A. Lawlor
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background Sleep traits are associated with cardiometabolic disease risk, with evidence from Mendelian randomization (MR) suggesting that insomnia symptoms and shorter sleep duration increase coronary artery disease risk. We combined adjuste
Externí odkaz:
https://doaj.org/article/3a4e89b02a4e4bc9b561d382d0215d2b
Autor:
Íde Cremin, Oliver Watson, Alastair Heffernan, Natsuko Imai, Norin Ahmed, Sandra Bivegete, Teresia Kimani, Demetris Kyriacou, Preveina Mahadevan, Rima Mustafa, Panagiota Pagoni, Marisa Sophiea, Charlie Whittaker, Leo Beacroft, Steven Riley, Matthew C. Fisher
Publikováno v:
Epidemics, Vol 23, Iss , Pp 42-48 (2018)
The study of infectious disease outbreaks is required to train today’s epidemiologists. A typical way to introduce and explain key epidemiological concepts is through the analysis of a historical outbreak. There are, however, few training options t
Externí odkaz:
https://doaj.org/article/597ccf2c239a4bf38af91adff65442b9