Transcriptomic profiling of a multiethnic pediatric NAFLD cohort reveals genes and pathways associated with disease

Autor: Kangning Yao, Elena Tarabra, Daniela Sia, Raffaella Morotti, Rima Fawaz, Pamela Valentino, Nicola Santoro, Sonia Caprio, Silvia Liu, Dean Yimlamai

Publikováno v: Hepatology Communications, Vol 6, Iss 7, Pp 1598-1610 (2022)

Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in children. The mechanisms that drive NAFLD disease progression in this specific patient population remain poorly defined. In this study, we obtained

Externí odkaz: https://doaj.org/article/22e27aec548c4908abc02939d059ee8f

Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study

Autor: Shannon M, Vandriel, Li-Ting, Li, Huiyu, She, Jian-She, Wang, Melissa A, Gilbert, Irena, Jankowska, Piotr, Czubkowski, Dorota, Gliwicz-Miedzińska, Emmanuel M, Gonzales, Emmanuel, Jacquemin, Jérôme, Bouligand, Nancy B, Spinner, Kathleen M, Loomes, David A, Piccoli, Lorenzo, D'Antiga, Emanuele, Nicastro, Étienne, Sokal, Tanguy, Demaret, Noelle H, Ebel, Jeffrey A, Feinstein, Rima, Fawaz, Silvia, Nastasio, Florence, Lacaille, Dominique, Debray, Henrik, Arnell, Björn, Fischler, Susan, Siew, Michael, Stormon, Saul J, Karpen, Rene, Romero, Kyung Mo, Kim, Woo Yim, Baek, Winita, Hardikar, Sahana, Shankar, Amin J, Roberts, Helen M, Evans, M Kyle, Jensen, Marianne, Kavan, Shikha S, Sundaram, Alexander, Chaidez, Palaniswamy, Karthikeyan, Maria Camila, Sanchez, Maria Lorena, Cavalieri, Henkjan J, Verkade, Way Seah, Lee, James E, Squires, Christina, Hajinicolaou, Chatmanee, Lertudomphonwanit, Ryan T, Fischer, Catherine, Larson-Nath, Yael, Mozer-Glassberg, Cigdem, Arikan, Henry C, Lin, Jesus Quintero, Bernabeu, Seema, Alam, Deirdre A, Kelly, Elisa, Carvalho, Cristina Targa, Ferreira, Giuseppe, Indolfi, Ruben E, Quiros-Tejeira, Pinar, Bulut, Pier Luigi, Calvo, Zerrin, Önal, Pamela L, Valentino, Dev M, Desai, John, Eshun, Maria, Rogalidou, Antal, Dezsőfi, Sabina, Wiecek, Gabriella, Nebbia, Raquel Borges, Pinto, Victorien M, Wolters, María Legarda, Tamara, Andréanne N, Zizzo, Jennifer, Garcia, Kathleen, Schwarz, Marisa, Beretta, Thomas Damgaard, Sandahl, Carolina, Jimenez-Rivera, Nanda, Kerkar, Jernej, Brecelj, Quais, Mujawar, Nathalie, Rock, Cristina Molera, Busoms, Wikrom, Karnsakul, Eberhard, Lurz, Ermelinda, Santos-Silva, Niviann, Blondet, Luis, Bujanda, Uzma, Shah, Richard J, Thompson, Bettina E, Hansen, Binita M, Kamath

Publikováno v: Hepatology
Vandriel, S M, Li, L T, She, H, Wang, J S, Gilbert, M A, Jankowska, I, Czubkowski, P, Gliwicz-Miedzińska, D, Gonzales, E M, Jacquemin, E, Bouligand, J, Spinner, N B, Loomes, K M, Piccoli, D A, D'Antiga, L, Nicastro, E, Sokal, É, Demaret, T, Ebel, N H, Feinstein, J A, Fawaz, R, Nastasio, S, Lacaille, F, Debray, D, Arnell, H, Fischler, B, Siew, S, Stormon, M, Karpen, S J, Romero, R, Kim, K M, Baek, W Y, Hardikar, W, Shankar, S, Roberts, A J, Evans, H M, Jensen, M K, Kavan, M, Sundaram, S S, Chaidez, A, Karthikeyan, P, Sanchez, M C, Cavalieri, M L, Verkade, H J, Lee, W S, Squires, J E, Hajinicolaou, C, Lertudomphonwanit, C, Fischer, R T, Sandahl, T D & The Global ALagille Alliance (GALA) Study Group 2023, ' Natural history of liver disease in a large international cohort of children with Alagille syndrome : Results from the GALA study ', Hepatology, vol. 77, no. 2 . https://doi.org/10.1002/hep.32761
Hepatology, Vol. 77, no. 2, p. 512-529 (2023)

Background and aims: Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real-world data are lacking. This study aimed to elucidate the natural history

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa081634c7928ab2481736e90c3d8a8
https://doi.org/10.1002/hep.32761

A quality improvement intervention to decrease the decline in renal function in pediatric liver transplant recipients

Autor: Irini Batsis, Scott Elisofon, Michael Ferguson, Maureen Jonas, Brendan Kimball, Christine Lee, Paul Mitchell, Rima Fawaz

Publikováno v: Pediatric Transplantation. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bd4f0d069734ed4bb27621d0c973b5f
https://doi.org/10.1111/petr.14506

Acute Hepatitis of Unknown Origin in Children: Early Observations from the 2022 Outbreak

Autor: Li-Ya Zhang, Li-Su Huang, Yu-Hang Yue, Rima Fawaz, Joseph K. Lim, Jian-Gao Fan

Publikováno v: Journal of clinical and translational hepatology. 10(3)

Recent reports of acute hepatitis of unknown origin in previously healthy children have been increasing worldwide. The main characteristics of the affected children were jaundice and gastrointestinal symptoms. Their serum aminotransaminase levels wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe58b56f162cd12b664eeda16b5204b
https://pubmed.ncbi.nlm.nih.gov/35836761

Presentation and outcomes of post‐transplant lymphoproliferative disorder at a single institution pediatric transplant center

Autor: Gabriel Ramos‐Gonzalez, Robert Crum, Alec Allain, Timna Agur, Laura O’Melia, Steven Staffa, Sandra K. Burchett, Bradford Siegele, Olga Weinberg, Nancy M. Rodig, Rima Fawaz, Tajinder P Singh, Dawn A. Freiberger, Heung Bae Kim

Publikováno v: Pediatric Transplantation. 26

This study aimed to characterize features present at the time of diagnosis and describe outcomes in patients with post-transplant lymphoproliferative disorder (PTLD) following pediatric solid organ transplantation.We performed a retrospective review

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640d76389203478b278bf871780c0d03
https://doi.org/10.1111/petr.14268