Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rim Malek"'
Autor:
Rim Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J. Bernard, Artur Wnorowski, Helene Martin, José Marco-Contelles, Fakher Chabchoub, Patrick Dallemagne, Christophe Rochais, Krzysztof Jozwiak, Lhassane Ismaili
Publikováno v:
Molecules, Vol 28, Iss 1, p 71 (2022)
Novel multitarget-directed ligands BIGI 4a-d and BIGI 5a-d were designed and synthesized with a simple and cost-efficient procedure via a one-pot three-component Biginelli reaction targeting acetyl-/butyrylcholinesterases inhibition, calcium channel
Externí odkaz:
https://doaj.org/article/c1008cfa0311472f9605360beca986c5
Autor:
Youssef Dgachi, Hélène Martin, Rim Malek, Daniel Jun, Jana Janockova, Vendula Sepsova, Ondrej Soukup, Isabel Iriepa, Ignacio Moraleda, Emna Maalej, M. Carmo Carreiras, Bernard Refouvelet, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 163-170 (2019)
In view of the multifactorial nature of Alzheimer’s disease (AD), multitarget small molecules (MTSM) represent the most potent and attractive therapeutic strategy to design new drugs for Alzheimer’s disease therapy. The new MTSM KojoTacrines (KTs
Externí odkaz:
https://doaj.org/article/e3c0e08c463645d08a8cc7dd58a4bda9
Autor:
Javier Egea, Daniel Diez-Iriepa, Barbara Mordyl, Alejandra Palomino-Antolín, Rim Malek, Lhassane Ismaili, Tereza Kobrlova, Justyna Godyń, Ondrej Soukup, José Marco-Contelles, Agata Siwek, Fakher Chabchoub, Ignacio Moraleda, Cristóbal de los Ríos, Dawid Panek, Céline Demougeot, Perle Totoson, Katarzyna Kieć-Kononowicz, Isabel Iriepa, Monika Głuch-Lutwin, Barbara Malawska, Raquel L Arribas
Publikováno v:
Journal of Medicinal Chemistry. 62:11416-11422
New tritarget small molecules combining Ca2+ channels blockade, cholinesterase, and H3 receptor inhibition were obtained by multicomponent synthesis. Compound 3p has been identified as a very promising lead, showing good Ca2+ channels blockade activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30367824b94baa33e4e87aec58b11b2e
https://doi.org/10.1021/acs.jmedchem.9b00937
https://doi.org/10.1021/acs.jmedchem.9b00937
Autor:
Rim, Malek, Raquel L, Arribas, Alejandra, Palomino-Antolin, Perle, Totoson, Celine, Demougeot, Tereza, Kobrlova, Ondrej, Soukup, Isabel, Iriepa, Ignacio, Moraleda, Daniel, Diez-Iriepa, Justyna, Godyń, Dawid, Panek, Barbara, Malawska, Monika, Głuch-Lutwin, Barbara, Mordyl, Agata, Siwek, Fakher, Chabchoub, José, Marco-Contelles, Katarzyna, Kiec-Kononowicz, Javier, Egea, Cristóbal, de Los Ríos, Lhassane, Ismaili
Publikováno v:
Journal of medicinal chemistry. 62(24)
New tritarget small molecules combining Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cfbef7e688db8aee6b7582e431114316
https://pubmed.ncbi.nlm.nih.gov/31724859
https://pubmed.ncbi.nlm.nih.gov/31724859
Autor:
Krzysztof Jóźwiak, Rim Malek, Artur Wnorowski, Maciej Maj, Ignacio Moraleda, Hélène Martin, Lhassane Ismaili, José Marco-Contelles, Isabel Iriepa, Fakher Chabchoub
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
In this work we describe the synthesis, Ca channel blockade capacity and antioxidant power of N,N-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)-2,6-dimethyl-4-aryl-1,4-dihydropyridine-3,5-dicarboxamides 1–9, a number of multi-target small 1,4-dihydropyridi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40569b33a1ff092b0bf48b9d8ce1186a
https://doi.org/10.1016/j.bioorg.2019.103205
https://doi.org/10.1016/j.bioorg.2019.103205