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New promising generation of phosphates α-aminophosphonates: Design, synthesis, in-vitro biological evaluation and computational study

Autor: Mounia Merabet-Khelassi, Rim Aissa, Régis Guillot, Samia Guezane-Lakoud, Louisa Aribi-Zouioueche, Anna Ignaczak, Marta Adamiak, Lynda Gali, Martial Toffano

A novel category of phosphate-phosphonate compounds is synthesized by a sequence multicomponent reactions strategy of Kabachnik-Fields and Atherton-Todd reactions. All the designed products are obtained with good chemical yields in short reaction tim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8e07f0975efd14754661d46c3b189a
https://hdl.handle.net/11089/43305

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Fiaud’s Acid, a novel organocatalyst for diastereoselective bis α-aminophosphonates synthesis with in-vitro biological evaluation of antifungal, antioxidant and enzymes inhibition potential

Autor: Rim Aissa, Martial Toffano, Samia Guezane-Lakoud, Louisa Aribi-Zouioueche, Lynda Gali

Publikováno v: Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2021, 41, pp.128000. ⟨10.1016/j.bmcl.2021.128000⟩

International audience; Fiaud's acid is used as a novel and effective chiral organocatalyst for bis α-aminophosphonates synthesis with excellent diastereoselectivity and yields within short reaction time. All synthesized bis αaminophosphonates reve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f171da3874608b911f2edf07047b5f7c
https://hal.archives-ouvertes.fr/hal-03304159

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Diastereoselective synthesis of bis(α-aminophosphonates) by lipase catalytic promiscuity

Autor: Louisa Aribi-Zouioueche, Emilie Kolodziej, Samia Guezane-Lakoud, Rim Aissa, Martial Toffano

Publikováno v: New Journal of Chemistry
New Journal of Chemistry, Royal Society of Chemistry, 2019, 43 (21), pp.8153-8159. ⟨10.1039/C8NJ06235H⟩
New Journal of Chemistry, Royal Society of Chemistry, 2019, 43 (21), pp.8153-8159. ⟨10.1039/c8nj06235h⟩

International audience; New bis(α-aminophosphonates) were directly prepared with high diastereoselectivity by lipase catalytic promiscuity in the presence of immobilized Candida antarctica lipase. We focused on the multi-component Kabachnik–Fields

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0d59350040868c801d93665beb04fe
https://doi.org/10.1039/c8nj06235h

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