Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Riley R, Cridge"'
Autor:
Mattia Deluigi, Lena Morstein, Matthias Schuster, Christoph Klenk, Lisa Merklinger, Riley R. Cridge, Lazarus A. de Zhang, Alexander Klipp, Santiago Vacca, Tasneem M. Vaid, Peer R. E. Mittl, Pascal Egloff, Stefanie A. Eberle, Oliver Zerbe, David K. Chalmers, Daniel J. Scott, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
This study reports the X-ray structure of the α1B-adrenergic G protein-coupled receptor bound to an inverse agonist, and unveils key determinants of subtype-selective ligand binding that may help the design of aminergic drugs with fewer side-effects
Externí odkaz:
https://doaj.org/article/9eae3c81d8e34aff9e67ac17ad3df5fe
Autor:
Mattia, Deluigi, Lena, Morstein, Matthias, Schuster, Christoph, Klenk, Lisa, Merklinger, Riley R, Cridge, Lazarus A, de Zhang, Alexander, Klipp, Santiago, Vacca, Tasneem M, Vaid, Peer R E, Mittl, Pascal, Egloff, Stefanie A, Eberle, Oliver, Zerbe, David K, Chalmers, Daniel J, Scott, Andreas, Plückthun
Publikováno v:
Nature Communications
α-adrenergic receptors (αARs) are G protein-coupled receptors that regulate vital functions of the cardiovascular and nervous systems. The therapeutic potential of αARs, however, is largely unexploited and hampered by the scarcity of subtype-selec
Autor:
Berger O; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States., Choi W; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States., Ko CH; NewCures, Innovation and Ventures Office, Northwestern University, Evanston, Illinois 60208, United States., Thompson MP; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States., Avram MJ; Feinberg Medical School, Northwestern University, Chicago, Illinois 60611, United States.; Department of Anesthesiology, Northwestern University, Chicago, Illinois 60611, United States., Scott DJ; The Florey,Parkville, Victoria 3010, Australia.; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, Victoria 3010, Australia., Hoare BL; The Florey,Parkville, Victoria 3010, Australia., Cridge R; The Florey,Parkville, Victoria 3010, Australia., Wheatley M; Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry CV1 5FB, U.K.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands B15 2TT, U.K., Bathgate RAD; The Florey,Parkville, Victoria 3010, Australia.; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, Victoria 3010, Australia., Batlle D; Feinberg Medical School, Northwestern University, Chicago, Illinois 60611, United States.; Department of Medicine Division of Nephrology and Hypertension, Chicago, Illinois 60611, United States., Gianneschi NC; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.; Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States.; Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, United States.; Department of Pharmacology, Northwestern University, Chicago, Illinois 60611, United States.; International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States.; Simpson-Querrey Institute, Northwestern University, Chicago, Illinois 60611, United States.; Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.
Publikováno v:
ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2024 Apr 30; Vol. 7 (5), pp. 1252-1261. Date of Electronic Publication: 2024 Apr 30 (Print Publication: 2024).