Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Riley Gj"'
Autor:
Phillip Jeffrey, Jeannette M. Watson, Charles R. Ashby, Alexander Baxter Smith, Gregor James Macdonald, Geoffrey Stemp, Chris Johnson, David John SmithKline Beecham Pharmaceut. Nash, Clive Leslie GlaxoSmithKline Branch, Izzy Boyfield, Kevin Michael Harlow Thewlis, Kim Y. Winborn, Charlie Reavill, Riley Gj, Antonio Kuok K.łSmithKline Beecham P Vong, Jim J. Hagan, Michael Stewart Beecham Pharmaceuticals Hadley, Steve Parker, Nigel E. Austin, Derek N. Middlemiss, Martyn Wood
Publikováno v:
Journal of Medicinal Chemistry. 46:4952-4964
At their clinical doses, current antipsychotic agents share the property of both dopamine D(2) and D(3) receptor blockade. However, a major disadvantage of many current medications are the observed extrapyramidal side-effects (EPS), postulated to ari
Autor:
Peter Ham, J V Selkirk, Frank E. Blaney, Susannah Davies, L M Gaster, David Malcolm Duckworth, John M. Hatcher, Derek N. Middlemiss, Gary W. Price, Frank King, P. D. Slade, Jim J. Hagan, Wyman Paul Adrian, Graham Francis Joiner, Claire Roberts, Sarah Margaret Jenkins, Carol Routledge, Keith Raymond Mulholland, Riley Gj, Andrew John Jennings, B. J. Jones
Publikováno v:
Journal of Medicinal Chemistry. 41:1218-1235
5-HT1 receptors are members of the G-protein-coupled receptor superfamily and are negatively linked to adenylyl cyclase activity. The human 5-HT1B and 5-HT1D receptors (previously known as 5-HT1Dbeta and 5-HT1Dalpha, respectively), although encoded b
Autor:
Martyn C. Coldwell, Emma E. Scott, Christopher Norbert Johnson, Izzy Boyfield, R. Stacey, Michael Stewart Beecham Pharmaceuticals Hadley, Riley Gj, Geoffrey Stemp, Kevin M. Thewlis
Publikováno v:
ChemInform. 28
Autor:
C. Reavill, Guy A. Kennett, Thomas P. Blackburn, Steven Mark Bromidge, S. Lightowler, Derek N. Middlemiss, David R. Thomas, T.L. Gager, Martyn D. Wood, Brenda K. Trail, V. Holland, Riley Gj, T. Stean, Ian Thomson Forbes, A. Wilson
Publikováno v:
Neuropharmacology. 41(2)
SB-243213 (5-methyl-1-[[-2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline hydrochloride) is a new, selective 5-hydroxytryptamine (5-HT)2C receptor inverse agonist. SB-243213 has high affinity for the human 5-HT2C receptor (p
Autor:
Stephen E. Clarke, G. E. Jones, Steven Mark Bromidge, David T. Davies, Wyman Paul Adrian, Peter Ham, Sean Lightowler, Derek N. Middlemiss, Saunders Dv, Brenda K. Trail, Holland, Keith Raymond Mulholland, Ian Thomson Forbes, Frank E. Blaney, Riley Gj, Thomas P. Blackburn, David Malcolm Duckworth, Guy A. Kennett, Steven Dabbs, Susannah Davies, L M Gaster, Frank King, Wood
Publikováno v:
Journal of medicinal chemistry. 43(6)
The evolution, synthesis, and biological activity of a novel series of 5-HT(2C) receptor inverse agonists are reported. Biarylcarbamoylindolines have been identified with excellent 5-HT(2C) affinity and selectivity over 5-HT(2A) receptors. In additio
Autor:
Saunders Dv, Steven Dabbs, Derek N. Middlemiss, Collin Ll, Andrew John Jennings, Steven Mark Bromidge, Ian Thomson Forbes, Peter J. Lovell, David Malcolm Duckworth, Frank King, Jim J. Hagan, David R. Thomas, Sh K Rahman, Riley Gj
Publikováno v:
Journal of medicinal chemistry. 43(3)
Autor:
Martyn D. Wood, Neil Upton, A.M. Brown, Derek N. Middlemiss, Thomas P. Blackburn, K.Y. Avenell, F. Bright, Ian Thomson Forbes, Guy A. Kennett, Brenda K. Trail, T. Stean, Riley Gj, V. Holland, Steven Mark Bromidge
Publikováno v:
Neuropharmacology. 36(4-5)
SB 242084 has a high affinity (pKi 9.0) for the cloned human 5-HT2C receptor and 100- and 158-fold selectivity over the closely related cloned human 5-HT2B and 5-HT2A subtypes respectively. SB 242084 had over 100-fold selectivity over a range of othe
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